Navigation Links
Biomarker detects graft-versus-host-disease in cancer patients after bone marrow transplant
Date:10/21/2011

A University of Michigan Health System-led team of researchers has found a biomarker they believe can help rapidly identify one of the most serious complications in patients with leukemia, lymphoma and other blood disorders who have received a transplant of new, blood-forming cells.

Known as a hematopoietic stem cell transplant, these patients receive bone marrow or peripheral blood stem cells from a matched donor who is either a family member or an unrelated volunteer.

The most common fatal complication of this type of transplant is graft-versus-host disease (GVHD), where the newly transplanted immune system of the donor attacks the patient's skin and internal organs. Up to 30 percent of recipients develop GVHD in their gastrointestinal tract, which is the organ most resistant to treatment.

Without invasive tests such as biopsies, however, GVHD can be difficult to distinguish from other causes of gastrointestinal distress, such as infection or side effects from medication.

The U-M team tested blood samples from over 1,000 patients who were treated in Ann Arbor, Germany and Japan.

"We believe we've found a reliable biomarker in the patients' blood that is specific to graft-versus-host disease and therefore can help us to rapidly identify patients for whom standard treatment is likely to be insufficient," says James L.M. Ferrara, M.D., co-lead author of the study and director of the U-M Combined Blood and Marrow Transplant Program. "This marker can also tell us whether a patient is likely to respond to therapy and may lead to an entirely new risk assessment for the disease. The findings were recently published online ahead of print publication in the journal Blood.

The marker, known as regenerating islet-derived 3-alpha (REG3-alpha), doesn't prevent patients from still needing a biopsy, Ferrara cautions, but taken with other predictive indicators, it could help doctors to ensure patients get the most a
'/>"/>

Contact: Ian Demsky
idemsky@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
2. Personalizing cancer: Creating biomarkers from tumor DNA
3. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
4. Reliable biomarkers needed for early detection of liver cancer
5. More Reliable Biomarkers Needed for Early Detection of Liver Cancer
6. UAB researchers find 4 biomarkers important in colerectal cancer treatment prognosis
7. BATTLE links potential biomarkers to drugs for lung cancer
8. UAB researchers find 4 biomarkers important in colorectal cancer treatment prognosis
9. Research identifies patterns of CD24, a novel biomarker for non-small cell lung carcinomas
10. A prognostic and predictive biomarker for nonsmall cell lung cancer
11. Hydrophobic proteins: Potential biomarkers for colorectal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... (PRWEB) October 20, 2014 Punzoné , ... in the U.S., has a lot to celebrate this month. ... country recognizes the achievements and contributions of Americans of Italian ... for Punzoné, and today it shares its favorite Italian cocktails ... trip to Italy - even if it is only in ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 Hastings and ... 30 years of service throughout the greater Phoenix area ... legal representation with regard to catastrophic automobile accidents. Statistics ... the country and throughout Arizona. As such, Hastings and ... for legal representation for those who have been injured ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 Dr. Babatunde ... Fund, welcomes news of a ceasefire agreement that is ... than 200 girls who were kidnapped from the north-eastern ... languished in captivity long enough, and it is high ... communities," stated Dr. Osotimehin. , "We owe it to ...
(Date:10/19/2014)... Recently, Top10BestSEOHosting.com has unveiled its newest ... and HostMonster are the best VPS hosting suppliers ... is the method of partitioning a physical server ... the appearance and capabilities of running on someone’s ... pays close attention to VPS products and related ...
(Date:10/19/2014)... Visual Impact Frequency Training - a ... to the public generating a frenzied buzz of ... community. The commotion surrounding the program's launch has ... an investigative review. , "Many gym-goers are familiar ... known as a training 'plateau' where they are ...
Breaking Medicine News(10 mins):Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 3Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 4Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 2Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 3Health News:The Best VPS Hosting Suppliers In The Market Unveiled By Top10BestSEOHosting.com 2Health News:Visual Impact Frequency Training Review: Rusty Moore's Latest Fitness Guide Released 2
... at the Stanford University School of Medicine have used ... patterns in children with poor reading skills and a ... with a typical IQ. The work provides more definitive ... regardless of their general cognitive ability. Schools and ...
... allow the blind to "see" with their hands, bodies ... a $2 million award from the National Science Foundation ... York and Georgia Institute of Technology (Georgia Tech). ... and Innovation" program, will fund a multidisciplinary team investigating ...
... 28 (HealthDay News) -- Adolescents with large social networks of ... than teens who play a less central role in their ... findings from the study of 2,610 U.S. students in grades ... teen,s social network may help delay the start of drinking. ...
... cases at the University of California, San Francisco (UCSF) Medical ... that occurs as healthy brain cells begin to form tumors. ... oligodendroglioma, a common type of brain tumor, at its earliest ... identified will have to prove safe and effective in clinical ...
... 28 (HealthDay News) -- About one in six asthma ... poor response to commonly prescribed inhaled asthma medications called ... that people with asthma carrying two copies of a ... not to respond to inhaled steroids as those without ...
... HIV prevention trial evaluating two antiretroviral (ARV)-based approaches for preventing ... of one of two different ARV tablets or of a ... tablets from the study. The decision to discontinue use of ... study data concluded that the trial will not be able ...
Cached Medicine News:Health News:Stanford brain imaging study shows physiological basis of dyslexia 2Health News:Stanford brain imaging study shows physiological basis of dyslexia 3Health News:City College of New York-led research could lead to wearable sensors for the blind 2Health News:City College of New York-led research could lead to wearable sensors for the blind 3Health News:How normal cells become brain cancers 2Health News:Gene Variant Linked to Failure of Asthma Drug 2Health News:Major HIV prevention trial in women to drop oral tenofovir arm 2Health News:Major HIV prevention trial in women to drop oral tenofovir arm 3Health News:Major HIV prevention trial in women to drop oral tenofovir arm 4Health News:Major HIV prevention trial in women to drop oral tenofovir arm 5
(Date:10/17/2014)... , Oct. 17, 2014 With the ... Affairs function has come across several challenges in ... and managing globalization.  The ... is dedicated to providing benchmarking and best practices ... Consortium is a service composed of three stages: ...
(Date:10/17/2014)... UBM Medica US announces that Neurology ... information resource for neurologists and other healthcare providers, features special ... , with discussions of the latest developments in approaches to ... Parkinson disease , more than the total of those who ... disease. Diagnosis can be difficult because there are no confirmatory ...
(Date:10/17/2014)... 17, 2014 ... ) has announced the addition of ... American Automated External Defibrillators (AED) Market" ... http://photos.prnewswire.com/prnh/20130307/600769) ,The report North American Automated ... market of devices based upon following ...
Breaking Medicine Technology:Early Key Findings from the Medical Affairs Consortium Research 2Neurology Times Features Coverage of Parkinson and Alzheimer Disease 2Neurology Times Features Coverage of Parkinson and Alzheimer Disease 3Micro Market Monitor : North American Automated External Defibrillators (AED) Market 2
... CHICAGO , June 2 The Female Health Company (Nasdaq: ... Condoms to be distributed for HIV/AIDS prevention to attendees at the 2010 World Cup. ... from June 11, 2010 to July 11, 2010 . , ... The month-long 2010 World Cup, which offers three million ...
... HAMILTON, N.J. , June 2 MedAvante, Inc., the leader in ... its CQC Continuous Quality Control Service for trials assessing Alzheimer,s Disease. Its CQC ... including depression, anxiety and schizophrenia in the United States , Europe ... , , , ...
Cached Medicine Technology:The Female Health Company Receives Order for 3.5 Million FC2 Female Condoms for Distribution at 2010 World Cup 2The Female Health Company Receives Order for 3.5 Million FC2 Female Condoms for Distribution at 2010 World Cup 3MedAvante Launches Service to Boost Reliability of Assessments to Reduce Risk of Failed Alzheimer's Disease Trials 2MedAvante Launches Service to Boost Reliability of Assessments to Reduce Risk of Failed Alzheimer's Disease Trials 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: