Navigation Links
Biological joints could replace artificial joints soon
Date:1/5/2011

Artificial joint replacements can drastically change a patient's quality of life. Painful, arthritic knees, shoulders and hips can be replaced with state-of-the-art metal or ceramic implants, eliminating pain and giving a person a new lease on life. But, what if, instead of metal and plastic, doctors were able to take a patient's cells and grow an entirely new joint, replacing the old one with a fully functional biological joint? A team of University of Missouri and Columbia University researchers have found a way to create these biological joints in animals, and they believe biological joint replacements for humans aren't far away.

In a study published this fall in The Lancet, James Cook, a researcher in the MU College of Veterinary Medicine and Dept of Orthopaedic Surgery participated on a research team that created new cartilage in animals using a biological "scaffold" in the animals' joints. Cook assisted with the implant design and performed the surgeries to implant the biologic joint replacements. The study was led by Jeremy Mao of Columbia University.

The scaffold was implanted in rabbits with a surgical technique currently used for shoulder replacement in humans. The surgery removes the entire humeral head, or the ball part of the ball-and-socket shoulder joints. The scaffolds are infused with a growth factor, which encourages the host's own cells, including stem cells, to become cartilage and bone cells. The advantage to this technique is that it avoids the need to harvest and implant cells, which requires multiple surgeries.

"The device was designed with both biological and mechanical factors in mind," Cook said. "It is unique in design and composition and in how it stimulates the body's own cells. This is the first time we have seen cartilage regeneration using this type of scaffold."

The study found that the rabbits given the infused scaffolds resumed weight-bearing and functional use of their limbs faster and more consistently than those without. Four months later, cartilage had formed in the scaffolds creating a new, functional cartilage surface for the humeral head. The team observed no complications or adverse events after surgery; the new tissue regeneration was associated with excellent limb use and shoulder health, indicating the procedure is both safe and effective. Cook, who also was involved in the study design and data analysis, said the next step toward FDA approval and clinical use is to study the technique in larger animals.

"If we continue to prove the safety and efficacy of this biologic joint replacement strategy, then we can get FDA approval for use of this technology for joint replacements in people," Cook said. "We are still in the early phases of this process, but this study gives a big boost to its feasibility."

"We are continuing our concerted efforts in this arena," Cook said. "Our goal at Mizzou's Comparative Orthopaedic Laboratory is to do away with metal and plastic joints, and instead, regenerate a fully functional biologic joint for everyone who needs one. We think this is the future of orthopaedics and we hope that future is starting here and now."


'/>"/>

Contact: Steven Adams
AdamsST@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Study carried out into biological risks of eating reptiles
2. Biological clock could be a key to better health, longer life
3. New method to grow arteries could lead to biological bypass for heart disease
4. U of T researchers crack splicing code, solve a mystery underlying biological complexity
5. Adolescent brains biologically wired to engage in risky behavior, study finds
6. Length of biological marker associated with risk of cancer
7. Ticking biological clock increases womens libido, new research shows
8. Researchers uncover biological rationale for why intensive lupus treatment works
9. Multifunctional nanoparticle enables new type of biological imaging
10. Biological changes in suicidal patients
11. University of Utah and Harvard researchers take major step toward first biological test for autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, ... today its affiliation with Tennessee Counseling Association. This new relationship allows ... the Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA is ...
(Date:6/27/2016)... NY (PRWEB) , ... June 27, 2016 , ... ... using cutting edge technology to revolutionize the emergency ambulance transport experience for the ... are aware of how Uber has disrupted the taxi industry through the use ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... Aliso Viejo, California (PRWEB) , ... June 26, 2016 , ... ... for Final Cut Pro X. , "Film editors can give their videos a whole ... artistically," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping ... fitness app. The fitness app plans to fix the two major problems leading the fitness ... size fits all type program , They don’t eliminate all the reasons people ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Bracket , a leading clinical trial technology and ... platform, Bracket eCOA (SM) 6.0, at the 52 nd ... 2016 in Philadelphia , Pennsylvania.  A demonstration ... of its kind to fully integrate with RTSM, will be ... is a flexible platform for electronic clinical outcomes assessments that ...
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... environments  Oticon , industry leaders in ... the launch of Oticon Opn ™, the world,s ... world of possibilities for IoT devices.      ... Opn, Oticon introduces a number of ,world firsts,: ...
Breaking Medicine Technology: