Navigation Links
Biologists Discover How Dengue Virus Matures

Finding may aid efforts to treat other infections

THURSDAY, March 27 (HealthDay News) -- The way dengue virus matures and becomes infectious has been determined by biologists at Purdue University in Indiana.

The dengue virus, which is spread by mosquitoes, infects more than 50 million people a year and kills about 24,000, primarily in tropical regions. The virus is prevalent in Southeast Asia, Central America and South America.

The Purdue team identified important changes that occur as the virus is assembled and moves from the inner to the outer portions of a host cell before the virus is secreted and can infect other cells.

Virus particles are exposed to progressively less acidic conditions as they move along this "secretory pathway." The changing acidity plays a critical role in the maturation of the Dengue virus.

"This is possibly the most detailed understanding of how any virus matures," research co-author Michael Rossmann, a professor of biological sciences, said in a prepared statement.

He noted that there's been extensive research into pathways used by viruses to enter new host cells, but the way that viruses move out of host cells to infect other cells isn't well understood.

These findings, published in the March 28 issue of Science, pertain to all other flaviviruses, which include other dangerous insect-borne disease such as West Nile, yellow fever, and St. Louis encephalitis, the researchers said.

This research may help in efforts to find ways to treat or prevent viral infections.

More information

The U.S. Centers for Disease Control and Prevention has more about dengue fever.

-- Robert Preidt

SOURCE: Purdue University, news release, March 27, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. First biomarker discovered that predicts prostate cancer outcome
2. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Discovery of sugar sensor in intestine could benefit diabetes
5. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
6. Discover The Mutter Museum After Dark
7. Stem cell research produces a key discovery for Fragile X Syndrome
8. Welch Foundation gives $1.6 million for drug discovery research
9. Researchers discover correlation between GERD and obesity in females
10. New discovery leaves blood-doping athletes scratching their heads
11. Chemical Diversity Initiates International Prostrate Cancer Discovery Partnership
Post Your Comments:
(Date:12/1/2015)... ... 01, 2015 , ... The workstation boundaries for imaging specialists ... Systems launches MED-TAB™ -- the world’s first portable DICOM-calibrated medical image display, debuting ... December 4, 2015. , MED-TAB is expected to change teleradiology because for ...
(Date:12/1/2015)... IL (PRWEB) , ... December 01, 2015 , ... ... keeping their independence is everything. That is why Hollister Incorporated has launched the ... to offer this next product in the VaPro touch free catheter portfolio,” said ...
(Date:12/1/2015)... ... December 01, 2015 , ... McLean, VA., ... awarded a fixed price per sprint agile development contract to support the National ... over five years, provides software engineering, infrastructure, as well as operations and sustainment ...
(Date:12/1/2015)... ... December 01, 2015 , ... XTC Semifinals 2016 - ... to head to Las Vegas for CES 2016, the world’s largest Consumer Electronic Show, ... Technology Association Gary Shapiro, Founding Partner of Pacific Investments Veronica Serra, and venture capitalist ...
(Date:12/1/2015)... ... December 01, 2015 , ... Dr. Arash ... Modern Man for 2015. , Angeleno Magazine is a division of Modern ... in 1994, Modern Luxury includes more than 50 magazine titles across 15 major ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... VIEJO, Calif. , Dec. 1, 2015 /PRNewswire/ ... the prevalence of symptoms for pseudobulbar affect (PBA), ... outbursts of laughing and/or crying resulting from certain ... use of antipsychotic medications in nursing home residents, ... Geriatric Psychiatry. The study showed that almost one ...
(Date:12/1/2015)... 1, 2015 ... of the  "2016 Shigella Testing Market: ... Competitive Strategies, Emerging Opportunities--US, Europe (France, ... to their offering. --> ... of the  "2016 Shigella Testing Market: ...
(Date:11/30/2015)... BASEL, Switzerland , Dec. 1, 2015 ... through its wholly-owned UK subsidiary Proximagen Ltd., today announced ... novel, oral small molecule inhibitor of Vascular Adhesion Protein ... in the treatment of inflammatory disease. The VAP-1 inhibitor ... --> --> Under the terms ...
Breaking Medicine Technology: