Navigation Links
Biological catch-22 prevents induction of antibodies that block HIV
Date:12/15/2009

DURHAM, N.C. Scientists seeking to understand how to make an AIDS vaccine have found the cause of a major roadblock. It turns out that the immune system can indeed produce cells with the potential to manufacture powerful HIV-blocking antibodies but at the same time, the immune system works equally hard to make sure these cells are eliminated before they have a chance to mature.

"These studies show that a potentially protective neutralizing antibody against a viral disease is under the control of immunological tolerance," said Barton Haynes, M.D., director of the Center for HIV/AIDS Vaccine Immunology (CHAVI) at Duke University Medical Center and senior author of the study appearing in the online early edition of the Proceedings of the National Academy of Sciences. "This represents a new insight into the way HIV effectively evades detection by the B cell arm of the immune system and may offer new directions for vaccine design."

Over the years, scientists have assumed that B cells one of the first lines of defense against infection are simply not able to "see" the HIV virus. HIV has the ability to hide its most vulnerable parts from immune system surveillance, and researchers generally assumed that helped explain why B cells often took weeks and even months to arise following infection.

But several years ago, Duke researchers hypothesized that the antibodies required to broadly neutralize HIV may not be produced in the first place because the immune system "sees" them as a potential threat due to their similarity to antibodies that promote autoimmune disease and destroys them.

To see if this is indeed what happens, Laurent Verkoczy, Ph.D., assistant professor of medicine at Duke and the lead author of the study, and Haynes genetically engineered a mouse that could only produce B cells containing a rare but potent broadly neutralizing human antibody that is able to block HIV infection.

Researchers found
'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Thomson Scientific Announces BONDplus for Biological Researchers
2. Neurobiological Technologies Reports Going Concern Qualification
3. Neurobiological Technologies, Inc. Announces Receipt of Determination Letter from NASDAQ
4. Study questions assumptions about human sensitivity to biological motion
5. Neurobiological Technologies Reports $2.1 Million Quarterly Payment for Sales of Memantine
6. Neurobiological Technologies Announces Compliance With Nasdaq Listing Standards
7. Dr. Warren Wasiewski Appointed Chief Medical Officer of Neurobiological Technologies, Inc.
8. Biological markers of prostate cancer shed light on cancer burden faced by African-American men
9. Sanofi Pasteur Enters Agreement With Crucell for Next-Generation Biologicals Against Rabies
10. Biological Link Between BRCA1 and Breast Cancer Detailed
11. Boston IVF is First in Northeast to Offer Pioneering Test of Womens Biological Clock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... Las Vegas, NV (PRWEB) , ... September 02, ... ... Las Vegas and Fort Lauderdale, CENTURION SERVICE GROUP is internationally known as an ... largest medical auction house in the world, selling more than 100,000 pieces of ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... helping to bring awareness to International Overdose Awareness Day. The goal is to ... recognize the warning signs so that they may get help. , ...
(Date:9/2/2015)... ... 2015 , ... Please join the world renowned Brain Aneurysm ... established by the Foundation in 2007 with the help of Massachusetts State Representative ... remains our top priority,” commented Christine Buckley, Executive Director of the Brain Aneurysm ...
(Date:9/2/2015)... , ... September 02, 2015 , ... ... of Breast Cancer Awareness Month (BCAM), Bright Pink, a national non-profit focused on ... will launch Act On Facts, a campaign to educate women to be breast ...
(Date:9/1/2015)... ... September 01, 2015 , ... An August 25 ... of plastic surgeries conducted each year on teenagers, quoting a New York City-area ... Beverly Hills-based plastic surgeon Payam Jarrah-Nejad, M.D., F.I.C.S., F.A.C.S., known more familiarly to ...
Breaking Medicine News(10 mins):Health News:Over 1800 Lots of Surplus Used Medical Equipment 2Health News:Over 1800 Lots of Surplus Used Medical Equipment 3Health News:August 31 is International Overdose Awareness Day – Lakeview Health to Help Bring Awareness 2Health News:September Celebrated as Brain Aneurysm Awareness Month 2Health News:Bright Pink Launches Act On Facts™, A Campaign To Empower Young Women To Take Action Related To Their Breast And Ovarian Health 2Health News:Bright Pink Launches Act On Facts™, A Campaign To Empower Young Women To Take Action Related To Their Breast And Ovarian Health 3Health News:Teen Plastic Surgery Article Understates the Most Important Realities of Procedures on Young People, Notes Dr. J 2
... January 12, 2010 (BRONX, NY) Older women ... lesions that cause dementia later in life, according to ... The findings were published in the December 2009 online ... The research was conducted as part of the ...
... WINSTON-SALEM, N.C. A fast-acting compound that appears to ... found in patients with progressive Alzheimer,s disease has been ... Medicine and the Vanderbilt University Medical Center Program in ... result in humans. The compound benzylquinolone carboxylic ...
... ... Molecular Medicine. Molecular Medicine publishes research concerned with the pathogenesis of disease at the ... prevention. , ... January 12, 2010 -- By the time a person experiences symptoms of an aggressive ...
... , DETROIT , Jan. 12 ... Board of Directors has set the date for the Company,s Annual Meeting ... vote at the meeting.   , The Annual Shareholders, Meeting will be ... EST at the MGM Grand Hotel, 1777 Third Street in ...
... hospice and preferred place of death are often needed, experts ... patients have much to consider, from whether they want to ... want doctors to continue aggressive treatment or focus on making ... those difficult, emotional conversations aren,t happening nearly as often, or ...
... WASHINGTON , Jan. 12 The American Lung ... report, which grades the strength of federal and state ... at the heart of America,s chronic disease crisis. , The ... still has significant room for progress. Most state governments , ...
Cached Medicine News:Health News:Hypertension linked to dementia in older women 2Health News:Hypertension linked to dementia in older women 3Health News:New compound improves cognitive decline, symptoms of Alzheimer's disease in rodents 2Health News:New compound improves cognitive decline, symptoms of Alzheimer's disease in rodents 3Health News:News from the Latest Issue of Molecular Medicine 2Health News:United American Healthcare Corporation Announces Meeting Date and Record Date for Annual Meeting of Shareholders 2Health News:United American Healthcare Corporation Announces Meeting Date and Record Date for Annual Meeting of Shareholders 3Health News:Doctors Put Off End-of-Life Talks With Terminally Ill 2Health News:Doctors Put Off End-of-Life Talks With Terminally Ill 3Health News:American Lung Association Report Card: Federal Government Makes Major Strides; Most States Flunk for Neglecting to Prevent Tobacco-Caused Disease 2Health News:American Lung Association Report Card: Federal Government Makes Major Strides; Most States Flunk for Neglecting to Prevent Tobacco-Caused Disease 3Health News:American Lung Association Report Card: Federal Government Makes Major Strides; Most States Flunk for Neglecting to Prevent Tobacco-Caused Disease 4Health News:American Lung Association Report Card: Federal Government Makes Major Strides; Most States Flunk for Neglecting to Prevent Tobacco-Caused Disease 5Health News:American Lung Association Report Card: Federal Government Makes Major Strides; Most States Flunk for Neglecting to Prevent Tobacco-Caused Disease 6Health News:American Lung Association Report Card: Federal Government Makes Major Strides; Most States Flunk for Neglecting to Prevent Tobacco-Caused Disease 7Health News:American Lung Association Report Card: Federal Government Makes Major Strides; Most States Flunk for Neglecting to Prevent Tobacco-Caused Disease 8
(Date:9/2/2015)... MENLO PARK, Calif. , Sept. 2, 2015 ... company today announced that Jim Pekarsky , chief executive ... & Renshaw 17th Annual Global Investment Conference taking place, September ... York . Mr. Pekarsky is scheduled to ... in Astor Suite A (2 nd floor). ...
(Date:9/2/2015)... MENLO PARK, Calif. , Sept. 2, ... DMPI) ("DelMar" and the "Company"), a biopharmaceutical company ... cancer therapies, today announced that it will present ... Mechanisms and Cytotoxic Activity of Dianhydrogalactitol (VAL-083) to ... Mutant p53," at the American Association for ...
(Date:9/2/2015)... , Sep. 02, 2015 ... announced the addition of the "Pharmaceutical Regulatory ... - October 18-19, 2015)" conference to their ... Compliance with Regulatory Requirements Particularly relevant ... and Document Management Functions & Regulatory Authorities ...
Breaking Medicine Technology:DelMar Pharmaceuticals Announces Expansion of VAL-083 Development Program to Include Ovarian Cancer 2DelMar Pharmaceuticals Announces Expansion of VAL-083 Development Program to Include Ovarian Cancer 3DelMar Pharmaceuticals Announces Expansion of VAL-083 Development Program to Include Ovarian Cancer 4Pharmaceutical Regulatory Affairs Course in the Middle East, Dubai (Dubai, UAE - October 18-19, 2015) 2
... in CA, FL, IN, ME, NC, NY, SC, VT ... and enhance,prevention, self-management of health conditions, PRINCETON, N.J., ... today during a telenews conference the,first round of grants ... $2 million in grants will enable 12 research teams ...
... First, Pivotal Study on a New Antiviral CMV Therapy in Stem Cell Transplant in ... Over a Decade -, - ... ... Incorporated,(Nasdaq: VPHM ) today announced that it completed enrollment in its pivotal,Phase 3 study of ...
Cached Medicine Technology:Discovering How Video Games Can Motivate Healthy Behaviors: More than $2 Million Awarded to 12 Research Teams Across U.S. 2Discovering How Video Games Can Motivate Healthy Behaviors: More than $2 Million Awarded to 12 Research Teams Across U.S. 3Discovering How Video Games Can Motivate Healthy Behaviors: More than $2 Million Awarded to 12 Research Teams Across U.S. 4Discovering How Video Games Can Motivate Healthy Behaviors: More than $2 Million Awarded to 12 Research Teams Across U.S. 5Discovering How Video Games Can Motivate Healthy Behaviors: More than $2 Million Awarded to 12 Research Teams Across U.S. 6Discovering How Video Games Can Motivate Healthy Behaviors: More than $2 Million Awarded to 12 Research Teams Across U.S. 7Discovering How Video Games Can Motivate Healthy Behaviors: More than $2 Million Awarded to 12 Research Teams Across U.S. 8ViroPharma Announces Completion of Enrollment in Phase 3 Study of Maribavir in Stem Cell Transplant Patients 2ViroPharma Announces Completion of Enrollment in Phase 3 Study of Maribavir in Stem Cell Transplant Patients 3ViroPharma Announces Completion of Enrollment in Phase 3 Study of Maribavir in Stem Cell Transplant Patients 4ViroPharma Announces Completion of Enrollment in Phase 3 Study of Maribavir in Stem Cell Transplant Patients 5ViroPharma Announces Completion of Enrollment in Phase 3 Study of Maribavir in Stem Cell Transplant Patients 6
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: