Navigation Links
Biomarker predicts response to cancer treatment
Date:5/21/2012

Leuven, 21 mei 2012 - VIB researcher Diether Lambrechts, associated with KU Leuven, has discovered a biomarker that might potentially predict which patients will benefit more from treatment with bevacizumab (Avastin). If validated, this discovery could be an important step towards personalized medicine and patient-tailored use of this important cancer drug.

Diether Lambrechts (VIB KU Leuven) said "in two large clinical studies with patients with advanced stages of pancreas and kidney cancer a variant in the DNA was discovered that identified patients who did not respond well to the prescribed course of bevacizumab. Further research in the lab showed that this variant, or biomarker, was responsible for increasing the production of a certain protein that is hypothesized to neutralize the effect of bevacizumab in these patients. If this marker would be clinically validated, the marker could be used to distinguish patients that would benefit from the drug from those that would not, and spare them a futile therapy with possible side effects."

Biomarkers for targeted treatments

Oncologists want to use treatments that target the particular cancer. Every cancer is characterized by a specific set of proteins that is responsible for the abnormal behavior of the tumor. Therapies aimed at blocking these proteins can significantly extend the life of cancer patients, provided that they receive the drug that is right for them. Cancers with a different set of proteins will not respond to a therapy that does not target those proteins. That is why developing biomarkers for all targeted therapies is so important.

An antibody as cancer drug

Eric Van Cutsem (UZ Leuven) explains that "Bevacizumab is a targeted therapy but there is no clinically validated biomarker yet. In clinical practice, patients in the advanced stages of colon, renal, lung and breast cancer are already being given bevacizumab in addition to their conventional (ch
'/>"/>

Contact: Sooike Stoops
sooike.stoops@vib.be
32-924-46611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New biomarker test predicts arthritis at much earlier stage, MU researchers say
2. Early biomarker for pancreatic cancer identified
3. Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
4. Biomarkers can reveal IBS
5. SomaLogic publishes proteomic biomarker analysis of lung cancer tissue samples
6. Biomarker identified in relation to drug response in refractory urothelial cancer
7. Panel of serum biomarkers may reduce number of lung biopsies needed
8. Biomarkers identify acute kidney injury in emergency patients
9. Genetic sequencing could help match patients with biomarker-driven cancer trials, treatments
10. Metabolic syndrome biomarkers predict lung function impairment after exposure to WTC dust
11. Mass. General Cancer Center and Vall dHebron Institute of Oncology biomarker alliance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2015)... GoHooper.com announces new website for Grace Pediatrics. Grace ... infants, children and adolescents and partners with parents to ... owner/provider Mark Hughes, MD, FAAP and a his team ... in the extensive range of pediatric care from newborn ... who meet the medical field's highest standards, and who ...
(Date:3/30/2015)... FL (PRWEB) March 30, 2015 Wimbledon ... provides vascular, echocardiogram and NCV ... national affiliated physicians in observance of National Doctor’s Day. ... day around our office, but on this day, we ... the important role they play in healing patients, promoting ...
(Date:3/30/2015)... March 30, 2015 In its 2015 ... ranked Robins & Morton sixth among the top general ... & Morton has specialized in healthcare construction for more ... Robins & Morton ranked on the list with $657 ... The company built 2.6 million square feet with 82 ...
(Date:3/30/2015)... 30, 2015 Textile Exchange, a global ... industry, today announced the latest version of its ... standard that can be applied to any waterfowl-based supply ... hatchling to end product. The goal of the RDS ... welfare and to enable traceability so that products can ...
(Date:3/30/2015)... March 30, 2015 On March 11, 2015, ... Blast Away Fat,” details six new treatment options for dealing ... and one is a topical product. The other three technologies ... Liposonix ) or freezing cold ( CoolSculpting ) to ... options now available to us to permanently remove unwanted fat," ...
Breaking Medicine News(10 mins):Health News:Nashville Web Design Company Announces New Site Launch For Pediatrics Doctor 2Health News:Wimbledon Health Partners Recognizes National Doctors’ Day 2Health News:Modern Healthcare Ranks Robins & Morton No. 6 Contractor 2Health News:Responsible Down Standard 2.0 Released 2Health News:Responsible Down Standard 2.0 Released 3Health News:UltraShape and CoolSculpting: Two New Fat-Busting Technologies 2
... Medical Center the focus on quality, patient safety and ... but measureable, quantifiable and concrete. Patients and health care ... and operational transparency in the Department of Orthopaedic Surgery,s ... now available online as well as in hard copy ...
... the strongest known risk factors for spontaneous or unexpected preterm ... of pregnancy, most often without a known cause is ... would like to avoid this scenario in their second pregnancy, ... the best strategy. A new study reported at the Society ...
... of the Indian curry spice turmeric, may help slow ... androgen deprivation therapy (ADT), a study from researchers at ... Reporting in a recent issue of Cancer Research ... Cancer Biology, Urology and Radiation Oncology at Thomas ...
... , THURSDAY, Feb. 9 (HealthDay News) -- Getting behind the ... driver,s risk of having an accident, a large new research ... crashes, and the risk is only a little less than ... "On the whole, alcohol increases the risk of a crash ...
... Meeting of the American Academy of Orthopaedic Surgeons (AAOS) ... with a total knee replacement (TKR), as the number ... past decade, with the sharpest rise among younger patients. ... Investigators used a computer model; U.S. Census data; information ...
... (February 10, 2012) In a study to be ... meeting, The Pregnancy Meeting , in Dallas, Texas, researchers ... stem cells into the lateral ventricles of neonatal rats ... donor cells can survive and migrate in the recipient,s ...
Cached Medicine News:Health News:Orthopaedic surgery report provides transparency on patient safety, quality initiatives 2Health News:To avoid early labor and delivery, weight and diet changes not the answer 2Health News:Curry spice component may help slow prostate tumor growth 2Health News:Pot Use Could Double Risk of Car Crash, Research Shows 2Health News:Pot Use Could Double Risk of Car Crash, Research Shows 3Health News:Pot Use Could Double Risk of Car Crash, Research Shows 4Health News:4.5 million Americans living with total knee replacement 2Health News:Neurologic improvement detected in rats receiving stem cell transplant 2
(Date:3/30/2015)... DUBLIN , Mar. 26, 2015 Research ... announced the addition of the "Computer Aided ... report to their offering. Annual estimates ... through 2020. Also, a six-year historic analysis is ... are derived from primary and secondary research. Company ...
(Date:3/30/2015)... -- Check-Cap Ltd. (NASDAQ: CHEK ), a clinical stage ... preparation-free ingestible imaging capsule that utilizes low-dose X-rays for ... Guy Neev , will ring the closing bell ... Check-Cap will participate in the closing bell ceremonies at ... simultaneous private placement which raised a total of $24 ...
(Date:3/30/2015)... -- Building on the momentum of the first quarter of 2015, ... systems, has announced aggressive plans to expand its Medicaid Home ... business models. The first quarter addition of new ... and Louisiana is a ... statewide coverage in each state. This brings the total to ...
Breaking Medicine Technology:Computer Aided Detection (CAD) - Global Strategic Business Report 2015-2020: Rising Incidence of Cancer - A Major Market Driver 2Computer Aided Detection (CAD) - Global Strategic Business Report 2015-2020: Rising Incidence of Cancer - A Major Market Driver 3Computer Aided Detection (CAD) - Global Strategic Business Report 2015-2020: Rising Incidence of Cancer - A Major Market Driver 4Check-Cap to Celebrate Initial Public Offering with NASDAQ Closing Bell Ceremony on March 31, 2015 2Check-Cap to Celebrate Initial Public Offering with NASDAQ Closing Bell Ceremony on March 31, 2015 3MedScope's Aggressive 2015 Expansion Focuses on Medicaid Waiver and Managed Care Organizations 2
... WASHINGTON, Nov. 20 Pharmaceutical,researchers are testing 92 ... related conditions, according to a report released today ... December,1 marks the 20th anniversary of "World AIDS ... the 1988 World Summit of Ministers of Health ...
... in Non-Small Cell Lung Cancer Expected to Inform ... for Experimental Cancer Treatment, MOUNTAIN VIEW, Calif., ... a leading provider of software,strategic consulting, and regulatory ... its Strategic Consulting Services Group,is using a quantitative ...
Cached Medicine Technology:92 Medicines and Vaccines now in Development for HIV/AIDS 292 Medicines and Vaccines now in Development for HIV/AIDS 3Pharsight Uses FDA Disease Model to Support Oncology Drug Development 2Pharsight Uses FDA Disease Model to Support Oncology Drug Development 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: