Navigation Links
Biomarker identified in relation to drug response in refractory urothelial cancer
Date:3/31/2012

CHICAGO The antiangiogenic drug pazopanib has demonstrated clinically meaningful activity in patients with refractory urothelial cancer, according to results presented at the AACR Annual Meeting 2012, held here March 31 - April 4. The results also revealed that increases in interleukin-8 levels early after treatment with pazopanib may predict a lack of tumor response to the therapy.

"Historically, prognosis of patients with relapsed or refractory urothelial cancer is quite dismal," said Andrea Necchi, M.D., faculty member in the department of medicine at Fondazione IRCCS Istituto Nazionale dei Tumori in Milan, Italy. "Patients who fail to be cured after multiple chemotherapy regimens have a poor survival estimate, and palliative care is a reasonable trade-off."

Data from the phase II proof-of-concept trial identified pazopanib as the first targeted compound to have clinically meaningful activity in patients with refractory urothelial cancer, according to Necchi.

"Our data indicate that pazopanib seems to be a legitimate drug in this disease," said Necchi. "Most interestingly, our biomarker analysis clearly pointed out the role of rising levels of circulating interleukin-8 as an early and potentially practice-changing indicator of tumor resistance and poor survival."

The researchers assigned 41 patients with relapsing or progressing urothelial cancer between 2010 and 2011 to 800 mg once-daily pazopanib. All patients had at least one prior chemotherapy regimen for metastatic disease.

At follow-up, seven patients had a partial response to therapy and 24 patients had stable disease an overall clinical benefit of 76 percent. Median progression-free survival was 2.6 months, and median overall survival was 4.7 months. However, 10 percent of patients had a long-term cure after a median follow-up of 19 months.

The researchers examined blood samples for predictive biomarkers at baseline and every four weeks. The
'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Panel of serum biomarkers may reduce number of lung biopsies needed
2. Biomarkers identify acute kidney injury in emergency patients
3. Genetic sequencing could help match patients with biomarker-driven cancer trials, treatments
4. Metabolic syndrome biomarkers predict lung function impairment after exposure to WTC dust
5. Mass. General Cancer Center and Vall dHebron Institute of Oncology biomarker alliance
6. Neurologists identify potential biomarker of cognitive decline for earlier diagnosis of disease
7. Biomarker detects graft-versus-host-disease in cancer patients after bone marrow transplant
8. Drug safety, efficacy, and potential new cancer biomarker predicted by NextBio
9. FDA clears biomarker test for ovarian cancer
10. Traumatic brain injury: NIH-funded researchers will assess biomarkers for diagnosis and treatment
11. Fast ripples confirmed to be valuable biomarker of area responsible for seizure activity in children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... , ... August 30, 2015 , ... Rio Salado ... to serve as the college’s Vice President of Strategic Initiatives and Information Services. O’Shea, ... to help the college expand its reach and impact through innovative technologies and strategies. ...
(Date:8/29/2015)... ... August 29, 2015 , ... ... support and protection against dribbled urine and sweat. "In order to prevent these ... , The EASY ACCESS DRYNESS ENHANCED MEN'S UNDERGARMENT provides optimal support for a ...
(Date:8/29/2015)... Aliso Viejo, CA (PRWEB) , ... August 29, 2015 , ... ... Cut Pro X . Each preset contains 15 seconds of unique footage that users ... presets that rise, fall, zoom, attract and more. Users can customize color, brightness, scale, ...
(Date:8/28/2015)... ... ... Rio Salado College joined nine educational institutions in Washington D.C., July ... - Next Generation Learning Challenges 2015 Breakthrough Models Incubator funded by the Bill ... hosted by EDUCAUSE and NGLC, which is designed to bring leadership teams of ...
(Date:8/28/2015)... Los Angeles, CA (PRWEB) , ... August 28, 2015 , ... ... seemingly endless journey that local pizza maker Paul LaRocco has gone through to open ... the city approval and permitting process tends to take several months, but the current ...
Breaking Medicine News(10 mins):Health News:Rio Salado College Appoints New Vice President of Strategic Initiatives and Information Services 2Health News:Modified Men’s Underwear Promote More Comfort and Hygiene - Designed by InventHelp Client (LGI-1968) 2Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 3Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 4Health News:Article on Building Approval Process for LA Business Highlights the Need for a Bridge Between Businesses and City Officials, says Fire Protection Group Inc. 2
... (HealthDay News) -- Certain factors unique to professional sports can ... teams and their staff, a new report suggests. Norovirus ... as stomach flu) and causes 21 million cases of illness ... in the Oct. 31 online edition of the journal ...
... New research by the Institute for Health Metrics and ... innovative and improved methods for analyzing verbal autopsies ... countries without a complete vital registration system are ... countries struggling to understand disease trends., While many high-income ...
... control are vastly different from those used by earlier ... and with different means of delivery (not just a ... women,s pleasure remain. An Indiana University study ... things such as arousal, lubrication and orgasm, found that ...
... cognitive impairment is Fragile X Syndrome, caused by mutation or ... also the most common genetic cause of autism. Understanding how ... help Fragile X patients and others. Researchers from ... and colleagues from Brown University, have identified the FMRP protein ...
... --,A physically active lifestyle may help protect your eyes from ... cause of blindness, typically develops when fluid pressure inside the ... study, researchers looked at the association between physical activity and ... 90 in Britain. The participants were evaluated between 1993 and ...
... , SATURDAY, Oct. 29 (HealthDay News) -- Practice ... skill, but to become truly great other qualities must come ... researchers who studied how practice affects the success of chess ... issue of Current Directions in Psychological Science , the ...
Cached Medicine News:Health News:Stomach Bug Easily Passed Among Pro Sports Teams: Report 2Health News:IHME develops fast, affordable ways for countries to better identify causes of death in populations 2Health News:IHME develops fast, affordable ways for countries to better identify causes of death in populations 3Health News:IHME develops fast, affordable ways for countries to better identify causes of death in populations 4Health News:Not your mother's birth control, same troubles 2Health News:Linking Fragile X Syndrome proteins and RNA editing mistakes at nerve-muscle junction 2Health News:Linking Fragile X Syndrome proteins and RNA editing mistakes at nerve-muscle junction 3Health News:Glaucoma Experts Eye Benefits of Exercise 2Health News:Practice Doesn't Always Make Perfect, Study Suggests 2
(Date:8/29/2015)... LONDRES, August 29, 2015 ... para los sistemas de imagen por Ultrasonidos   ... tiempos de examen rápidos y un flujo de trabajo ... diagnóstica en el proceso de detección de Cardiopatías   ... ha anunciado hoy el lanzamiento europeo de HeartModel ...
(Date:8/28/2015)... India , August 28, 2015 ... Biomarker Market by Tumor (Breast, Lung, Prostate) Type (Protein ... Application (Diagnostic, Drug Discovery, Prognostic) & Geography - Global ... Market is expected to reach around 17,689.0 Million USD ... forecast period of 2015 to 2020. ...
(Date:8/28/2015)... Research and Markets ( http://www.researchandmarkets.com/research/jq34zf/investigation ) ... on China,s Tobramycin Market, 2010-2019" report to their ... eye drop and ointment are the most common prescription ... caused by eye infection. Currently, dozens of enterprises in ... tobramycin, among which the Top 5 are s.a. Alcon- ...
Breaking Medicine Technology:Philips presenta HeartModel A.I en el Congreso ESC 2015 2Philips presenta HeartModel A.I en el Congreso ESC 2015 3Philips presenta HeartModel A.I en el Congreso ESC 2015 4Philips presenta HeartModel A.I en el Congreso ESC 2015 5Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 2Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 3Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 4Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 5Investigation Report on China's Tobramycin Market, 2015-2019 2
... Echo Therapeutics,(OTC Bulletin Board: ECTE) today announced ... of its Symphony Transdermal Continuous Glucose,Monitoring (tCGM) ... and Technology.,The article highlights that each of ... supporting the use of Echo,s Symphony(TM) tCGM,System ...
... SAN FRANCISCO, July 11 Nile Therapeutics,Inc. (Nasdaq: ... dosed the first acute,setting heart failure patient in ... of the company,s lead product candidate,CD-NP, a novel ... acute decompensated heart failure., The primary objective ...
Cached Medicine Technology:Echo Therapeutics Announces Publication of Positive Clinical Data for its Symphony Transdermal Continuous Glucose Monitoring System in Journal of Diabetes Science and Technology 2Echo Therapeutics Announces Publication of Positive Clinical Data for its Symphony Transdermal Continuous Glucose Monitoring System in Journal of Diabetes Science and Technology 3Echo Therapeutics Announces Publication of Positive Clinical Data for its Symphony Transdermal Continuous Glucose Monitoring System in Journal of Diabetes Science and Technology 4Nile Therapeutics Announces Dosing in Phase IIa Study of CD-NP in Heart Failure Patients 2Nile Therapeutics Announces Dosing in Phase IIa Study of CD-NP in Heart Failure Patients 3
... tool designed for ophthalmic surgeons. ... reliable, safe and easy to ... (one year for ultrasonic handpiece). ... console, phaco handpiece, foot pedal, ...
Non-sterile oncoseed seeds consists of a welded titanium capsule containing....
... 62 mirrors allow complete ... with little lens rotation. ... convenient for eyes with ... holding ring available in ...
Direct gonioscopy lens with magnification. The lens rests on the scleral flange creating a corneal vault and leaving the anterior chamber angle undisturbed. Three sizes available....
Medicine Products: