Navigation Links
Biomarker Spots Which Lesions Likely to Progress to Prostate Cancer
Date:5/2/2008

Finding could help men with precancerous lesions avoid unnecessary needle biopsies

FRIDAY, May 2 (HealthDay News) -- Spanish researchers report they may have found a way to tell which suspicious prostate lesions are likely to develop into cancer.

The findings, published in the May 1 issue of Clinical Cancer Research, show a link between high-grade prostatic intraepithelial neoplasia (HG-PIN) lesions and the PTOV1 gene. The more PTOV1 the lesion expresses, the more likely cancer will develop. The report also backs the reverse -- that the lack of PTOV1 means a reduced risk of prostate cancer.

PTOV1 is a protein that researchers don't fully understand the function of, but they have previously found too much of it appears to promote the spread of cancer cells.

If subsequent studies confirm PTOV1 as a biomarker for prostate cancer, it could help men with the lesions avoid repeated needle biopsies.

"Those patients with a high PTOV1 score should undergo an immediate repeat biopsy," study author Rosanna Paciucci, a researcher at the Vall d'Hebron Hospital Research Institute in Barcelona, said in a prepared statement. But those with low PTOVI may not need to receive future "annoying and useless" biopsies, she said. "We estimate that we can save 40 percent of unnecessary biopsies -- those that are repetitively negative and contain HG-PIN lesions that do not develop into cancer."

HG-PIN, while present in most cancerous prostates, is a pre-malignant lesion and, given its association with other cancers, it is often repeatedly biopsied when found. Past studies have put the average risk of cancer being diagnosed in a HG-PIN biopsy at between 20 percent and 30 percent, the researchers said. However, none of these studies were to tell which lesions would progress to cancer, the researchers say.

Paciucci cautioned that her team's results need to be confirmed through a larger study group. "From this validation, we can expect to improve the current rate of early detection of cancer," she said.

More information

The U.S. National Cancer Institute has more about prostate cancer.



-- Kevin McKeever



SOURCE: American Association for Cancer Research, news release, May 1, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Thomson Reuters Biomarkers Report Shines a Light on Revolutionary New Area of Drug Development
2. Biomarker May Predict Response to Cancer Therapy
3. Biomarkers may reduce need for biopsies
4. Scientists: New technique identifies molecular biomarkers for disease
5. Biomarker May Signal HIV Progression
6. Expansion of monocyte subset could serve as a biomarker for HIV progressions
7. Biomarkers and Innovation Push Global Cancer Diagnostics Market Toward $8 Billion
8. Biomarkers for Mood May Alter Psychiatric Treatments
9. UCLA researchers discover biomarkers that predict lung cancer patient response to therapy
10. Proteomic profiling shown more accurate than traditional biomarkers in identifying liver cancer
11. New developments in biomarkers for epithelial ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Biomarker Spots Which Lesions Likely to Progress to Prostate Cancer
(Date:8/18/2017)... ... August 18, 2017 , ... ... services to communities in east Texas, is launching a regional charity effort to ... Founded in 1991, the Pediatric Brain Tumor Foundation (PBTF) has raised nearly $30 ...
(Date:8/18/2017)... Bedford, TX (PRWEB) , ... August 18, 2017 , ... ... serves communities in the Dallas/Fort Worth area, is spearheading a regional charity campaign organized ... her husband. , In early June of this year, Christina and her children returned ...
(Date:8/18/2017)... ... 2017 , ... Alcovit, a lime-flavored beverage that rids the body of toxins ... product now available through Jet.com. , After 25 years of development, the company ... designed to quickly detox the body thereby avoiding alcohol-induced hangovers. Whether you’re having fun ...
(Date:8/18/2017)... , ... August 18, 2017 , ... “Dangerous Inheritance”: a ... author, Diane Winters. Diane is from Southwest Nebraska where she was raised on ... and family. The story is fictional, but the friendships and mantra of ‘neighbors ...
(Date:8/18/2017)... ... August 18, 2017 , ... Rollon Skin ... anti-aging skincare solutions, recently announced the launch of two new skincare products, ... yet effective alternative to expensive plastic surgery or in-patient cosmetic dermatological procedures. , ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... -- Agragen, LLC, a Cincinnati -based ... and aquacultural feed sectors, announces a significant step ... AGR131.  This drug is designed to trap and ... patients suffering from inflammatory conditions such as rheumatoid ... Biological pharmaceuticals currently used ...
(Date:8/2/2017)...   Marshall County Hospital in Benton, Kentucky has added ... hospital-acquired infections (HAIs). The new addition, Tru-D SmartUVC , short for "total room ultraviolet ... such as C. diff , MRSA, MERS, Ebola and more. ... Tru-D SmartUVC ... Tru-D in action in a patient room ...
(Date:8/1/2017)...   CerSci Therapeutics , a non-opioid drug development ... has received notice from the National Institute on Drug ... that it has been awarded a Direct-to-Phase II Small ... 2017 with an additional $1,000,000 to follow in 2018. ... of their lead non-opioid drug candidate CT-044 to the ...
Breaking Medicine Technology: