Navigation Links
Biomarker May Predict Response to Cancer Therapy

Dutch researchers identify cell type that is potential target for these agents

SUNDAY, April 13 (HealthDay News) -- A biomarker that may help doctors monitor the effectiveness of common treatments for kidney cancer and non-small cell lung cancer has been identified by researchers in the Netherlands.

The researchers found that CD34bright/CD133neg candidate circulating Endothelial Progenitor Cells (ccEPCs) are a potential biomarker during treatment with sunitinib (Sutent) or bevacizumab (Avastin).

"Our work provides novel data on a potential biomarker for the monitoring of anti-angiogenic drug activity in cancer patients, as well as identifies a cell type that is a potential target for these agents," Laura Vroling, a researcher in the department of medical oncology at VU University Medical Center in Amsterdam, said in a prepared statement.

Vroling and her colleagues noted that bevacizumab and sunitinib, which target the vascular endothelial growth factor (VEGF), have proven effective against a number of cancers, but doctors aren't able to determine which patients might derive the most benefit from these drugs.

"Therefore, it is of great importance to identify and validate biomarkers for early response or duration of response," Vroling said.

She and her team studied 23 patients with renal cell cancer and 19 patients with non-small cell lung cancer.

"In our study, for the first time, the behavior of two CD34bright cell populations, (CD45neg) candidate cEPcs and (CD45dim) HPCs (hematopoietic progenitor cells), were monitored and showed a different response of both cell populations during sunitinib or bevacizumab therapy. The role of ccEPCs in human tumor angiogenesis and their potential in prediction of treatment outcome of anti-VEGF therapy needs to be addressed in future, larger clinical cohorts," Vroling said.

The study findings were to be presented Sunday at the annual meeting of the American Association for Cancer Research, in San Diego.

More information

The National Academies Press has more about cancer biomarkers.

-- Robert Preidt

SOURCE: American Association for Cancer Research, news release, April 13, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Biomarkers may reduce need for biopsies
2. Scientists: New technique identifies molecular biomarkers for disease
3. Biomarker May Signal HIV Progression
4. Expansion of monocyte subset could serve as a biomarker for HIV progressions
5. Biomarkers and Innovation Push Global Cancer Diagnostics Market Toward $8 Billion
6. Biomarkers for Mood May Alter Psychiatric Treatments
7. UCLA researchers discover biomarkers that predict lung cancer patient response to therapy
8. Proteomic profiling shown more accurate than traditional biomarkers in identifying liver cancer
9. New developments in biomarkers for epithelial ovarian cancer
10. Biomarkers for Alzheimers disease can be trusted in clinical trials
11. JDRF and Lilly partner to fund research to identify beta cell biomarkers
Post Your Comments:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, ... remain in the eye of the beholder, according to experts who offered insights and ... Journal of Managed Care. For the full issue, click here . , For ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/26/2016)... ... 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to ... app. The fitness app plans to fix the two major problems leading the fitness industry ... fits all type program , They don’t eliminate all the reasons people quit ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on ... Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ability ... fumigation is not a common occurrence, but a necessary one in the event that lice ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
(Date:6/23/2016)...  MedSource announced today that it has selected ... of choice.  This latest decision demonstrates MedSource,s commitment ... clients by offering a state-of-the-art electronic data capture ... as the EDC platform of choice in exchange ... has long been a preferred EDC platform by ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Pharmaceutical Excipients Market by Type (Organic Chemical ... Preservative), Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast ... The global pharmaceutical excipients ... 2021 at a CAGR of 6.1% in the forecast ...
Breaking Medicine Technology: