Navigation Links
Biomarkers May Predict Alzheimer's
Date:7/21/2009

Proteins in spinal fluid may help diagnose disease early, study shows,,

TUESDAY, July 21 (HealthDay News) -- Certain proteins found in cerebrospinal fluid may accurately identify the people with mild cognitive impairment who are most likely to develop Alzheimer's disease, a new study finds.

Changes in the chemistry of cerebrospinal fluid have been identified as early signs of Alzheimer's disease. If and when treatments are available for Alzheimer's, diagnosing the disease early may help prevent it from developing, experts say.

"We confirmed, in a large multi-center study, that proteins in cerebrospinal fluid identify early-stage Alzheimer's disease, as suggested by previous smaller studies," said lead researcher Dr. Niklas Mattsson, from the Institute of Neuroscience and Physiology, Clinical Neurochemistry Laboratory at Sahlgrenska University Hospital in Molndal, Sweden.

"These proteins may be used in research, in particular in drug trials, and also as a complement to clinical diagnostics, in particular when disease-modifying drugs become available," he said.

The report is published in the July 22/29 issue of the Journal of the American Medical Association.

For the study, Mattsson's team studied the accuracy of using three biomarkers found in spinal fluid in predicting Alzheimer's diseases. The biomarkers are beta-amyloid1-42 (Aβ42), total tau protein (T-tau), and tau phosphorylated at position threonine 181 (P-tau).

The researchers tested for these biomarkers in 750 people with mild cognitive impairment, 529 people with Alzheimer's disease and 304 healthy people. After two years, 271 of those with mild cognitive impairment progressed to Alzheimer's disease and 59 developed other dementias.

The researchers found that people who developed Alzheimer's had lower levels of Aβ42 and higher levels of P-tau and T-tau compared with patients with mild cognitive impairment who did not develop Alzheimer's.

Mattsson's group found these biomarkers were highly accurate in predicting which patients would develop Alzheimer's disease. "The cerebrospinal fluid proteins Aβ42, T-tau, and P-tau are useful in diagnosis of early-stage Alzheimer's disease," Mattsson noted.

Dr. Sam Gandy, the Mount Sinai Professor in Alzheimer's Disease Research at Mount Sinai School of Medicine in New York City, said this study really quantifies the accuracy of these tests in predicting Alzheimer's.

"There have been a number of smaller reports that Aβ falls and P-tau rises as the clinical course progresses from aging to mild cognitive impairment to Alzheimer's," Gandy said. "The sensitivities and specificities of these smaller studies have varied widely."

This larger study is definitive in establishing sensitivity and specificity that are somewhat lower than those reported by the smaller studies, Gandy said. "The larger study also points up the importance of harmonizing assays across multiple study sites in order to optimize the sensitivity and specificity."

Maria Carrillo, director of medical and scientific relations at the Alzheimer's Association, hopes that one day Alzheimer's can be screened for as routinely as cholesterol levels are checked today.

"We are very excited that cerebrospinal fluid biomarkers are holding up in terms of their specificity and sensitivity in diagnosing the disease early," Carrillo said. "The next step is to make sure these tests are standardized so that the test will mean the same thing, no matter where it is taken."

If these tests are standardized, it could be a biomarker that identifies the disease, Carrillo said. "If over the next two or three years we also have a therapy, then we need to examine how that therapy works in an incipient form of Alzheimer's, not once those memories have already started fading," she said.

More information

For more information on Alzheimer's disease, visit the Alzheimer's Association.



SOURCES: Niklas Mattsson, M.D., Institute of Neuroscience and Physiology, Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden; Maria Carrillo, Ph.D., director, medical and scientific relations, Alzheimer's Association; Samuel Gandy, M.D., Ph.D., Mount Sinai Professor in Alzheimer's Disease Research, Mount Sinai School of Medicine, New York City; July 22/29, 2009, Journal of the American Medical Association


'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. DiaGenic to Provide MCI Biomarkers for Merz Pharmaceuticals
2. Biomarkers predict brain tumors response to therapy
3. Novel biomarkers in heart failure
4. Biomarkers May Help Measure Rate of Decline in Dementia
5. Interleukin Genetics to Chair Expert Panel Discussion on Use of Biomarkers in Drug Development at BIO Convention
6. BioTech Firm Decodes Current Swine Flu BioMarkers
7. Biomarkers May Predict Aggressiveness of Prostate Cancer
8. Vitamin D Linked to HDL Cholesterol - Shaklee Corporation Research Links Vitamin D with Key Biomarkers for Metabolic Syndrome and Heart Disease
9. Potential lung disease biomarkers yield clues to COX-2 inhibitor side effects
10. Cordex Pharma to Collaborate with BG Medicine in a Clinical Study of Heart Failure Biomarkers
11. Biomarkers detected for Chikungunya fever
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Biomarkers May Predict Alzheimer's 
(Date:2/27/2017)... ... February 27, 2017 , ... ... body strength, which often leads to a host of health issues, including urinary ... American Geriatrics Society discovered that good overall muscle strength in older women, ...
(Date:2/27/2017)... RICHEY, Fla. (PRWEB) , ... February 27, 2017 , ... ... disorder, but concern for women who become dependent on opioid painkillers has fallen short. ... female patients, compared to a 237% increase in fatal overdoses in male populations.(1) , ...
(Date:2/27/2017)... ... February 27, 2017 , ... ... overview on laser diffraction analysis as a tool to characterize particle size distributions ... potential to obtain improved results and novel scientific findings. It describes methods of ...
(Date:2/27/2017)... Vancouver, BC (PRWEB) , ... February 27, 2017 ... ... top drug rehabilitation and alcohol treatment programs in British Columbia, Canada, at ... (RMT) to its team. The new hire, Mackenzie Alsager, showcases the Centre's commitment ...
(Date:2/26/2017)... ... February 25, 2017 , ... The February 13, 2017, assassination of ... concern over nerve agents and the deadly use of chemical weapons. Many questions exist ... how even small doses can be lethal. , Jay Jagannathan, M.D., of Michigan-based Jagannathan ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Feb. 24, 2017 Research and Markets has ... & Trends - Industry Forecast to 2025" report to their ... The ... of around 23.8% over the next decade to reach approximately $330.5 ... estimates and forecasts for all the given segments on global as ...
(Date:2/24/2017)... and Markets has announced the addition of the "Dry eye Drugs ... ... Drugs Price Analysis and Strategies - 2016, provides drug pricing data and ... following questions: What are the key drugs ... in the Global Dry eye market? What are the ...
(Date:2/24/2017)... NEW YORK , Feb. 24, 2017 ... Monteverde & Associates PC , a boutique securities ... New York City , announces that a ... of Massachusetts  against Inotek Pharmaceuticals ... purchasers of the Company,s securities between July 23, 2015 and ...
Breaking Medicine Technology: