Navigation Links
Biomarker discovery may lead to reliable blood test for ectopic pregnancy
Date:2/17/2011

which could be used to signal the presence of a particular clinical disorder or disease.

"Most biomarkers being used clinically today were first discovered by focused studies of proteins known to be associated with a disease, such as the prostate-specific antigen, PSA, test for prostate cancer," Speicher explained. "Proteomics is unbiased in the sense that we are not trying to confirm the presence of a known protein, we simply compare the entire protein profile of people in a particular clinical condition or disease state to the protein profile of people in a healthy state."

"Instead of a single biomarker, we can define a panel of such markers, creating a test that weighs the relative importance of individual proteins," Speicher said. "It makes for more sensitive, reliable tests."

In the present study, the Speicher laboratory compared the proteomic signature of blood samples taken from known cases of ectopic pregnancy with blood samples taken from women who experienced a normal pregnancy. They discovered about 70 candidate biomarkers that could signal ectopic pregnancy, which stringent statistical analysis whittled down to the 12 most promising biomarkers. While some of the proteins had previously known associations with ectopic pregnancies, the researchers found at least two, including ADAM12, which had never been previously associated with ectopic pregnancy.

Speicher and his team worked in collaboration with Kurt T. Barnhart, M.D., a professor of obstetrics and gynecology at the University of Pennsylvania School of Medicine. In a study recently published online by the journal Fertility and Sterility, Barnhart, Speicher and colleagues at Penn and two other urban academic medical centers reported on elevated ADAM12 levels in women seen in emergency rooms for bleeding resulting from an undiagnosed ectopic pregnancy.

The next step is to further confirm and validate the usefulness of their panel of biomarkers using additiona
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
2. Personalizing cancer: Creating biomarkers from tumor DNA
3. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
4. Reliable biomarkers needed for early detection of liver cancer
5. More Reliable Biomarkers Needed for Early Detection of Liver Cancer
6. UAB researchers find 4 biomarkers important in colerectal cancer treatment prognosis
7. BATTLE links potential biomarkers to drugs for lung cancer
8. UAB researchers find 4 biomarkers important in colorectal cancer treatment prognosis
9. Research identifies patterns of CD24, a novel biomarker for non-small cell lung carcinomas
10. A prognostic and predictive biomarker for nonsmall cell lung cancer
11. Hydrophobic proteins: Potential biomarkers for colorectal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Top 10 Best SEO Hosting ... and announced Bluehost ( http://www.bluehost.com/track/seohosts ), MaxCDN, and ... provide high quality PHP hosting at affordable rates. ... SEO Hosting are unbiased and entirely independent, ensuring ... possible. During the recent years, web hosting industry ...
(Date:8/20/2014)... Skmen.com, the popular online supplier of men’s ... mini party dresses online. Along with this, the company ... Now, all the fresh products are offered with great discounts ... this special offer before August 31. , Skmen.com has ... sale. A large proportion of its clothes are selling well ...
(Date:8/20/2014)... August 21, 2014 Medical Alert Systems, ... and reviews of some of the most popular medical ... pleased to announce that it is now offering special ... seniors who are on a fixed income but would ... announcement comes as very welcome news. , As a ...
(Date:8/20/2014)... is one of the most experienced special occasion dress ... trust of thousands of consumers. It is popular for ... unveiled its new designs of beautiful summer cocktail ... offers more than 20 different kinds of high quality ... promotional prices (up to 60 percent off). Also, it ...
(Date:8/20/2014)... Top10BestSEOHosting.com is a website dedicated ... products. It is headed by a team of ... offers research-based information and factual studies about the ... current market. , Recently, Top10BestSEOHosting.com has compared ... GoDaddy and Bluehost are the most recommended ...
Breaking Medicine News(10 mins):Health News:New Reviews Of Cheap PHP Hosting Companies Unveiled By Top 10 Best SEO Hosting 2Health News:Skmen.com: New Designs Of Mini Party Dresses Provided Online 2Health News:Medical Alert Systems Website Now Offering Special Prices on the Popular Medical Guardian Product 2Health News:Medical Alert Systems Website Now Offering Special Prices on the Popular Medical Guardian Product 3Health News:Angeldress.co.uk Now Dazzles With Beautiful Summer Cocktail Party Dresses 2Health News:New Reviews For Linux Web Hosting Suppliers Announced By Top10BestSEOHosting.com 2
... & Science University Cancer Institute researchers have found that ... Gleevec-resistant chronic myeloid leukemia (CML). The results of their ... in the Proceedings of the National Academy of Sciences. ... Institute Director Brian Druker, M.D., is the current first ...
... 24 Under contract with the,Air Force ... ECC is,providing design-build services for a state-of-the-art ... The 51,000-square-foot fitness center integrates contemporary,technologies, modern ... include three NCAA-sized basketball courts, three,volleyball courts, ...
... to one-half of new cancer treatments that reach assessment ... successful, according to a report in the March 24 ... JAMA/Archives journals. , Cancer remains the second leading cause ... have been made in survival and other outcomes, according ...
... deaths in the United States increased by 123 percent ... which data are available. Mortality rates peaked in 2002, ... people 55 to 64 years old. These findings appear ... the American Association for the Study of Liver Diseases ...
... (OTCBB:DSCI), provider of advanced wound care products, announced,today ... year-end 2007 results on,April 1, 2008. The Company ... to,discuss the results at 11:00 am EDT. Interested ... passcode,77274977 to access the call. You may also ...
... Education Lecture Series for Healthcare ... ... common and most malignant type of glioma. Healthcare professionals,face many challenges ... length of survival in patients is less than,one year., Recent ...
Cached Medicine News:Health News:OHSU Cancer Institute researchers identify new approach to help control drug resistance in leukemia 2Health News:ECC Builds Innovative, Green Fitness Center at Vandenberg Air Force Base (AFB) 2Health News:Cancer treatments in phase 3 trials successful up to half of the time 2Health News:Study: Dramatic rise in hepatitis C-related deaths in the United States 2Health News:Derma Sciences to Report 2007 Fourth Quarter and Year-End Results on April 1, 2008 2Health News:Adult Glioblastoma: Strategies, Challenges, and Opportunities 2
(Date:8/20/2014)... PLAINFIELD, N.J. , Aug. 20, 2014 PTC Therapeutics, ... will participate at two upcoming investor conferences: - ... Seasons Hotel in Boston on Wednesday, ... Biotech Conference at The Mandarin Oriental Boston on Thursday, September ... present a company update at the Bank of America Merrill ...
(Date:8/20/2014)... YORK , Aug. 20, 2014 ... is available in its catalogue: The ... IVD Industry http://www.reportlinker.com/p01618927/The-Impact-of-Healthcare-Reform-PPACA-On-the-US-IVD-Industry.html ... Act" (H.R. 3590) is complex legislation that affects ... of its provisions are beginning to take effect ...
(Date:8/20/2014)... 20, 2014 Reportlinker.com announces that ... in its catalogue: Personal Accident ... and Opportunities to 2017 ... The report provides in depth market analysis, ... accident and health insurance segment, including: • ...
Breaking Medicine Technology:PTC Therapeutics to Participate at Upcoming Investor Conferences 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 3The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 4The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 5The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 6Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 2Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 3Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 4Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 5Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 6Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 7Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 8Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 9Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 10Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 11Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 12Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 13Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 14Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 15Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 16Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 17Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 18Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 19Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 20Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 21Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 22Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 23
... REDWOOD CITY, Calif., March 19, 2012 Ingenuity Systems, ... life science researchers, today announced that the Weill Cornell ... iReport for use in its sequencing core facility.  Variant ... the output of whole genome and exome sequencing experiments ...
... 19, 2012  Johnson & Johnson (NYSE: JNJ) will provide ... parties on Monday, March 26th at approximately 10:30 ... College of Cardiology (ACC) Annual Scientific Sessions in ... of the EINSTEIN-PE study in treating patients with ...
Cached Medicine Technology:Weill Cornell Medical College Selects Ingenuity® Variant Analysis™ and Ingenuity® iReport™ for Sequencing Core Facility 2
Adjustable Velcro© closures at crown and behind the neck distinguish this immediate post-op face and chin garment for maximum support and compression....
A CDI original design with seams on the outside, away from the skin, adjustable fit and removable/adjustable back strap, provides patient comfort and needed compression....
Ideal for autoplasty and liposuction of chin and cheeks...
Applies pressure on scalp to stretch it before surgery...
Medicine Products: