Navigation Links
Biomarker Spots Which Lesions Likely to Progress to Prostate Cancer
Date:5/2/2008

Finding could help men with precancerous lesions avoid unnecessary needle biopsies

FRIDAY, May 2 (HealthDay News) -- Spanish researchers report they may have found a way to tell which suspicious prostate lesions are likely to develop into cancer.

The findings, published in the May 1 issue of Clinical Cancer Research, show a link between high-grade prostatic intraepithelial neoplasia (HG-PIN) lesions and the PTOV1 gene. The more PTOV1 the lesion expresses, the more likely cancer will develop. The report also backs the reverse -- that the lack of PTOV1 means a reduced risk of prostate cancer.

PTOV1 is a protein that researchers don't fully understand the function of, but they have previously found too much of it appears to promote the spread of cancer cells.

If subsequent studies confirm PTOV1 as a biomarker for prostate cancer, it could help men with the lesions avoid repeated needle biopsies.

"Those patients with a high PTOV1 score should undergo an immediate repeat biopsy," study author Rosanna Paciucci, a researcher at the Vall d'Hebron Hospital Research Institute in Barcelona, said in a prepared statement. But those with low PTOVI may not need to receive future "annoying and useless" biopsies, she said. "We estimate that we can save 40 percent of unnecessary biopsies -- those that are repetitively negative and contain HG-PIN lesions that do not develop into cancer."

HG-PIN, while present in most cancerous prostates, is a pre-malignant lesion and, given its association with other cancers, it is often repeatedly biopsied when found. Past studies have put the average risk of cancer being diagnosed in a HG-PIN biopsy at between 20 percent and 30 percent, the researchers said. However, none of these studies were to tell which lesions would progress to cancer, the researchers say.

Paciucci cautioned that her team's results need to be confirmed through a larger study group. "From
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. New Thomson Reuters Biomarkers Report Shines a Light on Revolutionary New Area of Drug Development
2. Biomarker May Predict Response to Cancer Therapy
3. Biomarkers may reduce need for biopsies
4. Scientists: New technique identifies molecular biomarkers for disease
5. Biomarker May Signal HIV Progression
6. Expansion of monocyte subset could serve as a biomarker for HIV progressions
7. Biomarkers and Innovation Push Global Cancer Diagnostics Market Toward $8 Billion
8. Biomarkers for Mood May Alter Psychiatric Treatments
9. UCLA researchers discover biomarkers that predict lung cancer patient response to therapy
10. Proteomic profiling shown more accurate than traditional biomarkers in identifying liver cancer
11. New developments in biomarkers for epithelial ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Biomarker Spots Which Lesions Likely to Progress to Prostate Cancer
(Date:12/21/2014)... York, NY (PRWEB) December 21, 2014 ... nearing 1,400 in a consolidated litigation underway in New ... documents, a total of 1,375 claims involving the birth ... Superior Court. These lawsuits were filed by women who ... to have led to uterine perforations and other complications ...
(Date:12/21/2014)... California (PRWEB) December 21, 2014 Serious ... search for Vintage 1967 Jm Morrison and the Doors International ... posters. This would also be the only time that ... concert was on Nov. 25, 1967. According to Hawley, ... D.C. They did play the Alexandria Roller Rink earlier ...
(Date:12/21/2014)... 2014 Over the past 39 years, ... hundreds of emergency departments across the nation, from quality ... been translated into an innovative suite of tools, systems, ... and enhance the patient experience. , NES Health, ... and management services for hospitals, announced the development and ...
(Date:12/21/2014)... Viejo, California (PRWEB) December 21, 2014 ... Studios have announced a new intro plugin for Final ... to animate pictures, videos, logos, and more with absolute ... “We’ve given our users the tools needed to easily ... ProMotion allows Final Cut Pro X users to animate ...
(Date:12/21/2014)... CannabisClassifieds.com celebrates marijuana’s new legal place at ... of its kind, the site has provided its faithful users ... years running. It uniquely combines the benefits of platforms ... available to the masses. Assuring the potent herb’s followers ... of public approval. , Shane Chattin, Owner of ...
Breaking Medicine News(10 mins):Health News:Mirena Lawsuits Approach 1,400 in Bergen County Litigation, Bernstein Liebhard LLP Reports 2Health News:Mirena Lawsuits Approach 1,400 in Bergen County Litigation, Bernstein Liebhard LLP Reports 3Health News:NES Health Launches Stipend Program for Emergency Physicians in Training to Financially Assist Emergency Department Doctors While They Learn 2Health News:Announcing a new plugin for Final Cut Pro X ProMotion from Pixel Film Studios. 2Health News:CannabisClassifieds.com Maintains its “Craigslist for Cannabis” Standing with Website Re-launch 2
... WEDNESDAY, Dec. 28 (HealthDay News) -- State highway safety offices ... through Monday, Jan. 2, in an effort to target drunk ... are teaming up with local police forces to identify more ... considers drinking and driving should know that police are out ...
... HealthDay Reporter , TUESDAY, Dec. 27 (HealthDay News) ... of the body and who are treated with radiation therapy ... that lead to the heart, researchers say. A ... narrowed coronary arteries was more than four times greater for ...
... in intensive care units (ICUs) in Europe and Israel indicated ... of care for a patient, was common, and that these ... autonomy, according to a study in the December 28 issue ... they provide as inappropriate when they feel that it clashes ...
... , TUESDAY, Dec. 27 (HealthDay News) -- Poor people ... suffering of others and to show compassion, according to a ... who were divided into groups that took part in three ... The findings challenge previous research that concluded lower-class people ...
... disease of the major arterial blood vessels. It is one ... proinflammatory molecule IL-1 has been linked to atherosclerosis and a ... for IL-1-beta is being studied for its effects on the ... However, a team of researchers led by Gary Owens, ...
... , TUESDAY, Dec. 27 (HealthDay News) -- No doubt about ... which elicit a wide range of emotional responses by their ... days, animals are being involved in human therapy in innovative ... "Most people think of nursing homes, and people going ...
Cached Medicine News:Health News:States Crack Down on Drunk Drivers This Holiday Season 2Health News:Breast Cancer Radiation Linked to Raised Heart Risk 2Health News:Breast Cancer Radiation Linked to Raised Heart Risk 3Health News:Perception of inappropriate care frequent among ICU workers 2Health News:Perception of inappropriate care frequent among ICU workers 3Health News:Poor People May Be Quicker to Be Kind 2Health News:The New Face of Pet Therapy 2Health News:The New Face of Pet Therapy 3
(Date:12/17/2014)... and SAN DIEGO , Dec. 17, ... PHG ; AEX: PHIA) and Volcano Corporation (NASDAQ: ... solutions for cardiovascular applications, today announced that they have entered ... will commence a tender offer to acquire all of the ... share, or a total equity purchase price of USD 1 ...
(Date:12/17/2014)... 17, 2014  Northstar Global Business Services, Inc. ... (DTC) has made their final decision and has ... Company,s stock effective December 15, 2014, and has ... depository and book entry transfer services. All deposit restrictions ... once again fully "DTC Eligible", and has resumed ...
(Date:12/17/2014)... , Dec. 17, 2014  ImmunoCellular Therapeutics, Ltd. ... Patent and Trademark Office (USPTO) has issued a ... dendritic cell-based immunotherapeutic vaccine targeting six tumor antigens ... of US Patent No. 8,871,211, which issued October ... by administering a dendritic cell composition comprising peptide ...
Breaking Medicine Technology:Philips to acquire Volcano to expand global leadership position in image-guided therapy market 2Philips to acquire Volcano to expand global leadership position in image-guided therapy market 3Philips to acquire Volcano to expand global leadership position in image-guided therapy market 4Philips to acquire Volcano to expand global leadership position in image-guided therapy market 5Philips to acquire Volcano to expand global leadership position in image-guided therapy market 6Philips to acquire Volcano to expand global leadership position in image-guided therapy market 7Philips to acquire Volcano to expand global leadership position in image-guided therapy market 8Northstar announces that the DTC chill on MDIN has been officially lifted 2Northstar announces that the DTC chill on MDIN has been officially lifted 3ImmunoCellular Therapeutics Announces Issuance of Key Patent For ICT-107 Cancer Vaccine 2
... ... research and biotechnology companies are testing 97 medicines and vaccines to ... report released today by the Pharmaceutical Research and Manufacturers of America ... - a global awareness campaign that originated at the 1988 World ...
... , XI,AN, China, Nov. ... a leading developer and producer,of plant extracts and pharmaceutical raw ... China, today reported that in its,third quarter, the company realized ... Revenues for the quarter ended Sept. 30, 2009 were $4,465,770, ...
Cached Medicine Technology:New Report Shows 97 Medicines and Vaccines Currently in Development for HIV/AIDS 2New Report Shows 97 Medicines and Vaccines Currently in Development for HIV/AIDS 3Huifeng Bio-Pharmaceutical Technology Reports 26% Quarterly Revenue Increase 2Huifeng Bio-Pharmaceutical Technology Reports 26% Quarterly Revenue Increase 3Huifeng Bio-Pharmaceutical Technology Reports 26% Quarterly Revenue Increase 4
... CardioSEAL is a second generation device, ... was tested in over 700 patients beginning ... of leading pediatric cardiologists who perform these ... computer simulations, on the engineering bench, and ...
... YAG laser YC-1600 is a lightweight, compact, ... and clinical performance., ,Key Features, , ... Model ,Further weight reduction has been made ... office.,, Aiming Beam Rotation ,(360 degrees ...
... delivers a solid-state green laser ... and plugs into any standard ... and extreme portability, the unit ... Nidek Phaco Emulsification System CV-24000 ...
... is an effective angina relief ... poor targets. Because it is ... the CO2 Heart Laser 2 ... timely operative decisions to revascularize ...
Medicine Products: