Navigation Links
'Biomarkers' May Help Spot, Track Alzheimer's
Date:7/29/2008

A number of molecules in blood and spinal fluid seem likely candidates, researchers say

TUESDAY, July 29 (HealthDay News) -- Scientists may be succeeding in the hunt for biomarkers for Alzheimer's disease.

A biomarker -- something that can be measured and that gives an indication of what's going on inside the body -- will help in early detection, in testing new therapies and, once doctors have better drugs for Alzheimer's, with earlier intervention in the disease process.

"If we're going to have any kind of medication that alters or modifies the disease, if it's really going to change it rather than treat symptoms, then we need biomarkers that are sensitive to the illness before a person becomes impaired," explained Dr. Gary Kennedy, director of geriatric psychiatry at Montefiore Medical Center in New York City. "In Alzheimer's, we need two things: We need to know who's sick and who's not and, secondly, biomarkers should be treatment-sensitive, meaning if you've got the right treatment, you watch the biomarker go down, like blood sugar and insulin. That's the model we want."

One study being presented at the International Conference on Alzheimer's Disease (ICAD) in Chicago found that differences in levels of CD-69, a protein involved in white blood cell growth and production, allowed researchers to distinguish between people with Alzheimer's, people with Parkinson's-related dementia and those who were cognitively normal.

The study, from researchers at the University of Leipzig in Germany, was based on a theory that Alzheimer's occurs when neurons get a false signal to divide. The more popular theory holds that a build-up of amyloid plaque (made up mostly of beta amyloid protein) in the brain causes Alzheimer's.

"The alternative theory about Alzheimer's is that the [cell] replication process gets triggered pathologically, and then the cells are programmed to die, and that's what's killing the nerve cells, not the amyloid," Kennedy explained. "[This study] all hinges on the theory that it's a false signal to replicate that starts these neurons down the path to killing themselves."

But investigators still have a long way to go. "It's one thing to distinguish the sick group from the healthy group and another to see if you can predict from the healthy group who gets the disease," Kennedy said. "That's the real proof of the pudding."

A second study, from researchers at Washington University in St. Louis, confirmed previous findings: that the more amyloid there is in the brain (as measured by PET scans), the less beta amyloid 42 there is in cerebrospinal fluid (CSF). Beta amyloid 42 is an extra-"sticky" type of amyloid protein which accumulates and forms plaques. The theory is that measurements of beta amyloid 42 in spinal fluid could serve as a marker for Alzheimer's disease.

Another study, this time from a team in Ireland and in Germany, found that individuals with mild cognitive impairment (MCI), often considered a transitional stage between normal cognitive functioning and Alzheimer's, had elevated levels of beta-secretase (BACE1) activity in the brain when compared both to healthy people and people with Alzheimer's.

Finally, a fourth study showed that a certain radioactive compound or tracer, 18F-AV-45, may have potential in the diagnosis and early detection of Alzheimer's when used with PET scans. Trials of the substance, conducted by Philadelphia-based Avid Radiopharmaceuticals Inc., are ongoing.

More information

For more on Alzheimer's, visit the Alzheimer's Association.



SOURCES: Gary J. Kennedy, M.D., director, geriatric psychiatry, Montefiore Medical Center, New York City; presentations, 2008 International Conference on Alzheimer's Disease, Chicago


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
2. Study makes progress in zoning in on biomarkers for better colon cancer treatment
3. Biomarkers predict risk for invasive breast cancer years before the tumor develops
4. JDRF and Lilly partner to fund research to identify beta cell biomarkers
5. Biomarkers for Alzheimers disease can be trusted in clinical trials
6. New developments in biomarkers for epithelial ovarian cancer
7. Proteomic profiling shown more accurate than traditional biomarkers in identifying liver cancer
8. UCLA researchers discover biomarkers that predict lung cancer patient response to therapy
9. Biomarkers for Mood May Alter Psychiatric Treatments
10. Biomarkers and Innovation Push Global Cancer Diagnostics Market Toward $8 Billion
11. Scientists: New technique identifies molecular biomarkers for disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Biomarkers' May Help Spot, Track Alzheimer's
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , ... Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , ... our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of ... of the latter, setting the bar too high can result in disappointment, perhaps even ... progress toward their goal. , Research from PsychTests.com reveals that behind ...
(Date:6/24/2016)... ... 2016 , ... Marcy was in a crisis. Her son James, eight, was out of control. ... and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... rocks at my other children and say he was going to kill them. If ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Comfort Keepers® of ... Cancer Society and the Road To Recovery® program to drive cancer patients to and ... other adults to ensure the highest quality of life and ongoing independence. Getting ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at www.diabetesscholars.org by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
(Date:6/23/2016)... , June 23, 2016 ... Oticon , industry leaders in advanced ... launch of Oticon Opn ™, the world,s first ... of possibilities for IoT devices.      (Photo: ... Oticon introduces a number of ,world firsts,: ...
(Date:6/23/2016)... , June 23, 2016 The vast majority ... outpatient dialysis facility.  Treatments are usually 3 times a ... per visit, including travel time, equipment preparation and wait ... but especially grueling for patients who are elderly and ... skilled nursing and rehabilitation centers for some duration of ...
Breaking Medicine Technology: