Navigation Links
Biomarker predicts risk of breast cancer recurrence after tamoxifen treatment
Date:6/28/2013

A biomarker reflecting expression levels of two genes in tumor tissue may be able to predict which women treated for estrogen-receptor (ER)-positive breast cancer should receive a second estrogen-blocking medication after completing tamoxifen treatment. In their report being published online in the Journal of the National Cancer Institute, Massachusetts General Hospital (MGH) Cancer Center investigators describe finding that the HOXB13/IL17BR ratio can indicate which women are at risk for cancer recurrence after tamoxifen and which are most likely to benefit from continuing treatment with the aromatase inhibitor letrozole (Femara).

"Most patients with early-stage, ER-positive breast cancer remain cancer-free after five years of tamoxifen treatment, but they remain at risk of recurrence for 15 years or longer after their initial treatment," says Dennis Sgroi, MD, of the MGH Cancer Center and Department of Pathology, lead and corresponding author of the report. "Our biomarker identifies the subgroup of patients who continue to be at risk of recurrence after tamoxifen treatment and who will benefit from extended therapy with letrozole, which should allow many women to avoid unnecessary extended treatment."

Previous research by Sgroi's team, in collaboration with investigators from bioTheranostics Inc., discovered that the ratio between levels of expression of two genes HOXB13 and IL17BR in tumor tissue predicted the risk of recurrence of ER-positive, lymph-node-negative breast cancer, whether or not the patient was treated with tamoxifen. The current study of patients from MA.17, the highly successful clinical trial of letrozole, was designed to evaluate the usefulness of the HOXB13/IL17BR ratio for both prognosis predicting which tamoxifen-treated remained patients at risk of recurrence and for identifying who could benefit from continued treatment with letrozole.

To answer those questions the investigators analyzed prim
'/>"/>

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New concussion data: 2 biomarkers better than 1
2. MET protein levels show promise as biomarker for aggressive colon cancer
3. Researchers narrow the search for biomarkers of drug resistance in head and neck cancer patients
4. Kantar Health Launches CancerMPact Biomarker Analysis
5. Biomarkers discovered for inflammatory bowel disease
6. Leading researchers report on the elusive search for biomarkers in Huntingtons disease
7. The search for an early biomarker to fight atherosclerosis
8. VEGF may not be relevant biomarker for advanced prostate cancer
9. Possible predictive biomarker for patients who may respond to autophagy inhibitors
10. Office workers carry biomarker of potentially harmful flame retardant, study finds
11. Trio of biomarkers may help identify kidney cancer in early stages
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... ... , ... NJ Top Dentist, Dr. Susan Goldfarb, had a very busy professional ... members of the Bergen County Dental Society. She does this every year to ... Healthcare Providers. Life Support from Hackensack Hospital provided the instructors and she provided ...
(Date:6/30/2015)... MO (PRWEB) , ... June 30, 2015 , ... ... handling national testosterone claims alleging heart attack and stroke incidents are linked to ... Independence Day. The Case Management Conference is scheduled for July 9, 2015, according ...
(Date:6/30/2015)... , ... June 30, 2015 , ... Harbor Village ... affordable addiction care in Florida on June 12th. Holly Vasquez-Cortella was recently ... - a website dedicated to reporting on trending addiction news and treatment innovations. ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... Wagner, Chief Research and Strategy Officer at Predictive Analytics Reporting (PAR) Framework, and ... Science Foundation (NSF), will provide keynote addresses at the 2015 STEMtech conference in ...
(Date:6/30/2015)... ... ... campaign aims to make digestive wellness a more conversational topic, educating on the importance ... face and inspiring readers to be more proactive by providing them the tools they ... Wellness” is distributed within USA Today in Los Angeles, New York, Chicago, Miami and ...
Breaking Medicine News(10 mins):Health News:NJ Top Dentists Presents, Dr. Susan Goldfarb of Advanced Periodontics & Implant Care! 2Health News:NJ Top Dentists Presents, Dr. Susan Goldfarb of Advanced Periodontics & Implant Care! 3Health News:Testosterone Lawsuit News: July Conference on Bellweather Trials 2Health News:Testosterone Lawsuit News: July Conference on Bellweather Trials 3Health News:Testosterone Lawsuit News: July Conference on Bellweather Trials 4Health News:Harbor Village Detox’s Clinical Director Is Quoted as an Addiction Expert by The Fix 2Health News:Harbor Village Detox’s Clinical Director Is Quoted as an Addiction Expert by The Fix 3Health News:League for Innovation Announces Distinguished Keynote Presenters for STEMtech Conference 2Health News:League for Innovation Announces Distinguished Keynote Presenters for STEMtech Conference 3Health News:Mediaplanet’s “Digestive Wellness” Campaign Urges You To Listen to What Your Stomach Is Telling You and Talk About It 2
... Almost Family, Inc. (Nasdaq: AFAM ), a leading regional provider of ... Chief Financial Officer, is scheduled to present at the 27th Annual J.P. Morgan ... Event: 27th Annual J.P. Morgan ... Wednesday, January 14, 2009, Time: ...
... Christmas cookies, eggnog, juicy beef roast, rich gravy ... unfortunately can send blood cholesterol levels sky high. ... new weapon -- synthetic high-density lipoprotein (HDL), the ... high cholesterol levels and the deadly heart disease ...
... French . , Scientists from McGill ... Douglas Mental Health University Institute earn top marks in ... for their groundbreaking work. , Published in the magazine,s ... Alain Brunet, The Douglas/McGill Faculty of Medicine, Psychiatry; McGill ...
... average of 300 calories every day, study finds, , , FRIDAY, ... soda and coffee drinks have become a staple of your ... may make you drop that super-sized, sweetened beverage. , Published ... of Clinical Nutrition , the research found that people are ...
... Gynecologic Oncologists (SGO) will host its 40th Annual Meeting ... B. Gonzalez Convention Center in San Antonio, Texas. ... presentations in addition to lectures, workshops, symposia, surgical labs ... trials and treatment advances for physicians and health care ...
... Jan. 9 Pierre,s Ice Cream Company, makers ... launching another innovation,called Yovation(TM). , ... Yovation(TM) is a new premium, ... consumer interest and popularity of probiotic products and ...
Cached Medicine News:Health News:Synthetic HDL: A new weapon to fight cholesterol problems 2Health News:McGill, MUHC and Douglas researchers get top marks from Quebec Science magazine 2Health News:McGill, MUHC and Douglas researchers get top marks from Quebec Science magazine 3Health News:Americans Consuming More Sugary Beverages 2Health News:Americans Consuming More Sugary Beverages 3Health News:Society of Gynecologic Oncologists to Host 40th Annual Meeting on Women's Cancer 2Health News:Standing Ovation for Pierre's New Innovation! 2Health News:Standing Ovation for Pierre's New Innovation! 3
(Date:6/30/2015)... -- Pulse Light Clinic in London,s ... as part of their ongoing research into the condition. They ... their Rosacea. The survey participants were aged between 20 and ... women. The results revealed some rather surprising statistics: ... attempt to visit their GP for Rosacea treatment. ...
(Date:6/30/2015)... 30, 2015 First Choice Wellness Care recently ... Duality and is the only clinic in the greater ... removal treatments. The practice has recently expanded their services ... to showcase their focus in the procedure. They upgraded ... faster ink clearance, and superior service. "We,ve ...
(Date:6/30/2015)... 2015  Avanir Pharmaceuticals, Inc. today announced top-line ... treatment with NUEDEXTA ® was associated with ... affect (PBA) in patients with traumatic brain injury ... characterized by sudden and uncontrollable outbursts of laughing ... brain injury. PRISM II is a phase IV ...
Breaking Medicine Technology:84% of Rosacea Sufferers Say NHS Treatments Were "Ineffective" New Survey Reveals 284% of Rosacea Sufferers Say NHS Treatments Were "Ineffective" New Survey Reveals 3First Choice Wellness Care Becomes Tallahassee Leader In Tattoo Removal With Astanza Duality 2First Choice Wellness Care Becomes Tallahassee Leader In Tattoo Removal With Astanza Duality 3Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 2Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 3Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 4Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 5Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 6Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 7
... 2011 Fuisz ( www.fuisz.com ) today announced the ... Permitting Stage Door Access to On-Line Vendor Information"). ... "This patent covers a system that allows a customer ... a product supplier database through the on-line vendor,s system ...
... 15, 2011 Cardium Therapeutics (NYSE Amex: ... from the Russian Ministry of Health and Social Development ... Company,s Generx™ (alferminogene tadenovec, Ad5FGF-4) biologic product candidate.  Generx ... for the potential treatment of myocardial ischemia due to ...
Cached Medicine Technology:Generx DNA-Based Angiogenic Therapy Receives Russian Ministry of Health Clearance for Late-Stage Registration Clinical Study for Coronary Artery Disease 2Generx DNA-Based Angiogenic Therapy Receives Russian Ministry of Health Clearance for Late-Stage Registration Clinical Study for Coronary Artery Disease 3Generx DNA-Based Angiogenic Therapy Receives Russian Ministry of Health Clearance for Late-Stage Registration Clinical Study for Coronary Artery Disease 4Generx DNA-Based Angiogenic Therapy Receives Russian Ministry of Health Clearance for Late-Stage Registration Clinical Study for Coronary Artery Disease 5Generx DNA-Based Angiogenic Therapy Receives Russian Ministry of Health Clearance for Late-Stage Registration Clinical Study for Coronary Artery Disease 6Generx DNA-Based Angiogenic Therapy Receives Russian Ministry of Health Clearance for Late-Stage Registration Clinical Study for Coronary Artery Disease 7
... D-Type can combine a number of ... microplates on a simple to use ... is a multifunctional stand-alone device but ... robotic systems. Custom and standard add-on ...
Grab one and go, One of the smallest handheld oximeters available, Datex-Ohmeda s TuffSat is the ideal spot-check solution for hospital, home care, transport, and EMS. TuffSat comes fully loaded wi...
Smith & Nephew's CDS System is developed exclusively for discography., Developed exclusively for discography, it is the first system designed to measure true disc pressure and record real-time proce...
The Maxi-Therm® lite hyper-hypothermia water blankets from Cincinnati Sub-Zero take conductive warming and cooling therapy to a new, softer level. These blankets are soft, lightweight, and remai...
Medicine Products: