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Biomarker predicts response to cancer treatment
Date:5/21/2012

emo)therapy. The monoclonal antibody bevacizumab neutralizes the wild growth of blood vessels triggered by the tumor in support of its aggressive growth. Currently studies are under way to determine whether bevacizumab could also be used for other cancers."

DNA variants

Diether Lambrechts and Bart Claes (VIB/KU Leuven) looked at blood samples from cancer patients participating in 2 clinical studies and receiving bevacizumab or a placebo in addition to standard treatment. They subsequently looked for genetic variations in the DNA that could predict specifically how long patients survived in the group treated with bevacizumab but not in the placebo group. This is how they came upon a variant that showed predictive value for treatment with bevacizumab. These findings are a nice result of all efforts being done to identify a biomarker for bevacizumab.

More research necessary

The results of this study are well advanced but not final. Additional studies are needed to further validate the findings scientifically. However, it is a promising start for the personalized use of this drug. And it should be noted here that biomarkers like these do not only benefit patients but, given the high price of new cancer drugs, will help keep healthcare affordable.


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Contact: Sooike Stoops
sooike.stoops@vib.be
32-924-46611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

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