Navigation Links
Biological FM signal maintains inflammation in cancer, asthma and other diseases
Date:4/9/2009

A study published tomorrow (10 April) in Science examines a key player in conditions such as cancer, inflammatory bowel disease, rheumatoid arthritis and asthma and has shown that cells use a sophisticated communication system to coordinate responses to infection and maintain inflammation in the body. This system is now a target for designing drugs to treat these conditions.

Scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC), the Medical Research Council (MRC) and the Engineering and Physical Sciences Research Council (EPSRC) have combined biological experiments and mathematics to discover the secrets of NF-kappaB a biological machine that coordinates the setting up and maintenance of inflammation in the body by broadcasting a signal to surrounding cells.

The team from the Universities of Liverpool, Manchester and Warwick, along with scientists from pharmaceutical company AstraZeneca (AstraZeneca R & D, Charnwood) have used Systems biology a multidisciplinary approach that uses a combination of experimental and theoretical techniques to tackle biological problems to investigate the role of NF-kappaB.

Professor Michael White of the University of Liverpool, who led the research said: "We know that successive peaks and troughs in the amount of NF-kappaB forming a wave-like pattern over time can exert exquisite control over many biological processes that underlie the symptoms of inflammation. Furthermore, what we now see is that different cell processes are determined once they pick up the frequency of peaks and troughs in the NF-kappaB signal, just like tuning in to an FM radio signal."

Professor Douglas Kell, BBSRC Chief Executive and co-author of the paper in his previous role added: "This research is an example that shows truly integrated systems biology allowing us to get right to the bottom of a complex and important biological question i.e. can we better understand the fundamental biology of inflammation in order to treat disease?

"The results of our work simultaneously aid and challenge drug designers; it will not simply be a matter of using a drug to knock down one key biological player in an inflammatory disease. This research tells us that cells in inflammatory tissues may use very precise timing to communicate between each other in order to determine the overall response to infection and the extent to which inflammation is maintained. Systems biology is enabling us to get a complete picture of the biology underpinning inflammation and thus pinpoint the potential axes of control that might be targeted with drugs."


'/>"/>

Contact: Nancy Mendoza
press.office@bbsrc.ac.uk
01-793-413-355
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Related medicine news :

1. Thomson Scientific Announces BONDplus for Biological Researchers
2. Neurobiological Technologies Reports Going Concern Qualification
3. Neurobiological Technologies, Inc. Announces Receipt of Determination Letter from NASDAQ
4. Study questions assumptions about human sensitivity to biological motion
5. Neurobiological Technologies Reports $2.1 Million Quarterly Payment for Sales of Memantine
6. Neurobiological Technologies Announces Compliance With Nasdaq Listing Standards
7. Dr. Warren Wasiewski Appointed Chief Medical Officer of Neurobiological Technologies, Inc.
8. Biological markers of prostate cancer shed light on cancer burden faced by African-American men
9. Sanofi Pasteur Enters Agreement With Crucell for Next-Generation Biologicals Against Rabies
10. Biological Link Between BRCA1 and Breast Cancer Detailed
11. Boston IVF is First in Northeast to Offer Pioneering Test of Womens Biological Clock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... The Aesthetic Channel has recently highlighted Dr. Ben ... up with a proprietary technique that he calls the AuraLyft Facelift. The ... all ages, patients can expect to look refreshed, rejuvenated, and revitalized. , Dr. ...
(Date:6/23/2017)... ... June 23, 2017 , ... 21 Middle East and South Asia Leaders ... leaders from government, business and civil society in 11 countries across the Middle East ... engaging in a transformative exchange of knowledge and ideas with the leading minds in ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ross ... offerings. With the Federal Emergency Management Agency’s (FEMA) recent update of flood zones, ... In 2012, the Biggert-Waters Act was enacted to reflect the actual risk in ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Katyl Agency, a ... families and business owners in and around Lackawanna County, is joining Meals On ... the area. , Meals on Wheels of NEPA provides hand-delivered and nutritious meals ...
(Date:6/23/2017)... ... June 23, 2017 , ... Radabaugh & ... to families and business owners in North Central West Virginia, is embarking on ... to differently abled residents in the region. , The Stepping Stones organization offers ...
Breaking Medicine News(10 mins):
(Date:6/8/2017)... , June 8, 2017   Responding to Heath ... and the death of singer Chris Cornell in ... Rights International offers a free online psychiatric ... consumers and families about psychotropic drug risks. ... who died from an accidental overdose, has called for tighter ...
(Date:6/5/2017)... , June 5, 2017 The Cincinnati ... of Diplomat Pharmacy, Inc. (NYSE: DPLO), has been awarded a ... Enquirer . Results are based on an employee ... organizational health and workplace improvement. The survey measures several aspects ... ...
(Date:5/30/2017)... , May 30, 2017 DarioHealth Corp. (NASDAQ: DRIO), ... data solutions, today announced that it will be presenting at the ... 8:00 AM PT. Erez Raphael , CEO, of DarioHealth will ... conference will be held on June 6th & 7th, 2017 at ... in the small / micro-cap space. ...
Breaking Medicine Technology: