Navigation Links
Biomarkers discovered for inflammatory bowel disease
Date:5/21/2013

CINCINNATIUsing the Department of Defense Serum Repository (DoDSR), University of Cincinnati (UC) researchers have identified a number of biomarkers for inflammatory bowel disease (IBD), which could help with earlier diagnosis and intervention in those who have not yet shown symptoms.

This finding, the first of its kind and led by UC's Bruce Yacyshyn, MD, is being presented via podium presentation by staff from Walter Reed National Military Medical Center at Digestive Disease Week 2013, being held May 18-21 in Orlando, Fla.

The DoDSR is a biological repository operated by the U.S. Department of Defense and contains over 50 million human serum specimens, collected primarily from applicants to and members of the U.S. uniformed services.

"With collaborators from Walter Reed, we were able to identify all of the active duty service men and women who developed IBD and then used the repository to go back and look at various biomarkers to see what each person had in common," says Yacyshyn, a professor of medicine at the UC College of Medicine and UC Health gastroenterologist.

IBD is a group of inflammatory conditions of the colon and small intestine. The main types of IBD are Crohn's disease and ulcerative colitis; inflammatory bowel diseases are considered autoimmune diseases in which the body's own immune system attacks elements of the digestive system.

In this study, researchers used the repository to identify 50 cases of Crohn's disease and 50 cases of ulcerative colitis. They analyzed proteins from three samples per casetwo taken before and one after diagnosisusing a statistical analysis format.

Certain proteins were found in elevated levels in samples from patients who developed IBD.

"The selection of proteins we chose to analyze was based on a prior study conducted at UC," Yacyshyn says. "Although the presence of proteins in those who develop Crohn's disease varies from those present in ulcerative colitis patients, we were able to show that there were elevated levels of certain proteins in patients who developed IBD."

"Future large validation studies are needed to confirm the presence of biomarkers to guide in diagnosis, prevention and management of these patients," he adds.

Yacyshyn and his collaborators in the division of digestive diseases and at Cincinnati Children's Hospital Medical Center are hoping to study this further in a pediatric population and have requested funding from the Crohn's and Colitis Foundation.

"This could change the way we currently screen for and treat IBD, which could improve prevention strategies, patient outcomes and their overall quality of life," he says.

This study was investigator-initiated.


'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center
Source:Eurekalert

Related medicine news :

1. Biomarkers can reveal IBS
2. Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
3. Novel biomarkers reveal evidence of radiation exposure
4. Using biomarkers to identify and treat schizophrenia
5. US Army: Pre-injury cartilage biomarkers associated with subsequent ACL injuries
6. Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
7. Tracking down smallest biomarkers
8. Metabolic biomarkers for preventive molecular medicine
9. Kentucky team inhibits Alzheimers biomarkers in animal model by targeting astrocytes
10. NIH launches collaborative effort to find biomarkers for Parkinsons
11. Mayo Clinic-led study identifies biomarkers for early risk assessment of acute kidney injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, ... Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms ... Final Cut Pro X . Simply select a ProHand generator and drag it above ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... FRANCISCO, Calif. , June 24, 2016 /PRNewswire/ ... ), a biopharmaceutical company developing novel therapeutics for ... unmet needs, today announced the closing of its ... of common stock, at the public offering price ... in the offering were offered by GBT. GBT ...
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
Breaking Medicine Technology: