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Biologics-naive juvenile idiopathic arthritis patients have elevated risk of cancer
Date:6/17/2010

ational JIA cohort of 9,020 patients. For each JIA patient, up to five general-population comparators were identified (n=44,858). In the biologics-nave JIA cohort, 60 cancers were observed during 131,144 person-years compared to 266 cancers during 661,758 person-years in the population comparator. Researchers noted that sensitivity analyses did not reveal an explanation for the differences seen between patients identified before and after 1987.

The results of the second study combined data on 1,721 patients treated with etanercept from three prospective JIA registries in Germany, the UK and the US. Of the 1,641 patients who qualified for the primary analysis, two cancers were reported. Whilst this yielded a rate higher than expected when compared to the general population, it was not statistically significant (RR estimated using a Standardized Incident Ratio (SIR) of 3.7 (0.5-13.4, 95%CI)). This is believed to be in part due to the low event rate. The interpretation of these findings may be further limited by the fact that the comparator rates were based on a general population and not a biologics-nave JIA population, as per the Swedish study, which suggests this may indicate an increased underlying risk of cancer.


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Contact: Caroline Butt
eularpressoffice@uk.cohnwolfe.com
44-778-927-0392
European League Against Rheumatism
Source:Eurekalert

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