Navigation Links
Biological joints could replace artificial joints soon
Date:1/5/2011

Artificial joint replacements can drastically change a patient's quality of life. Painful, arthritic knees, shoulders and hips can be replaced with state-of-the-art metal or ceramic implants, eliminating pain and giving a person a new lease on life. But, what if, instead of metal and plastic, doctors were able to take a patient's cells and grow an entirely new joint, replacing the old one with a fully functional biological joint? A team of University of Missouri and Columbia University researchers have found a way to create these biological joints in animals, and they believe biological joint replacements for humans aren't far away.

In a study published this fall in The Lancet, James Cook, a researcher in the MU College of Veterinary Medicine and Dept of Orthopaedic Surgery participated on a research team that created new cartilage in animals using a biological "scaffold" in the animals' joints. Cook assisted with the implant design and performed the surgeries to implant the biologic joint replacements. The study was led by Jeremy Mao of Columbia University.

The scaffold was implanted in rabbits with a surgical technique currently used for shoulder replacement in humans. The surgery removes the entire humeral head, or the ball part of the ball-and-socket shoulder joints. The scaffolds are infused with a growth factor, which encourages the host's own cells, including stem cells, to become cartilage and bone cells. The advantage to this technique is that it avoids the need to harvest and implant cells, which requires multiple surgeries.

"The device was designed with both biological and mechanical factors in mind," Cook said. "It is unique in design and composition and in how it stimulates the body's own cells. This is the first time we have seen cartilage regeneration using this type of scaffold."

The study found that the rabbits given the infused scaffolds resumed weight-bearing and functional use of their limbs faster and more consistently than those without. Four months later, cartilage had formed in the scaffolds creating a new, functional cartilage surface for the humeral head. The team observed no complications or adverse events after surgery; the new tissue regeneration was associated with excellent limb use and shoulder health, indicating the procedure is both safe and effective. Cook, who also was involved in the study design and data analysis, said the next step toward FDA approval and clinical use is to study the technique in larger animals.

"If we continue to prove the safety and efficacy of this biologic joint replacement strategy, then we can get FDA approval for use of this technology for joint replacements in people," Cook said. "We are still in the early phases of this process, but this study gives a big boost to its feasibility."

"We are continuing our concerted efforts in this arena," Cook said. "Our goal at Mizzou's Comparative Orthopaedic Laboratory is to do away with metal and plastic joints, and instead, regenerate a fully functional biologic joint for everyone who needs one. We think this is the future of orthopaedics and we hope that future is starting here and now."


'/>"/>

Contact: Steven Adams
AdamsST@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Study carried out into biological risks of eating reptiles
2. Biological clock could be a key to better health, longer life
3. New method to grow arteries could lead to biological bypass for heart disease
4. U of T researchers crack splicing code, solve a mystery underlying biological complexity
5. Adolescent brains biologically wired to engage in risky behavior, study finds
6. Length of biological marker associated with risk of cancer
7. Ticking biological clock increases womens libido, new research shows
8. Researchers uncover biological rationale for why intensive lupus treatment works
9. Multifunctional nanoparticle enables new type of biological imaging
10. Biological changes in suicidal patients
11. University of Utah and Harvard researchers take major step toward first biological test for autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... VA (PRWEB) , ... March 28, 2017 , ... The ... Still, MHA, FRBMA, has begun to serve as its new executive director. Mr. Still ... the Executive Search Committee. , “Bob, as he is known to our members, ...
(Date:3/28/2017)... ... March 28, 2017 , ... Neurotechnology , ... biometric time and attendance tracking products: the new NCheck Cloud Bio Attendance cloud-based ... Attendance uses biometric face recognition to enable users to check in and out ...
(Date:3/28/2017)... St. Petersburg Florida (PRWEB) , ... March 28, 2017 , ... ... U.S. Marine Corp to raise money to for the Toys for Tots Literacy Campaign ... a federal budget in excess of $70 billion, the U.S. ranks at number 14 ...
(Date:3/28/2017)... ... March 28, 2017 , ... Prominant ... Surgical, Inc. is thrilled to offer the recently FDA-approved Obalon Balloon System to ... adds to SkyLex Advanced Surgical’s already comprehensive list of weight-loss services. Dr. ...
(Date:3/28/2017)... ... ... Silicon Valley Hair Institute, the San Francisco Bay Area leader in women's ... loss. Although hair transplant procedures can be seen as more of a man’s issue, ... two reasons a woman may see her hair thinning. , “We are used to ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... , March 28, 2017  Akcea Therapeutics, a subsidiary ... to the company,s board of directors: ... Partners. Mr. Gabrieli will serve as chairman of the board ... former chief commercial officer of Forest Laboratories. ... Biolink Partners. "We are excited to ...
(Date:3/28/2017)... 2017 RXi Pharmaceuticals Corporation (NASDAQ: RXII), ... address significant unmet medical needs, today announced that ... Patent Office (JPO) for the composition of matter ... for the treatment or prevention of fibrotic disorders, ... proliferative retinopathy (Japanese Patent #: 6060071).  This patent ...
(Date:3/28/2017)... , March 28, 2017  Medeon Biodesign, Inc., ... company, is pleased to announce that the Company ... of Panther Orthopedics, Inc., a San ... fixation solutions for orthopedic extremity applications.  ... expand rapidly, primarily due to procedure volume growth, ...
Breaking Medicine Technology: