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Biomarker may be an early predictor of advanced breast cancer
Date:11/5/2007

ples, they found that osteopontin-c was present in 78 percent of cancers and in 36 percent of the surrounding tissues. It was not detected at all in normal tissues.

In 56 breast cancers, 20 were positive and 36 were negative for estrogen receptor, 19 were positive and 37 were negative for progesterone receptor, and 26 were positive for HER2 with 30 negative.

Osteopontin-c was present in a substantially higher number of breast cancers than the three biomarkers traditionally used to diagnose breast cancer, says Weber. We also found that the cancers containing osteopontin-c correlated with a higher tumor grade, meaning they were more likely to become aggressive cancer.

If we know that this molecule is not present in a patient with breast cancer, its more likely that we can treat them with conservative therapy rather than breast surgery, hormone therapy or chemotherapy because we know its less likely to metastasize, he adds. On the other hand, if we know that a patient has this molecule early in their diagnosis, we can treat it more aggressively because we know their cancer is likely to become invasive.


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Contact: Jamie Davis Kaun
jamie.davis@uc.edu
513-558-4625
University of Cincinnati
Source:Eurekalert

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