Navigation Links
Biologics Don't Raise Cancer Risk in Rheumatoid Arthritis Patients

Review finds no connection between drugs that block tumor necrosis factor and malignancies

TUESDAY, Oct. 28 (HealthDay News) -- TNF-antagonists, drugs widely used to treat rheumatoid arthritis (RA), don't appear to cause cancer, say Spanish researchers who analyzed data on more than 4,000 RA patients treated with the biologics.

These drugs, which have been used since 1998 and given to more than 600,000 people worldwide, interfere with biologic substances that cause or worsen inflammation in RA patients. But it's been unclear whether blocking TNF (tumor necrosis factor) increases the risk of cancer, according to background information in an American College of Rheumatology (ACR) news release about the study.

Some studies have suggested an association between RA and certain types of cancer, including lung and blood cancers, but the reasons for this increased risk are uncertain.

The data in this new study came from a drug registry called BIOBADASER, established in 2001 for long-term follow up of the safety of biological therapies in RA patients. The 4,529 RA patients treated with TNF-antagonists were compared with RA patients who didn't receive the drugs.

After they adjusted for age, sex, and RA duration/activity, the researchers found that the rate of cancer in the TNF group was very close to that of the non-TNF group (0.92 percent). Based on this, they concluded that TNF use isn't associated with an increased risk of developing cancer.

"Despite foreseen fears, blocking the tumor necrosis factor does not make patients more prone to develop cancer. All on the contrary, blocking the inflammation cascade may help diminish the overall risk of cancer in these patients," Dr. Loreto Carmona, director of the research unit at the Spanish Foundation of Rheumatology, said in the news release.

The study was presented Monday at the ACR annual meeting, in San Francisco.

More information

The U.S. Agency for Healthcare Research and Quality has more about medicines for rheumatoid arthritis.

-- Robert Preidt

SOURCE: American College of Rheumatology, news release, Oct. 25, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cell Therapeutics, Inc. (CTI) Plans to Submit Supplemental Biologics License Application (sBLA) for ZEVALIN(R) Consolidation of First Remission in Advanced Stage Follicular Lymphoma in 2008
2. CalbaTech Reports That LifeStems Biologics License Has Been Renewed
3. Nabi Biopharmaceuticals Completes Sale of Nabi Biologics to Biotest AG
4. Insmed to Present at the IBC 5th Annual Global Follow-On Biologics Conference
5. AstraZeneca - Biologics Day Interviews With Senior Management
6. In Post-Vioxx Era, Biologics are Reviving the Arthritis Treatment Market
7. Humira to Replace Remicade as First Choice Among Biologics for the Treatment of Crohns Disease
8. Growing Link Between Diabetes and Periodontal Disease Focus of National Gathering for Health Care Leaders
9. Treating your periodontal pockets may benefit your pocket book
10. Ortho Organizers(R) Announces the Launch of the Ancor Pro(TM) Orthodontic Anchorage System Hands-on Course
11. Survey confirms Americans prefer root canal treatment by endodontists
Post Your Comments:
Related Image:
Biologics Don't Raise Cancer Risk in Rheumatoid Arthritis Patients
(Date:12/1/2015)... ... December 01, 2015 , ... ... for the care management and population health arenas, is pleased to announce that ... cost containment services, has successfully implemented the ACUITY Complete Care™ Management to back ...
(Date:12/1/2015)... ... 2015 , ... With FCPX Overlay: Grit , users can apply a ... possibilities are truly endless, all with a click of a mouse. Each user has ... flip, depth of field and more, all within Final Cut Pro X. , With ...
(Date:12/1/2015)... ... December 01, 2015 , ... Tympani ... Technology Provider (ATP) status from Cisco. This designation recognizes Tympani as having fulfilled ... Contact Center solutions targeted to the high-end enterprise contact center marketplace. , Ed ...
(Date:11/30/2015)... ... December 01, 2015 , ... The Turks & Caicos Islands has enjoyed being ... news sites highlighting Caribbean destinations, has published five reasons to visit the Turks & ... shivers under chilly grey skies or worse, it's typically a balmy 80 degrees in ...
(Date:11/30/2015)... ... November 30, 2015 , ... 1Heart Caregiver Services’ ... the Federation of Philippine American Chambers of Commerce held from November 6-8, 2015 ... 1Heart Caregiver Services, as an active delegate from the Philippine American Chamber of ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... FRANCISCO , Nov. 30, 2015 Next ... Designers of Things (DoT ) co-located events covering ... and the Internet of Things, will draw more than ... Jose Convention Center. The events, combined show ... latest technologies. --> ...
(Date:11/30/2015)... Nov. 30, 2015   Royal Philips (NYSE: ... the industry,s first MRI guided user interface and automatic ... patients with MR Conditional implants, such as knee and ... 2015 Radiological Society of North America Annual Meeting (RSNA) ... supports diagnostic confidence of this growing patient population. ScanWise ...
(Date:11/30/2015)... 30, 2015 North America ... to grow at a CAGR of 7.6% from 2015 to 2020. ... USD 135.6 million in 2014, and is expected to grow at ... According to the new Market Research Report "North America Cardiac Output ... User (Hospitals, ambulatory care, others) - Analysis And Forecast To 2020", ...
Breaking Medicine Technology: