Navigation Links
Biomarker identified in relation to drug response in refractory urothelial cancer
Date:3/31/2012

CHICAGO The antiangiogenic drug pazopanib has demonstrated clinically meaningful activity in patients with refractory urothelial cancer, according to results presented at the AACR Annual Meeting 2012, held here March 31 - April 4. The results also revealed that increases in interleukin-8 levels early after treatment with pazopanib may predict a lack of tumor response to the therapy.

"Historically, prognosis of patients with relapsed or refractory urothelial cancer is quite dismal," said Andrea Necchi, M.D., faculty member in the department of medicine at Fondazione IRCCS Istituto Nazionale dei Tumori in Milan, Italy. "Patients who fail to be cured after multiple chemotherapy regimens have a poor survival estimate, and palliative care is a reasonable trade-off."

Data from the phase II proof-of-concept trial identified pazopanib as the first targeted compound to have clinically meaningful activity in patients with refractory urothelial cancer, according to Necchi.

"Our data indicate that pazopanib seems to be a legitimate drug in this disease," said Necchi. "Most interestingly, our biomarker analysis clearly pointed out the role of rising levels of circulating interleukin-8 as an early and potentially practice-changing indicator of tumor resistance and poor survival."

The researchers assigned 41 patients with relapsing or progressing urothelial cancer between 2010 and 2011 to 800 mg once-daily pazopanib. All patients had at least one prior chemotherapy regimen for metastatic disease.

At follow-up, seven patients had a partial response to therapy and 24 patients had stable disease an overall clinical benefit of 76 percent. Median progression-free survival was 2.6 months, and median overall survival was 4.7 months. However, 10 percent of patients had a long-term cure after a median follow-up of 19 months.

The researchers examined blood samples for predictive biomarkers at baseline and every four weeks. The
'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Panel of serum biomarkers may reduce number of lung biopsies needed
2. Biomarkers identify acute kidney injury in emergency patients
3. Genetic sequencing could help match patients with biomarker-driven cancer trials, treatments
4. Metabolic syndrome biomarkers predict lung function impairment after exposure to WTC dust
5. Mass. General Cancer Center and Vall dHebron Institute of Oncology biomarker alliance
6. Neurologists identify potential biomarker of cognitive decline for earlier diagnosis of disease
7. Biomarker detects graft-versus-host-disease in cancer patients after bone marrow transplant
8. Drug safety, efficacy, and potential new cancer biomarker predicted by NextBio
9. FDA clears biomarker test for ovarian cancer
10. Traumatic brain injury: NIH-funded researchers will assess biomarkers for diagnosis and treatment
11. Fast ripples confirmed to be valuable biomarker of area responsible for seizure activity in children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... a leader in the wig industry, has announced a great ... promotion features: , > 400 pieces of FOUR ... (no coupon code needed), > 10% off for ... $49 , Visit http://www.uniwigs.com for more details , The ... 1st and the first 100 shoppers each day will receive our ...
(Date:11/28/2014)... Patten Pecans, based in Lakeland, Georgia, ... passions driving them, they've added a pecan oil to ... pecans oils, they've found this pecan oil from ... flavorful, retaining the buttery pecan notes that are in ... found in pecans nuts is found in pecan ...
(Date:11/28/2014)... An inventor from Flint, Mich., wants to minimize ... this idea while lying in a hospital bed, unable to ... The Bed Buddy provides a more ergonomic and convenient way ... eliminates the need to leave the bed, which avoids hassle ... to use and producible in design variations, it's ideal for ...
(Date:11/28/2014)... 28, 2014 Before that Thanksgiving meal even ... for the Christmas shopping season. Today, people will stand in ... Friday, the biggest retail shopping day of the year. ... device, New Albany dentist Dr. Ronald Receveur is ... oral health and literally brighten a few smiles. , The ...
(Date:11/28/2014)... talklocal ( http://www.talklocal.com ) is launching in Denver, ... phone in about 90 seconds. , The launch comes ... to have touched down just north of the city on ... Denver residents now know all too well the value of ... local pros in over 50 service categories on speed dial ...
Breaking Medicine News(10 mins):Health News:Pre-X'mas Crazy Sale Starts from $0 at UniWigs.com 2Health News:Patten Pecans Goes Local with Nutritious Georgia Pecan Oil 2Health News:New Albany Dentist Offers Gift Ideas That Can Improve Oral Health 2Health News:New Albany Dentist Offers Gift Ideas That Can Improve Oral Health 3Health News:New Albany Dentist Offers Gift Ideas That Can Improve Oral Health 4Health News:TalkLocal Launches In Denver A Week After Multiple Tornadoes Hit Near City 2
... water in cold winter air tied to more influenza, study ... snow may seem like perfect incubators for the flu, but ... might be responsible for increases in influenza, such as those ... suggested that humidity is connected to seasonal epidemics of flu, ...
... , ... ... ... ...
... ... participate in a Buenos Aires Health Fair while learning Spanish. This program will enable ... environment while providing much-needed medical services to local residents. , ... (PRWEB) February 23, 2010 -- ECELA Spanish ...
... ... M2M, or Machine-to-Machine, refers to the communications between ... historic impediments to M2M solution deployment: system complexity and up-front costs. ... reduces the cost and time to build and deploy these applications. ...
... ... Last 2 Quarters Of 2009 , ... Pittsburgh, PA (PRWEB) February 23, 2010 -- Oncology Med, Inc. (Pink ... it expanded the number of contracts for its mobile turnkey brachytherapy programs by 300% ...
... ... everyone will carry their snacks while on the go. KUBBE is the first and ... hassle free. , ... 17, 2010 -- KUBBE is a trendy plastic utility buckle that allows people to carry ...
Cached Medicine News:Health News:Dry Weather Boosts Odds of Flu Outbreaks 2Health News:Cristophe Salon in Beverly Hills Teams Up with 'Mad Men' Actor to Help Raise Money for His 17-Year-Old Cousin's Heart Transplant 2Health News:Cristophe Salon in Beverly Hills Teams Up with 'Mad Men' Actor to Help Raise Money for His 17-Year-Old Cousin's Heart Transplant 3Health News:Cristophe Salon in Beverly Hills Teams Up with 'Mad Men' Actor to Help Raise Money for His 17-Year-Old Cousin's Heart Transplant 4Health News:ECELA Spanish School in Argentina Offers Students Opportunity to Work in Buenos Aires Free Health Fair 2Health News:ECELA Spanish School in Argentina Offers Students Opportunity to Work in Buenos Aires Free Health Fair 3Health News:Cloud Computing Platforms Address Unique M2M Application Needs, According To New SensorLogic White Paper 2Health News:Demand For Mobile Prostate Cancer Brachytherapy Vendor Programs Continues Into 2010 2Health News:Demand For Mobile Prostate Cancer Brachytherapy Vendor Programs Continues Into 2010 3Health News:Demand For Mobile Prostate Cancer Brachytherapy Vendor Programs Continues Into 2010 4Health News:Demand For Mobile Prostate Cancer Brachytherapy Vendor Programs Continues Into 2010 5
(Date:11/26/2014)... YORK and LONDON , ... of market intelligence, MarketResearch.com is pleased to announce the ... and Consultancy focusing on the active pharmaceutical ingredient (API) ... visit: http://www.marketresearch.com/land/publisher.asp?vendorid=4023&progid=86891 . In IQ4I,s ... – Forecast to 2020 , IQ4I ...
(Date:11/26/2014)...  At the American Dental Association,s Annual Meeting in ... Kerr Group was honored to be part of the ... to see and test the Best of Class winners ... on the latest developments in dental technology. This year, ... CariVu Caries Detection Device and Kerr Demi ™  ...
(Date:11/26/2014)... , Nov. 25, 2014 Reinforcing its ... Philips (NYSE: PHG AEX: PHIA) ... Drug Administration (FDA) for its IQon Spectral CT ... This first-of-its kind technology adds a new dimension to ... the ability to characterize structures based on their material ...
Breaking Medicine Technology:MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 2MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 3KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 2KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 3Philips receives FDA 510(k) clearance for IQon Spectral CT 2Philips receives FDA 510(k) clearance for IQon Spectral CT 3
... testing system from Del Mar Reynolds Medical. ... or bicycle ergometer, PC, Cart, isolation transformer ... the same CardioDirect patient interface module that ... ,The system is also available using the ...
... ExTOL systems feature your choice of ... electrocardiographs, an easy-to-operate monitor and the ... exercise stress testing systems also feature ... point, pre-programmed or custom protocols, and ...
The Urchin heart positioner provides excellent access to target coronaries while minimizing hemodynamic instability...
Part of the Octopus System which includes both the Starfish & Octopus3. The Starfish Heart Positioner simplifies cardiac positioning and minimizes the associated hemodynamic deterioration when compa...
Medicine Products: