Navigation Links
Biomarkers for Alzheimer's disease can be trusted in clinical trials
Date:11/15/2007

Gteborg, Sweden, 15 November 2007 -- The best-established biomarkers for Alzheimers disease have a low natural variation over two years. The results speak for the inclusion of these biomarkers in clinical trials of novel drugs against Alzheimers disease.

The results are presented by researchers at the Sahlgrenska Academy at Gteborg University, Sweden, in the November 2007 issue of the Journal of Alzheimers Disease.

We show that the best-established diagnostic biomarkers for Alzheimers disease stay at basically the same level during two years in patients with early Alzheimers disease. This means that the biomarkers could be useful for detecting even minor biochemical changes induced by treatment in the clinical trials of novel drugs against Alzheimers, says Henrik Zetterberg, Associate Professor at the Sahlgrenska Academy.

Dr Zetterberg and colleagues analyzed cerebrospinal fluid from more than 80 patients with mild cognitive impairment. Some of these patients developed full-blown Alzheimers disease. The measured levels of the tau and amyloid- proteins were compared in samples drawn from the same patients two years apart.

If a novel drug candidate actually stops or slows down the neurodegenerative disease process in Alzheimer's disease, we should expect a normalized tau concentration in cerebrospinal fluid in patients on active treatment. Such a change should be readily detectable also in a small and inexpensive pilot study, given the low intra-individual variation in biomarker levels over time that was detected in our study, Dr Zetterberg says.

Alzheimer's disease is an age-related brain-damaging disorder that results in progressive cognitive impairment and death. Three decades of progress have resulted in a profound understanding of the molecular mechanisms underlying the disease. In the past 10 years, this knowledge has translated into a range of targets for therapy, the most promising of which is amyloid-.


'/>"/>

Contact: Associate Professor Henrik Zetterberg
henrik.zetterberg@clinchem.gu.se
46-313-430-142
IOS Press
Source:Eurekalert

Related medicine news :

1. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
2. Study makes progress in zoning in on biomarkers for better colon cancer treatment
3. Biomarkers predict risk for invasive breast cancer years before the tumor develops
4. JDRF and Lilly partner to fund research to identify beta cell biomarkers
5. Smoking may strongly increase long-term risk of eye disease
6. Pot bellies linked to early signs of cardiovascular disease
7. Anemia and tropical diseases; Is pharmacogenomics ready for the clinic?
8. Radiologists encouraged to look beyond cancer for clinically unseen diseases
9. Use of certain lipid measures not more effective in predicting coronary heart disease
10. Role seen for cannabis in helping to alleviate allergic skin disease
11. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... that co-occur frequently. While a significant number of women and men with eating ... the trauma itself, that best predicts the development of an eating disorder. ...
(Date:2/8/2016)... ... 08, 2016 , ... GrassrootsHealth published data from its D*action ... diabetes in the GrassrootsHealth cohort with substantially higher vitamin D levels than a ... health,” states Carole Baggerly, Director of GrassrootsHealth, “the safety and benefits of ...
(Date:2/8/2016)... Vegas, Nevada (PRWEB) , ... February 08, 2016 ... ... at RowdMap, Inc., will be speaking on how healthcare companies can use newly ... costs, manage the health of a population and intervene and capture the value ...
(Date:2/8/2016)... ... February 08, 2016 , ... According to research ... U.S. require dental technicians to be certified or obtain continuing education. To increase ... the “What’s In Your Mouth?” campaign to inform dentists and patients about the ...
(Date:2/7/2016)... ... February 07, 2016 , ... ... empowers employers and organizations with the tools and information to lower the costs, ... to cut the cost of providing employee healthcare benefits by as much as ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... Feb. 8, 2016 ... "Global Skin Protective Equipment Market 2016-2020" ... http://www.researchandmarkets.com/research/fqx6nz/global_skin ) has announced the addition of ... report to their offering. ... has announced the addition of the "Global ...
(Date:2/8/2016)... 8, 2016   HighPoint Solutions today ... (NRG),s pharmacovigilance technology services division.  NRG is a ... an Oracle Argus Specialized partner, providing drug safety ... companies. --> --> ... sciences capabilities and provides a global scale and ...
(Date:2/8/2016)... http://www.researchandmarkets.com/research/x6mkjm/knee ) has announced ... Market by Product Type (Primary (Cemented & Cementless), ... Eu-5, Japan, Bric, Turkey, Indonesia - Global Analysis ... offering. --> http://www.researchandmarkets.com/research/x6mkjm/knee ) has ... Devices Market by Product Type (Primary (Cemented & ...
Breaking Medicine Technology: