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Biologist finds plant polymerases IV and V are really variants of Polymerase II
Date:1/6/2009

lecular Cell paper is one of three related papers published by the Pikaard lab in rapid succession. In a paper published Nov. 14, 2008 in Cell, Pikaard and his colleagues explain how Pol IV and Pol V work together to use the non-coding region of DNA to prevent destructive, virus-derived genes from being activated. Then in a paper published Dec. 4 in Molecular Cell, the Pikaard lab announced a breakthrough in understanding the phenomenon of nucleolar dominance, the silencing of an entire parental set of ribosomal RNA genes in a hybrid plant or animal. That study is one of the first to demonstrate how siRNAs can play a role in controlling the dosage of vital genes, and not just harmful genes, and implicates the pathway in which Pol IV and Pol V function. The research has been supported by the National Institutes of Health and by the National Science Foundation.


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Contact: Craig Pikaard
pikaard@wustl.edu
314-935-7569
Washington University in St. Louis
Source:Eurekalert

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