Navigation Links
Biomarker may be able to help predict risk of heart failure, cardiovascular death
Date:11/15/2010

Certain measures of the blood biomarker cardiac troponin T (cTnT), a cardiac-specific protein, using a highly sensitive test, are associated with the development of heart failure or cardiovascular death in older adults, according to a study that will appear in the December 8 issue of JAMA. The study is being released early online because it will be presented at the American Heart Association's annual meeting.

"Older adults comprise the majority of new-onset heart failure (HF) diagnoses, but traditional risk-factor prediction models have limited accuracy in this population to identify those at highest risk for hospitalization or death," according to background information in the article. Blood-based biomarkers, including troponins, have been advocated for use as supplemental to clinical risk factors to identify older adults at high risk for adverse cardiovascular outcomes, but studies examining the prognostic value of these markers have reported inconsistent results.

Prior studies have used standard troponin assays that are only able to detect circulating troponin levels in a small proportion of individuals. Recently, a highly sensitive cardiac troponin T assay has been developed, designed to improve accuracy. "This assay has detected circulating cTnT in almost all patients with chronic HF or ischemic heart disease and provides independent prognostic information with respect to HF admission and cardiovascular death in these patients," the authors write.

Christopher R. deFilippi, M.D., of the University of Maryland School of Medicine, Baltimore, and colleagues examined the ability to detect a measurable cTnT concentration in older adults using the highly sensitive cTnT assay and whether higher concentrations would be associated with a greater risk of new-onset HF and cardiovascular death. The researchers analyzed data from the Cardiovascular Health study and included 4,221 community-dwelling adults ages 65 years or older without prior HF who had cTnT measured using the highly sensitive assay at the beginning of the study (1989-1990) and repeated after 2 to 3 years (n = 2,918). Concentrations of cTnT were equal to or more than the limit of detection in 2,794 participants (66.2 percent).

During a median (midpoint) follow-up of 11.8 years from the initial cTnT measurement, 1,279 participants experienced new-onset HF and 1,103 cardiovascular deaths occurred, with a greater risk of both end points associated with higher cTnT concentrations. Also, the risks of HF and cardiovascular death were higher among those participants with detectable compared with undetectable levels at follow-up, irrespective of the baseline level.

Analysis indicated that for participants with measurable cTnT levels at the beginning of the study, an increase of more than 50 percent was associated with an increased risk of HF and a greater risk of cardiovascular death, adjusting for baseline cTnT and risk factors. In contrast, a decrease of more than 50 percent was associated with a risk-factor adjusted lower risk of HF and lower risk of cardiovascular death compared with those participants with 50 percent or less change.

For the prediction of both outcomes, the addition of baseline cTnT measurements to clinical risk factor models only modestly but statistically significantly improved classification.

"Detectable cTnT levels as measured by a highly sensitive assay were present in the majority of community-dwelling older adults in this cohort, and higher concentrationswithin a normal range established for a younger general populationreflect a greater burden of cardiovascular risk factors and imaging evidence of cardiac disease. Independent of these comorbidities, cTnT concentrations were associated with risk of new-onset HF and cardiovascular death. Furthermore, longitudinal changes in cTnT concentrations were common in this cohort and correspond with a dynamic change in risk levels over time," the authors conclude.


'/>"/>

Contact: Bill Seiler
bseiler@umm.edu
410-328-8919
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Haptoglobin as an early serum biomarker of virus-induced type 1 diabetes in rats
2. Radiation pharmacogenomics identifies biomarkers that could personalize cancer treatment
3. Mayo researchers find biomarkers for personalizing radiation cancer treatment
4. c-Met may be a biomarker for metastatic hepatocellular carcinoma
5. Novel biomarker may predict response to new VEGF receptor inhibitor
6. Biomarkers May Aid in Early Diagnosis of Alzheimers
7. The cancer biomarker conundrum: Too many false discoveries
8. Biomarkers Could Spot Alzheimers Disease Early, Studies Suggest
9. Hydrophobic proteins: Potential biomarkers for colorectal cancer
10. A prognostic and predictive biomarker for nonsmall cell lung cancer
11. Research identifies patterns of CD24, a novel biomarker for non-small cell lung carcinomas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2017)... ... July 25, 2017 , ... Dr. Donna Bergman, professor of ... and published an article in the medical science journal Physical Medicine and Rehabilitation ... article and the research that helped produce it, were written and conducted in ...
(Date:7/25/2017)... (PRWEB) , ... July 25, 2017 , ... ... Winner for its Product Innovation in the prestigious CEO World Awards®. The coveted ... performance, new products and services, CEO case studies, corporate social responsibility, and milestones ...
(Date:7/24/2017)... , ... July 24, 2017 , ... Cheerag D. ... Saint Luke’s Marion Bloch Neuroscience Institute (SLMBNI), part of Saint Luke’s Health ... 2016. , Cheerag D. Upadhyaya, MD. M.Sc., FAANS joins Stanley P. Fisher, ...
(Date:7/24/2017)... ... July 24, 2017 , ... Horizon Goodwill Industries, ... opportunity that helps high school girls succeed in STEM programs as well as ... Goodwill will host over 20 high school girls at their corporate headquarters on ...
(Date:7/24/2017)... , ... July 24, 2017 , ... Every year, thousands ... and educational conference, InstructureCon. Each annual event is coupled with a dynamic theme like ... a James Bond theme, Mission: InstructureCon 0017. , To extend their partnership with ...
Breaking Medicine News(10 mins):
(Date:7/6/2017)... , July 6, 2017 ThriveRx, the nutrition division of ... their families to thrive on nutrition support. To celebrate its ... new site has a fresh new look with improved organization to create ... ... ...
(Date:7/5/2017)... -- Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ... pharmaceutical company focused on the development of oral drug delivery ... Israel Securities Authority to dual-list its common stock on the ... trading on the TASE on July 12, 2017 under the ... Company, it is expected that Oramed will be included in ...
(Date:7/5/2017)... 2017   BioLife Solutions , Inc. (NASDAQ: ... of proprietary clinical grade cell and tissue hypothermic ... today announced that it has reached an agreement with ... shareholder, to modify its existing credit facility effective June ... WAVI agreed to exchange its existing $4.25 million credit ...
Breaking Medicine Technology: