Navigation Links
Biomarker Could Predict Severe Osteoarthritis
Date:7/30/2009

Those with highest levels are more apt to have joint replacement, study finds

THURSDAY, July 30 (HealthDay News) -- Levels of a certain protein strongly predict the risk of hip and knee joint replacement as a result of severe osteoarthritis, a new study shows.

The research involved 912 healthy people in Italy, including 60 who had severe osteoarthritis that led to a knee or hip replacement between 1990 and 2005. Those with high levels of vascular cell adhesion molecule 1 (VCAM-1) at the start of the study were most likely to undergo joint replacement, the study found. VCAM-1 is expressed on cells in the cartilage and connective tissue.

"The level of VCAM-1 emerged as a significant predictor of the risk of joint replacement due to severe OA, equaling or even surpassing the effects of age," wrote Georg Schett, of the University of Erlangen-Nuremburg in Germany, and his colleagues.

They also found that including VCAM-1 levels in risk prediction models led to more accurate classification of patients.

The study, which appears in the August issue of Arthritis & Rheumatism, is the first to establish a laboratory biomarker for the risk of severe osteoarthritis, according to background information in a news release from the journal. Such biomarkers can lead to early diagnosis of the disease, before clinical symptoms appear. Improved prediction of severe osteoarthritis, experts say, could help identify people who would benefit from interventions such as weight loss, strength training and aerobic exercise.

The researchers said that learning more about the underlying mechanism in the link between VCAM-1 and osteoarthritis might also help improve understanding about the causes of the joint disease.

More information

The Arthritis Foundation has more about osteoarthritis.



-- Robert Preidt



SOURCE: Arthritis & Rheumatism, news release, July 30, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. First biomarker discovered that predicts prostate cancer outcome
2. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
3. Study makes progress in zoning in on biomarkers for better colon cancer treatment
4. New Ovarian Cancer Biomarker Research Act Introduced
5. Mayo Clinic study points to a possible biomarker for colon cancer in people 50 and under
6. Singulex Announces Presentation on Monitoring of Cardiac Biomarker to Assess Transient Myocardial Ischemia at the American Heart Association Scientific Sessions
7. Biomarker may be an early predictor of advanced breast cancer
8. Millennium Announces MLN1202 Significantly Reduced Marker of Systemic Inflammation and Identifies Genomic Biomarker For Responders
9. Biomarkers predict risk for invasive breast cancer years before the tumor develops
10. JDRF and Lilly partner to fund research to identify beta cell biomarkers
11. Biomarkers for Alzheimers disease can be trusted in clinical trials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Biomarker Could Predict Severe Osteoarthritis
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department ... in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at ... Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 ...
(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... ... Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair ... hour by 2020 and then adjusting it yearly to increase at the same rate as ... the wage floor does not erode again, and make future increases more predictable. , The ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital ... area economy by obtaining investment capital for emerging technology companies. SCP has ... have already resulted in more than a million dollars of capital investment for ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 2016  VMS Rehab Systems, Inc. ( www.vmsrehabsystemsinc.com ) ... measures required to build a strong and stable market ... listed on the OTC Markets-pink current trading platform. ... "We are seeing an anomaly in market trading activities ... by the Company, but shareholders and market players as ...
(Date:6/24/2016)... 24, 2016   Bay Area Lyme Foundation ... Dean Center for Tick Borne Illness , Harvard ... MIT Hacking Medicine, University of California, Berkeley, and ... the five finalists of Lyme Innovation , ... than 100 scientists, clinicians, researchers, entrepreneurs, and investors ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, 2016 ... mobile pulmonary function testing company, is now able to perform sophisticated ... by ndd Medical Technologies , Inc. Patients ... hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients ... get any needed testing done in the comfort of her own ...
Breaking Medicine Technology: