Navigation Links
Biological joints could replace artificial joints soon
Date:1/5/2011

Artificial joint replacements can drastically change a patient's quality of life. Painful, arthritic knees, shoulders and hips can be replaced with state-of-the-art metal or ceramic implants, eliminating pain and giving a person a new lease on life. But, what if, instead of metal and plastic, doctors were able to take a patient's cells and grow an entirely new joint, replacing the old one with a fully functional biological joint? A team of University of Missouri and Columbia University researchers have found a way to create these biological joints in animals, and they believe biological joint replacements for humans aren't far away.

In a study published this fall in The Lancet, James Cook, a researcher in the MU College of Veterinary Medicine and Dept of Orthopaedic Surgery participated on a research team that created new cartilage in animals using a biological "scaffold" in the animals' joints. Cook assisted with the implant design and performed the surgeries to implant the biologic joint replacements. The study was led by Jeremy Mao of Columbia University.

The scaffold was implanted in rabbits with a surgical technique currently used for shoulder replacement in humans. The surgery removes the entire humeral head, or the ball part of the ball-and-socket shoulder joints. The scaffolds are infused with a growth factor, which encourages the host's own cells, including stem cells, to become cartilage and bone cells. The advantage to this technique is that it avoids the need to harvest and implant cells, which requires multiple surgeries.

"The device was designed with both biological and mechanical factors in mind," Cook said. "It is unique in design and composition and in how it stimulates the body's own cells. This is the first time we have seen cartilage regeneration using this type of scaffold."

The study found that the rabbits given the infused scaffolds resumed weight-bearing and functional use of their limbs faster and more consistently than those without. Four months later, cartilage had formed in the scaffolds creating a new, functional cartilage surface for the humeral head. The team observed no complications or adverse events after surgery; the new tissue regeneration was associated with excellent limb use and shoulder health, indicating the procedure is both safe and effective. Cook, who also was involved in the study design and data analysis, said the next step toward FDA approval and clinical use is to study the technique in larger animals.

"If we continue to prove the safety and efficacy of this biologic joint replacement strategy, then we can get FDA approval for use of this technology for joint replacements in people," Cook said. "We are still in the early phases of this process, but this study gives a big boost to its feasibility."

"We are continuing our concerted efforts in this arena," Cook said. "Our goal at Mizzou's Comparative Orthopaedic Laboratory is to do away with metal and plastic joints, and instead, regenerate a fully functional biologic joint for everyone who needs one. We think this is the future of orthopaedics and we hope that future is starting here and now."


'/>"/>

Contact: Steven Adams
AdamsST@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Study carried out into biological risks of eating reptiles
2. Biological clock could be a key to better health, longer life
3. New method to grow arteries could lead to biological bypass for heart disease
4. U of T researchers crack splicing code, solve a mystery underlying biological complexity
5. Adolescent brains biologically wired to engage in risky behavior, study finds
6. Length of biological marker associated with risk of cancer
7. Ticking biological clock increases womens libido, new research shows
8. Researchers uncover biological rationale for why intensive lupus treatment works
9. Multifunctional nanoparticle enables new type of biological imaging
10. Biological changes in suicidal patients
11. University of Utah and Harvard researchers take major step toward first biological test for autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... Our bodies ... effective way to confront and deal with these stressors is to adopt a more ... be good for you. Risa Groux, a certified Holistic Nutritionist and the creator of ...
(Date:4/29/2016)... ... 2016 , ... Conditions were ideal for Global Lyme Alliance’s (GLA) 2nd annual ... skies, a light breeze and temperatures in the 60s. Over 400 runners, walkers and ... Walk and 1-mile walk were held to increase awareness about Lyme disease and ...
(Date:4/29/2016)... ... April 29, 2016 , ... Mobility Designed is redefining mobility with their ... the M+D Crutch evenly distributes body weight from the elbow to the forearm. ... the crutches than with other crutches. , Co-founders Max and Liliana Younger were inspired ...
(Date:4/29/2016)... ... April 29, 2016 , ... New York City based oral and maxillofacial surgeon Dr. ... very effective way to treat obstructive sleep apnea. Dr. Jamali is proud to offer this ... procedure that involves one or both jaw bones. This surgery is performed to correct the ...
(Date:4/29/2016)... ... , ... Regenerative Medicine Solutions (RMS) scored 94.8124 out of 100 ... second place for Tampa’s Best Places to Work. They were ranked in the Big ... accomplishment for our team,” says RMS Human Resources Manager Irene Miller. “We work hard ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 TapImmune,Inc. ... of innovative peptide and gene-based immunotherapeutics and vaccines for the ... be presenting at the 3rd Annual Growth Capital Expo ... th , 2016 at Caesars Palace in Las Vegas, Nevada.  ... on Wednesday, May 4 th by Dr. John ...
(Date:4/27/2016)...  Hologic, Inc. (Nasdaq: HOLX ) ... fiscal second quarter ended March 26, 2016.  GAAP ... 41.2%, and non-GAAP diluted EPS of $0.47 increased ... a reported basis, and 6.3% on a constant ... good quarter, highlighted by 14.6% growth in non-GAAP ...
(Date:4/27/2016)... le 27 Avril 2016 ... progressé de +5% sur le trimestre, soutenu par ... consommables  Croissance de +16% des ventes ... Mauna Kea Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : ... laser, annonce aujourd,hui son chiffre d,affaires pour le ...
Breaking Medicine Technology: