Navigation Links
Biologics-naive juvenile idiopathic arthritis patients have elevated risk of cancer
Date:6/17/2010

Rome, Italy, Thursday 17 June 2010: Biologics-nave Juvenile Idiopathic Arthritis (JIA) patients may have an increased risk of cancer compared with the general Swedish population, according to research presented today at EULAR 2010, the Annual Congress of the European League Against Rheumatism in Rome, Italy. Results of an additional study, which researched a small cohort of patients showed an increased frequency of cancer in those receiving the biologic etanercept, however, results were deemed not statistically significant by researchers.

The results of a population-based Swedish cohort study found that the incidence of cancer among paediatric patients with JIA identified during the last 40 years was comparable to that seen in the general population, (0.5 vs. 0.4 cases per 1000 person years, Relative Risk (RR)=1.1, 95%CI 0.9-1.5). Subset analyses however indicated that subjects diagnosed with JIA since 1987 (the year that the Swedish patient registry attained nationwide coverage) were at elevated risk of developing cancer (RR=2.3, 95%CI 1.2-4.4, 13 JIA cancers vs. 30 in comparator), attributed to an increased occurrence of cancers of the lymphatic system (RR=4.2, 95%CI 1.7-10.7, 8 cancers in JIA vs. 10 in comparator).

"These results are intriguing and suggest that in the past 20 years, patients with JIA not treated with biological therapies appear to have an elevated risk of cancer compared with the general population," said lead author of the study Dr. Julia Simard, Clinical Epidemiology Unit, Karolinska Institute, Stockholm, Sweden. "The results of our study indicate that evaluation of cancer risks with biologics in paediatric populations need to factor in differences in incidence of cancer between these patients and the general population. From a clinical point of view, it should be remembered that although we noted an increased risk in relative terms, the excess risks remain low in absolute terms."

The Swedish study assessed a national JIA cohort of 9,020 patients. For each JIA patient, up to five general-population comparators were identified (n=44,858). In the biologics-nave JIA cohort, 60 cancers were observed during 131,144 person-years compared to 266 cancers during 661,758 person-years in the population comparator. Researchers noted that sensitivity analyses did not reveal an explanation for the differences seen between patients identified before and after 1987.

The results of the second study combined data on 1,721 patients treated with etanercept from three prospective JIA registries in Germany, the UK and the US. Of the 1,641 patients who qualified for the primary analysis, two cancers were reported. Whilst this yielded a rate higher than expected when compared to the general population, it was not statistically significant (RR estimated using a Standardized Incident Ratio (SIR) of 3.7 (0.5-13.4, 95%CI)). This is believed to be in part due to the low event rate. The interpretation of these findings may be further limited by the fact that the comparator rates were based on a general population and not a biologics-nave JIA population, as per the Swedish study, which suggests this may indicate an increased underlying risk of cancer.


'/>"/>

Contact: Caroline Butt
eularpressoffice@uk.cohnwolfe.com
44-778-927-0392
European League Against Rheumatism
Source:Eurekalert

Related medicine news :

1. BestofNorthCarolina.com Presents Their Inaugural 'Carolina Beach Bash' to Benefit the Juvenile Diabetes Research Foundation
2. Most states offer HPV vaccinations to girls in juvenile justice system
3. Montreal researchers shed light on common juvenile cancer
4. Diffuse idiopathic skeletal hyperostosis causes dysphagia in older patients
5. Arthritis simulation gloves aid companies in designing easy-to-use products
6. Long Before Symptoms, Blood May Reveal Rheumatoid Arthritis
7. Biomarker could help doctors tailor treatment for rheumatoid arthritis
8. Vibrant Health Co Sponsors Specialty Arthritis Pain Relief Blog, painreliefcream.info
9. Blood test can predict rheumatoid arthritis before symptoms arise
10. Rheumatoid arthritis doesnt hinder computing skills
11. How arthritis thrives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... 02, 2016 , ... In honor of National Physical Fitness and Sports Month ... share their fitness journey on social media. , The foot care company, which ... $100 product voucher each week during May to one winner. , “Whether the goal ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... East Los ... dental extractions. Currently, patients can visit Dr. Assili to receive any dental extraction treatment ... offer, and it expires June 30, 2016. With the lower price, patients can more ...
(Date:5/2/2016)... ... , ... Dr. Rassouli, dentist in Orange County, CA comments on ... which was published in the “Journal of the American Geriatrics Society,” more than a ... have Alzheimer’s disease. The study found that dental problems may increase the risk of ...
(Date:5/2/2016)... ... , ... Pregnancy Awareness Month offers a great time to get familiar with ... are ready to have a baby, it’s best to get started before age becomes ... Personal Conception & Pregnancy Organizer, written for women who plan on becoming pregnant to ...
(Date:5/2/2016)... ... 2016 , ... Dr. Jonathan Kulbersh of Carolina Facial Plastics isn’t surprised that Charlotte, NC, the ... of “ 5 US Cities with the Highest Plastic Rates .” The other cities ... results were calculated using a survey by RealSelf and combining that data with ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... TOKYO , April 28, 2016 ... and Ste phen ... ArisGlobal®, a leading provider of cloud-based software solutions for ... and Pharmacovigilance team to bring a wealth of insight to a ... unparalleled pharmacovigilance knowledge. George Phillips joined ArisGlobal ...
(Date:4/28/2016)... April 28, 2016 TapImmune,Inc. ... innovative peptide and gene-based immunotherapeutics and vaccines for the treatment ... presenting at the 3rd Annual Growth Capital Expo ... , 2016 at Caesars Palace in Las Vegas, Nevada.  ... Wednesday, May 4 th by Dr. John N. ...
(Date:4/27/2016)... 27 Avril 2016   ... de +5% sur le trimestre, soutenu par une ... Croissance de +16% des ventes aux ... Mauna Kea Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : MKEAY), ... annonce aujourd,hui son chiffre d,affaires pour le premier ...
Breaking Medicine Technology: