Navigation Links
Biologist finds plant polymerases IV and V are really variants of Polymerase II
Date:1/6/2009

It's a little like finding out that Superman is actually Clark Kent. A team of biologists at Washington University in St. Louis has discovered that two vital cellular components, nuclear RNA Polymerases IV and V (Pol IV and V), found only in plants, are actually specialized forms of RNA Polymerase II, an essential enzyme of all eukaryotic organisms, including humans.

"We've caught evolution in the act," said Craig Pikaard, Ph.D., Washington University professor of biology in Arts & Sciences. "We've known for decades that RNA Polymerases I, II and III are found in all eukaryotes, but it's only over the past several years that we've been aware that plants have two more nuclear polymerases, Pol IV and Pol V. Now it is clear that these enzymes evolved from Pol II over the past several hundred millions years. This is a new snapshot into the evolution of RNA polymerases, which are the enzymes responsible for decoding the information stored in the chromosomes".

Analyzing purified Pol IV and Pol V by a sophisticated technique known as tandem mass spectrometry, the Pikaard lab and a team of collaborators at Pacific Northwest National Laboratory, led by Ljiljana Paa-Toli?, discovered 12 subunits in both Pol IV and Pol V that correspond one-for-one to the 12 subunits of Pol II. Some of the Pol IV and Pol V subunits are encoded by the same genes as the corresponding Pol II subunits, but others come from duplicated Pol II subunit genes that have changed over time. Overall, four subunits of Pol IV are distinct from their Pol II counterparts, six subunits of Pol IV are different from their Pol II counterparts, and four subunits differ between Pol IV and Pol V. Yet, all of the Pol IV and Pol V subunits are "apples that haven't fallen far from the Pol II tree."

The finding is important because it reveals more about the roles played by RNA in complex organisms. RNA polymerases are the enzymes responsible for making R
'/>"/>

Contact: Craig Pikaard
pikaard@wustl.edu
314-935-7569
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Cell biologists identify new tumor suppressor for lung cancer
2. Reeve Foundation Recruits Distinguished Stem-Cell Neurobiologist - The Salk Institutes Samuel L. Pfaff, Ph.D. - to its International Research Consortium
3. Microbiologists receive top Canadian recognition
4. UCR cell biologist co-leads joint international conference on wound healing
5. Boston College biologists build a better mouse model for cancer research
6. Biologists Discover How Dengue Virus Matures
7. Stanford biologist awarded 2008 Sophie Prize in Norway
8. New book by UCR biologist discusses 12 diseases that impacted humanity
9. Folic acid survey of Spanish-speaking women finds most are missing benefits, March of Dimes says
10. First Nationwide Folic Acid Survey of Spanish-Speaking Women Finds Most Are Missing Benefits, March of Dimes Says
11. Researcher Finds Most Will Inflict Pain on Others If Prodded
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... Fort Collins, CO (PRWEB) October 20, 2014 ... platform, dGH assays are the only imaging assays ... data in a single test.  With these three ... in their ability to detect the widest range ... chromosomal translocations—mutations usually missed by other genomic tools, ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Unveiled at the ... Strategic Direction Scorecard conservatively estimates member hospital ROI on membership ... on dues, The Center provides $12.50 in value to member ... (Member Value – Member Dues)/Member Dues. , “This is ... this number and we think the methodology is really sound,” ...
(Date:10/20/2014)... Houston plastic surgeon Dr. Christopher Patronella ... his innovative True Form Tummy Tuck® method ... faculty at The University of Texas Medical Branch ... a medical student. Patronella, who is a founding partner ... practices in Texas, The Aesthetic Center for Plastic ...
(Date:10/19/2014)... The leading review website, Top10BestSEOHosting.com, has recently announced ... the best Dedicated Server Hosting suppliers. Their websites ... buy high quality hosting and save money at ... Top10BestSEOHosting.com says, “We believe that iPage and GreenGeeks ... lot of the global clients enjoy using their ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 This ... for Partial Seizure, complete with comparative analysis at ... of action (MoA), route of administration (RoA) and ... news and press releases. It also reviews key ... Seizure and special features on late-stage and discontinued ...
Breaking Medicine News(10 mins):Health News:KromaTiD Launches Genome Screening and Discovery Services 2Health News:KromaTiD Launches Genome Screening and Discovery Services 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 4Health News:Plastic Surgeon Patronella Presents Artistically-Inspired Tummy Tuck Method to Future Generation of Plastic Surgeons in Texas 2Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 2Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 3Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 4
... running, jogging on physical health have been known for a ... Germany that running can improve the mental health status as ... // ,The study participants had to complete a minimum of ... had to take up progressively difficult tests. The researchers examined ...
... has been lifted on account of no single case of bird ... racing, falconry and other bird shows were regularly conducted in Britain.// ... which was detected in Eastern Europe the events were banned to ... of bird flu was reported the health officials are planning to ...
... of two drugs in a rare medical trail. These drugs ... ,They are anti-retroviral drugs which have been studied individually ... are unapproved for the usage in AIDS patient and hence ... usage of this new unapproved AIDS drug started nine months ...
... human cancer cells in a unique way will be ... Zealand. The clinical trial would be held at New ... on Wednesday. ,Auckland University cancer researcher Professor Bill ... is converted to a DNA damaging agent in the ...
... treatment of Ambylopia or lazy eye as it is commonly called. ... at the USC and three other Chinese universities. //,A ... compromise in the vision even when corrective glasses are used. If ... condition has been regarded to be incurable in children over 8 ...
... says that elderly white women who have had non-melanoma skin ... of their exposure to the harmful rays of the sun. ... age group of 50 to 79, who had a previous ... the skin, had a two-fold increase in the risk of ...
Cached Medicine News:Health News:Health Canada Gave Access To Unapproved Drugs To AIDS/HIV Patients. 2
(Date:10/17/2014)...  Hanger, Inc. (NYSE: HGR ) announced ... operations for the quarter ended September 30, 2014, on ... conference call to discuss these results is scheduled to ... 2014. Those wishing to participate should call 1-877-662-6095. A ... by dialing 1-855-859-2056 and referencing Conference ID # 91880739. ...
(Date:10/17/2014)... October 17, 2014 ... has announced the addition of the  "China ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... in China impacted ... in consumption concept, dietary habit, way of ...
(Date:10/17/2014)... DUBLIN , October 17, 2014 ... Research and Markets ( http://www.researchandmarkets.com/research/rxznjk/micro_market ) has ... Market Monitor : North American Automated ... their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,The ... forecast, 2008-2018 analyzes the market of ...
Breaking Medicine Technology:China Interventional Cardiovascular Device Industry Report 2014-2017 2China Interventional Cardiovascular Device Industry Report 2014-2017 3Micro Market Monitor : North American Automated External Defibrillators (AED) Market 2
... responses on hot-button HIV/AIDS ... issues, Clinton, Edwards, Obama and Kucinich support ending ... for ... the AIDS Foundation of Chicago -- three of the,nation,s leading AIDS organizations -- polled 16 ...
... Radiologists are using a new minimally,invasive procedure to ... reduces pain from calcific tendonitis of,the rotator cuff ... at the annual meeting of the Radiological Society ... successful and inexpensive therapy for tendon,calcifications," said Luca ...
Cached Medicine Technology:Leading AIDS Groups Turn Up The Heat on '08 Presidential Candidates 2Leading AIDS Groups Turn Up The Heat on '08 Presidential Candidates 3Minimally Invasive Treatment Reduces Shoulder Pain From Tendonitis 2Minimally Invasive Treatment Reduces Shoulder Pain From Tendonitis 3
... Our new oversized wheelchair scales incorporate all ... model including automatic zero, weight recall, reweigh ... displays weight in pounds and kilos., ... patients in electric and oversized wheelchairs. The ...
This high-capacity stand-on scale provides extra sensitivity and support to patients who are unsteady on their feet. Advanced technology compensates for patient movement....
... Endo-PAT2000 is a simple and easy to ... PAT signal is recorded using Itamar Medical's ... is analyzed automatically using proprietary advanced Digital ... within seconds of completing the test. The ...
... C-peptide of insulin is the C-terminal cleavage ... prohormone to the mature insulin molecule. Although ... it does undergo significant liver or extra-renal ... circulating half-life than insulin [1]. In addition, ...
Medicine Products: