Navigation Links
Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
Date:10/29/2012

PHILADELPHIA New insight into the aggressive behavior of certain adult B-acute lymphoblastic leukemias has provided researchers with a potential new prognostic biomarker and a promising new therapeutic target.

The research, conducted by Ari Melnick, M.D., associate professor of medicine and director of the Raymond and Beverly Sackler Center for Biomedical and Physical Sciences at Weill Cornell Medical College and a hematologist-oncologist at New York-Presbyterian Hospital/Weill Cornell Medical Center, and colleagues, was published in Cancer Discovery, a journal of the American Association for Cancer Research.

Although B-acute lymphoblastic leukemia is highly curable in children, the disease is usually fatal in adults, and researchers have yet to identify why this is the case. Part of the explanation for the poorer outcomes in adults is the higher frequency of genetic alterations associated with unfavorable prognosis.

In order to better understand why these genetic alterations are associated with poor outcomes, Melnick and colleagues studied 215 diagnostic specimens obtained from adults with B-acute lymphoblastic leukemia who were participating in a large Eastern Cooperative Oncology Group phase III clinical trial.

"We performed an integrative epigenomics study to decode the instructions that determine how these cells behave," Melnick said. "The hope was that this would allow us to identify better survival biomarkers and new therapeutic targets."

In many cancers, genetic alterations work in conjunction with epigenetic changes (changes in the way that DNA is modified and packaged) to promote cancerous behaviors. Looking at the B-acute lymphoblastic leukemia specimens, Melnick and colleagues found that many of the leukemias' bad traits were a result of changes in the epigenetic code. In many cases, the epigenetic changes were directly linked to the proteins generated from the genetic alterations and could be
'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Biomarkers can reveal IBS
2. Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
3. Novel biomarkers reveal evidence of radiation exposure
4. Using biomarkers to identify and treat schizophrenia
5. US Army: Pre-injury cartilage biomarkers associated with subsequent ACL injuries
6. Indoor Tanners Rationalize Risky Behavior, Study Finds
7. Targeted therapeutics for colon cancer to be presented at AACR meeting
8. The Ludwig Institute for Cancer Research announces launch of iTeos Therapeutics SA
9. 5 more pharmaceutical companies join NIH initiative to speed therapeutic discovery
10. FORMA Therapeutics teams with TGen Drug Development
11. Device implanted in brain has therapeutic potential for Huntingtons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... Wellesley, Mass. (PRWEB) July 14, 2014 ... its new report, SYNTHETIC BIOLOGY: GLOBAL MARKETS ... to grow to nearly $11.9 billion in 2018, ... of 34.4%. Enabled products account for the fastest ... and 36.7% CAGR. Synthetic biology-enabled products in the ...
(Date:7/14/2014)... SUNDAY, July 13, 2014 (HealthDay News) -- Along with ... people with Alzheimer,s disease and other types of dementia, ... their quality of life, the researchers said. "These ... variety of benefits for people with dementia and their ... Lerner, of Case Western Reserve University and University Hospitals ...
(Date:7/14/2014)... 14, 2014 (HealthDay News) -- Stress can slow a woman,s ... The study included 58 women, average age 53, who were ... given a meal than included 930 calories and 60 grams ... it took the women to burn off those calories and ... stressful events during the previous 24 hours burned 104 fewer ...
(Date:7/14/2014)... July 14, 2014 Skin ... its Grand Opening on Monday, July 14th, located ... The celebration will last all week through Saturday, ... patients. Everyone is welcomed to attend. The business ... provides physician-administered skincare, anti-aging, weight loss services, and ...
(Date:7/14/2014)... California (PRWEB) July 14, 2014 ... to reach USD 4,285.1 million by 2020 growing ... new study by Grand View Research, Inc. Steady ... biology for bioinformatics R&D programs designed for sequencing ... number of clinical studies in pharmacogenomics and pharmacokinetics ...
Breaking Medicine News(10 mins):Health News:Global Market for Synthetic Biology to Reach Nearly $11.9 Billion by 2018 — Enabled Products Account for the Fastest Growing Segment with 36.7% CAGR 2Health News:Global Market for Synthetic Biology to Reach Nearly $11.9 Billion by 2018 — Enabled Products Account for the Fastest Growing Segment with 36.7% CAGR 3Health News:Cataract Surgery a Plus for Someone With Dementia, Study Says 2Health News:Stress May Leave You Heading to the Cookie Jar 2Health News:The Cosmetic Medic Announces Grand Opening of New Skin M.D., a Physician-Administered Anti-aging, Skincare, and Weight Loss Practice 2Health News:The Cosmetic Medic Announces Grand Opening of New Skin M.D., a Physician-Administered Anti-aging, Skincare, and Weight Loss Practice 3Health News:Global Computational Biology Market by Application (Cellular & Biological Simulation), by Services (In-house, Contract) is Expected to Reach USD 4,285.1 Million by 2020 2Health News:Global Computational Biology Market by Application (Cellular & Biological Simulation), by Services (In-house, Contract) is Expected to Reach USD 4,285.1 Million by 2020 3Health News:Global Computational Biology Market by Application (Cellular & Biological Simulation), by Services (In-house, Contract) is Expected to Reach USD 4,285.1 Million by 2020 4Health News:Global Computational Biology Market by Application (Cellular & Biological Simulation), by Services (In-house, Contract) is Expected to Reach USD 4,285.1 Million by 2020 5Health News:Global Computational Biology Market by Application (Cellular & Biological Simulation), by Services (In-house, Contract) is Expected to Reach USD 4,285.1 Million by 2020 6
... ... Chicago, a chiropractor doctor, has developed new techniques to relieve back pain. People with herniated ... , ... 26, 2009 -- Dr. Paul Ruzila, Chiropractic Doctor of HealthSource of Chicago, announced today that ...
... Mary Hayashi Calls on California ... 3rd Annual "Neuropathy Action Awareness Day" , ... continues his push for national health care reform, more ... in Sacramento today to call on Congress to restore ...
... A U.S. District Court judge issued an injunction ... $2 cut in wages for the state,s 400,000 home care workers. ... California counties that were planning on passing the state cut through ... issued by federal judge Claudia Wilken, was in response to a ...
... Arrest Association said Thursday that pop singer Michael Jackson,s death ... cardiac arrest, which kills nearly 300,000 Americans each year and ... "Sudden cardiac arrest (SCA) is the result of an electrical ... attack. It can strike seemingly healthy individuals without warning, ...
... ... Researchers at the Baltimore Veterans Affairs (VA) Medical ... research using a novel ankle robot ("Anklebot"), invented by researchers at ... Veterans Affairs, with stroke patients at the Baltimore VA Medical ...
... In a 6-5 decision in Richmond Medical Center v. Herring ... on partial birth infanticide -- a law that mirrors the federal ... for Life (AUL) provided litigation support to the state ... law. In addition, AUL Senior Counsel Clarke Forsythe assisted the ...
Cached Medicine News:Health News:HealthSource of Chicago: New Techniques for Back Pain Relief in Chicago 2Health News:HealthSource of Chicago: New Techniques for Back Pain Relief in Chicago 3Health News:HealthSource of Chicago: New Techniques for Back Pain Relief in Chicago 4Health News:Neuropathy Patients, Doctors and Medical Professionals Rally in Sacramento to Demand Access to Lifesaving Medical Treatments 2Health News:Neuropathy Patients, Doctors and Medical Professionals Rally in Sacramento to Demand Access to Lifesaving Medical Treatments 3Health News:Veterans Affairs Researchers Study Benefits of Robot for Ankle Rehabilitation 2Health News:Veterans Affairs Researchers Study Benefits of Robot for Ankle Rehabilitation 3Health News:Veterans Affairs Researchers Study Benefits of Robot for Ankle Rehabilitation 4Health News:Americans United for Life Applauds Fourth Circuit Protecting Women and Children by Upholding Virginia Partial Birth Abortion Statute 2
(Date:7/14/2014)... , July 14, 2014  Celsion Corporation (NASDAQ: ... today that the Company will ring the NASDAQ Stock Market ... New York, NY . ... of the Celsion and EGEN management teams will participate in ... pm ET.  A live webcast will be available at ...
(Date:7/14/2014)... Minn. , July 14, 2014  Today, ATS ... announced that it acquired the assets of MicroTest Labs, ... The acquisition of MTL is the first step in ... chemistry laboratory services platform to support the medical device ... known as Accuratus Lab Services , a name ...
(Date:7/14/2014)... 2014  Diomics, Inc., provider of X-Swab™, a ... United States Patent and Trademark Office has issued ... biologic sample collection materials, devices made from them, ... diagnostics. The primary method of ... of DNA from a number of commercially-available swabs ...
Breaking Medicine Technology:Celsion Corporation to Ring the NASDAQ Stock Market Closing Bell on July 16, 2014 2Celsion Corporation to Ring the NASDAQ Stock Market Closing Bell on July 16, 2014 3ATS Labs, Inc. Announces the Acquisition of MicroTest Labs, Inc. 2ATS Labs, Inc. Announces the Acquisition of MicroTest Labs, Inc. 3Diomics Announces Issuance Of U.S. Patents For Novel Biologic Sample DNA Collection Materials For Use In Forensics And Diagnostics 2
... 31, 2012 /PRNewswire-iReach/ -- Global BioClinical (GBC) ... to the corporate team. Ms. Maas has joined GBC ... a Clinical Research Manager at Epigenomics, Inc., Ms. Maas ... responsible for a variety of clinical research studies, international ...
... According to a new market report published by ... Market (Surgical Sutures, Surgical Hand Instruments and Electrosurgical Devices) ... Analysis (2010 - 2017) "; the global surgical equipment ... is forecasted to reach USD 7.5 billion in 2017 ...
Cached Medicine Technology:Global BioClinical Welcomes Jennifer Maas as Senior Consultant 2Surgical Equipment Market (Surgical Sutures, Surgical Hand Instruments and Electrosurgical Devices) Estimated to Reach USD 7.5 Billion Globally in 2017: Transparency Market Research 2Surgical Equipment Market (Surgical Sutures, Surgical Hand Instruments and Electrosurgical Devices) Estimated to Reach USD 7.5 Billion Globally in 2017: Transparency Market Research 3Surgical Equipment Market (Surgical Sutures, Surgical Hand Instruments and Electrosurgical Devices) Estimated to Reach USD 7.5 Billion Globally in 2017: Transparency Market Research 4Surgical Equipment Market (Surgical Sutures, Surgical Hand Instruments and Electrosurgical Devices) Estimated to Reach USD 7.5 Billion Globally in 2017: Transparency Market Research 5
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: