Navigation Links
Biomarker discovery may lead to reliable blood test for ectopic pregnancy
Date:2/17/2011

which could be used to signal the presence of a particular clinical disorder or disease.

"Most biomarkers being used clinically today were first discovered by focused studies of proteins known to be associated with a disease, such as the prostate-specific antigen, PSA, test for prostate cancer," Speicher explained. "Proteomics is unbiased in the sense that we are not trying to confirm the presence of a known protein, we simply compare the entire protein profile of people in a particular clinical condition or disease state to the protein profile of people in a healthy state."

"Instead of a single biomarker, we can define a panel of such markers, creating a test that weighs the relative importance of individual proteins," Speicher said. "It makes for more sensitive, reliable tests."

In the present study, the Speicher laboratory compared the proteomic signature of blood samples taken from known cases of ectopic pregnancy with blood samples taken from women who experienced a normal pregnancy. They discovered about 70 candidate biomarkers that could signal ectopic pregnancy, which stringent statistical analysis whittled down to the 12 most promising biomarkers. While some of the proteins had previously known associations with ectopic pregnancies, the researchers found at least two, including ADAM12, which had never been previously associated with ectopic pregnancy.

Speicher and his team worked in collaboration with Kurt T. Barnhart, M.D., a professor of obstetrics and gynecology at the University of Pennsylvania School of Medicine. In a study recently published online by the journal Fertility and Sterility, Barnhart, Speicher and colleagues at Penn and two other urban academic medical centers reported on elevated ADAM12 levels in women seen in emergency rooms for bleeding resulting from an undiagnosed ectopic pregnancy.

The next step is to further confirm and validate the usefulness of their panel of biomarkers using additiona
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
2. Personalizing cancer: Creating biomarkers from tumor DNA
3. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
4. Reliable biomarkers needed for early detection of liver cancer
5. More Reliable Biomarkers Needed for Early Detection of Liver Cancer
6. UAB researchers find 4 biomarkers important in colerectal cancer treatment prognosis
7. BATTLE links potential biomarkers to drugs for lung cancer
8. UAB researchers find 4 biomarkers important in colorectal cancer treatment prognosis
9. Research identifies patterns of CD24, a novel biomarker for non-small cell lung carcinomas
10. A prognostic and predictive biomarker for nonsmall cell lung cancer
11. Hydrophobic proteins: Potential biomarkers for colorectal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... Adeptia, a leading provider of innovative ... it is the featured company in an impact report ... report, “Adeptia Bets on Converged Cloud Integration and Process-Orchestration ... strategy, products, pricing, customers and competition. , ... for integration and process orchestration, especially when price, ease ...
(Date:5/21/2013)... May 21 (HealthDay News) -- Urban elementary school ... experience sleep problems and suffer academically, new research ... aged seven to nine, we found that compromised ... and impaired academic performance," said study author ... human behavior at Brown University,s Alpert Medical School ...
(Date:5/21/2013)... 21 (HealthDay News) -- The monstrous tornado that ... adults and children, is a stunning example of ... well-being. But even thunderstorms with lightning and ... experts note. Some anxiety in the ... children develop storm phobias that interfere with their ...
(Date:5/21/2013)... Philosophical Society (APS) has awarded New York University neuroscientist ... in recognition of his "pioneering work on the neuroscience ... University,s Center for Neural Science, is the second NYU ... yearsJoseph LeDoux received the honor in 2011 in recognition ... emotional learning, particularly fear learning, and fear memory." ...
(Date:5/21/2013)... 2013 Residents in St. Petersburg, FL ... now that Dr. David Sherberg, DMD, has joined Coast ... Dr. Sherberg provides preventive, restorative and cosmetic dentistry to ... friendly team provide a wide variety of services ... canal therapy, crowns, bridges, dentures, dental implant restorations, veneers, ...
Breaking Medicine News(10 mins):Health News:Adeptia Featured in Recent 451 Research Impact Report 2Health News:Sleepless Nights May Hurt School Performance of Kids With Asthma 2Health News:Weather Worries Can Threaten a Child's Mental Health 2Health News:NYU's Movshon receives Lashley Award for his research on the neuroscience of vision 2Health News:Coast Dental Pasadena Welcomes Dr. David Sherberg 2Health News:Coast Dental Pasadena Welcomes Dr. David Sherberg 3
... - Telephone outreach can dramatically increase the incidence of ... population, constituting predominantly of black men and women. ... not believe in getting regular CRC screening done. ... day stool blood test, reduces mortality by as much ...
... could reduce 50% of the HIV infection rate among heterosexual ... Ugandan men seeking it.// , ,2,500 Ugandan ... of which nearly half were adults. Less than 400 adult ... Health found that new HIV infections among circumcised heterosexual men ...
... University of Vermont have uncovered the possible causes for ... Their findings were// published November 1, 2006 in the ... is responsible for signaling regional blood flow changes in ... receive an uninterrupted supply of oxygen and glucose, which ...
... "picture-to-speech" project in Singapore is using a customised ... lives of the intellectually disabled,// innovators said Thursday. ... the handheld innovation helps those with speech impairments ... ordering food or asking for medical attention from ...
... chronic hepatitis C are at risk of suffering from ... two weeks from commencement of treatment, says the researchers in ... Visual Science (IOVS)in the January 2007 issue. ,Researchers ... changes in diameter of blood vessels and the velocity ...
... will now have to prescribe medicines by their generic names ... Singh. ,"We have issued a letter in this regard ... health centres and dispensaries," Singh told IANS. ... salt, and not the brand names. Failure to do so ...
Cached Medicine News:Health News:Telephone Outreach Boost CRC Screening In Urban Minority 2Health News:Potential Key to Brain Blood-Flow Disorders Explored by Scientists 2Health News:Potential Key to Brain Blood-Flow Disorders Explored by Scientists 3Health News:Potential Key to Brain Blood-Flow Disorders Explored by Scientists 4
(Date:5/21/2013)... May 21, 2013 Kepner-Tregoe (KT), the ... that 13-year veteran Chris Geraghty ... experience includes more than 20 years serving the ... manufacturing organizations. He succeeds Ray Baxter ... Kepner-Tregoe,s Chairman of the Board and CEO. ...
(Date:5/21/2013)... , May 21, 2013  IsoRay, Inc. (AMEX: ... it has entered into an exclusive international distribution agreement ... product line in Greece . IsoRay ... brachytherapy and medical radioisotope applications for brain cancer, lung ... ("gyn") cancer. IASIS Medical is ideally ...
(Date:5/21/2013)... , May 21, 2013  Vasomedical, Inc. (OTC BB: VASO) ... design, manufacture and sale of medical devices and in the ... Jun Ma , President and CEO of ... MicroCap Conference on Thursday, May 30, 2013 in ... The Company,s presentation is scheduled to begin ...
Breaking Medicine Technology:Kepner-Tregoe, Inc. Promotes Chris Geraghty to Chief Executive Officer 2Kepner-Tregoe, Inc. Promotes Chris Geraghty to Chief Executive Officer 3IsoRay Announces A New International Distributor For Greece 2IsoRay Announces A New International Distributor For Greece 3Vasomedical, Inc. To Present At The Second Annual Marcum LLP MicroCap Conference 2
... N.Y., Sept. 9 Misonix, Inc. (Nasdaq: ... the art, ultrasonic medical device technology, which worldwide ... into a new, three year, exclusive distribution agreement ... will sell and distribute the SonaStar® Ultrasonic Surgical ...
... video detailing has made a strong comeback after ... and healthcare market research company Manhattan Research,s ... detailing has more than doubled in the past two years, ... self-report that their prescribing behavior is influenced by these programs, ...
Cached Medicine Technology:Misonix Announces New Distribution Agreement For Spain 2Misonix Announces New Distribution Agreement For Spain 3New Study: Physician Adoption of Live Video Detailing Has Doubled Since 2008, But Will Likely Plateau Until 2012 as Pharma Optimizes Targeting 2New Study: Physician Adoption of Live Video Detailing Has Doubled Since 2008, But Will Likely Plateau Until 2012 as Pharma Optimizes Targeting 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: