Navigation Links
Biomarkers for Alzheimer's disease can be trusted in clinical trials
Date:11/15/2007

Gteborg, Sweden, 15 November 2007 -- The best-established biomarkers for Alzheimers disease have a low natural variation over two years. The results speak for the inclusion of these biomarkers in clinical trials of novel drugs against Alzheimers disease.

The results are presented by researchers at the Sahlgrenska Academy at Gteborg University, Sweden, in the November 2007 issue of the Journal of Alzheimers Disease.

We show that the best-established diagnostic biomarkers for Alzheimers disease stay at basically the same level during two years in patients with early Alzheimers disease. This means that the biomarkers could be useful for detecting even minor biochemical changes induced by treatment in the clinical trials of novel drugs against Alzheimers, says Henrik Zetterberg, Associate Professor at the Sahlgrenska Academy.

Dr Zetterberg and colleagues analyzed cerebrospinal fluid from more than 80 patients with mild cognitive impairment. Some of these patients developed full-blown Alzheimers disease. The measured levels of the tau and amyloid- proteins were compared in samples drawn from the same patients two years apart.

If a novel drug candidate actually stops or slows down the neurodegenerative disease process in Alzheimer's disease, we should expect a normalized tau concentration in cerebrospinal fluid in patients on active treatment. Such a change should be readily detectable also in a small and inexpensive pilot study, given the low intra-individual variation in biomarker levels over time that was detected in our study, Dr Zetterberg says.

Alzheimer's disease is an age-related brain-damaging disorder that results in progressive cognitive impairment and death. Three decades of progress have resulted in a profound understanding of the molecular mechanisms underlying the disease. In the past 10 years, this knowledge has translated into a range of targets for therapy, the most promising of which is amyloid-.


'/>"/>

Contact: Associate Professor Henrik Zetterberg
henrik.zetterberg@clinchem.gu.se
46-313-430-142
IOS Press
Source:Eurekalert

Related medicine news :

1. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
2. Study makes progress in zoning in on biomarkers for better colon cancer treatment
3. Biomarkers predict risk for invasive breast cancer years before the tumor develops
4. JDRF and Lilly partner to fund research to identify beta cell biomarkers
5. Smoking may strongly increase long-term risk of eye disease
6. Pot bellies linked to early signs of cardiovascular disease
7. Anemia and tropical diseases; Is pharmacogenomics ready for the clinic?
8. Radiologists encouraged to look beyond cancer for clinically unseen diseases
9. Use of certain lipid measures not more effective in predicting coronary heart disease
10. Role seen for cannabis in helping to alleviate allergic skin disease
11. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... Datta Endoscopic ... has joined the revolutionary endoscopic practice under Dr. Datta. Patel is a Board ... Medicine. The patented, revolutionary eDiscSculpt Technique created and used by Datta Endoscopic is ...
(Date:4/28/2017)... Texas (PRWEB) , ... April 28, 2017 , ... The ... plaque in recently to the labor and delivery team at Women’s Hospital at Renaissance ... mothers who give birth at the hospital and decide to donate. , “Women’s ...
(Date:4/28/2017)... Yorba Linda, Ca (PRWEB) , ... April 28, ... ... entities with cardiac or hERG liability could substantially improve drug safety and minimize ... will be provided for validating ion channel inhibition using cell lines and for ...
(Date:4/28/2017)... ... April 28, 2017 , ... Bill Howe started his sewer ... coastal communities. After Tina Howe joined the team, the Bill Howe brand was born ... at affordable rates, and giving back to the San Diego community in which they ...
(Date:4/28/2017)... ... April 28, 2017 , ... Researchers at ... of ActiGraph’s CentrePoint Data Hub in a sample of participants enrolled ... wearable activity and sleep monitoring solutions for the global scientific community. The company’s ...
Breaking Medicine News(10 mins):
(Date:4/26/2017)... N.J. , April 26, 2017 Phoenix Marketing ... its fifteenth year of fulfilling its mission of transforming science ... is highly scrutinized, Phoenix,s innovative approach ... healthcare community about the latest advances in science and medicine ... Phoenix was founded in 2002 by Tracy ...
(Date:4/20/2017)... , April 20, 2017  Cogentix Medical, Inc. ... on providing the Urology, Uro/Gyn and Gynecology markets ... Ash Keswani has joined the Company as Senior ... newly created position, Mr. Keswani will report directly ... "Our organization is delighted that Ash ...
(Date:4/20/2017)... DUBLIN , April 20, 2017 Research ... Delivery Technologies - Innovation Driven by Rapidly Expanding Injectables Market and ... to their offering. ... market for drug delivery technologies will rise from USD 20 Billion ... Global Drug Delivery Technologies - Innovation Driven by Rapidly ...
Breaking Medicine Technology: