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Biomarkers improve ischemic stroke prediction
Date:12/18/2008

uld eventually lead to more tailored treatment and preventative options," said Nambi.

Using only traditional risk factors, he and his colleagues defined those with a less than 2 percent chance of ischemic stroke in the next five years as low risk. Those with a 2 percent to 5 percent chance were defined as intermediate risk, and anyone with greater than a 5 percent chance of ischemic stroke were defined as high risk.

However, adding the biomarker data changed the risk category for some people. For example, 4 percent of people at low risk moved to intermediate risk while 11 percent in the intermediate group moved to high risk. However, 33 percent at high risk moved down to intermediate risk.

"While more studies must be done to determine if these categories can be used as a standard, these results show us one strategy to classify an individual's stroke risk and how this can be altered by the addition of novel blood tests," Nambi said. "By adding the two biomarkers we can better identify those at higher risk for stroke. Future studies should determine if changing treatment options based on risk could improve the prevention of ischemic stroke."

Dr. Christie M. Ballantyne, chief of atherosclerosis and vascular medicine at BCM and senior author of the study, added that "if we can identify who is at risk for a stroke, we have strong evidence that diet, exercise, smoking cessation and medicines for blood pressure and cholesterol will help to prevent stroke."


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Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

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