Navigation Links
Biomarkers discovered for inflammatory bowel disease
Date:5/21/2013

CINCINNATIUsing the Department of Defense Serum Repository (DoDSR), University of Cincinnati (UC) researchers have identified a number of biomarkers for inflammatory bowel disease (IBD), which could help with earlier diagnosis and intervention in those who have not yet shown symptoms.

This finding, the first of its kind and led by UC's Bruce Yacyshyn, MD, is being presented via podium presentation by staff from Walter Reed National Military Medical Center at Digestive Disease Week 2013, being held May 18-21 in Orlando, Fla.

The DoDSR is a biological repository operated by the U.S. Department of Defense and contains over 50 million human serum specimens, collected primarily from applicants to and members of the U.S. uniformed services.

"With collaborators from Walter Reed, we were able to identify all of the active duty service men and women who developed IBD and then used the repository to go back and look at various biomarkers to see what each person had in common," says Yacyshyn, a professor of medicine at the UC College of Medicine and UC Health gastroenterologist.

IBD is a group of inflammatory conditions of the colon and small intestine. The main types of IBD are Crohn's disease and ulcerative colitis; inflammatory bowel diseases are considered autoimmune diseases in which the body's own immune system attacks elements of the digestive system.

In this study, researchers used the repository to identify 50 cases of Crohn's disease and 50 cases of ulcerative colitis. They analyzed proteins from three samples per casetwo taken before and one after diagnosisusing a statistical analysis format.

Certain proteins were found in elevated levels in samples from patients who developed IBD.

"The selection of proteins we chose to analyze was based on a prior study conducted at UC," Yacyshyn says. "Although the presence of proteins in those who develop Crohn's disease varies from those present in ulcerative colitis patients, we were able to show that there were elevated levels of certain proteins in patients who developed IBD."

"Future large validation studies are needed to confirm the presence of biomarkers to guide in diagnosis, prevention and management of these patients," he adds.

Yacyshyn and his collaborators in the division of digestive diseases and at Cincinnati Children's Hospital Medical Center are hoping to study this further in a pediatric population and have requested funding from the Crohn's and Colitis Foundation.

"This could change the way we currently screen for and treat IBD, which could improve prevention strategies, patient outcomes and their overall quality of life," he says.

This study was investigator-initiated.


'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center
Source:Eurekalert

Related medicine news :

1. Biomarkers can reveal IBS
2. Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
3. Novel biomarkers reveal evidence of radiation exposure
4. Using biomarkers to identify and treat schizophrenia
5. US Army: Pre-injury cartilage biomarkers associated with subsequent ACL injuries
6. Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
7. Tracking down smallest biomarkers
8. Metabolic biomarkers for preventive molecular medicine
9. Kentucky team inhibits Alzheimers biomarkers in animal model by targeting astrocytes
10. NIH launches collaborative effort to find biomarkers for Parkinsons
11. Mayo Clinic-led study identifies biomarkers for early risk assessment of acute kidney injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: