Navigation Links
Biological FM signal maintains inflammation in cancer, asthma and other diseases

A study published tomorrow (10 April) in Science examines a key player in conditions such as cancer, inflammatory bowel disease, rheumatoid arthritis and asthma and has shown that cells use a sophisticated communication system to coordinate responses to infection and maintain inflammation in the body. This system is now a target for designing drugs to treat these conditions.

Scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC), the Medical Research Council (MRC) and the Engineering and Physical Sciences Research Council (EPSRC) have combined biological experiments and mathematics to discover the secrets of NF-kappaB a biological machine that coordinates the setting up and maintenance of inflammation in the body by broadcasting a signal to surrounding cells.

The team from the Universities of Liverpool, Manchester and Warwick, along with scientists from pharmaceutical company AstraZeneca (AstraZeneca R & D, Charnwood) have used Systems biology a multidisciplinary approach that uses a combination of experimental and theoretical techniques to tackle biological problems to investigate the role of NF-kappaB.

Professor Michael White of the University of Liverpool, who led the research said: "We know that successive peaks and troughs in the amount of NF-kappaB forming a wave-like pattern over time can exert exquisite control over many biological processes that underlie the symptoms of inflammation. Furthermore, what we now see is that different cell processes are determined once they pick up the frequency of peaks and troughs in the NF-kappaB signal, just like tuning in to an FM radio signal."

Professor Douglas Kell, BBSRC Chief Executive and co-author of the paper in his previous role added: "This research is an example that shows truly integrated systems biology allowing us to get right to the bottom of a complex and important biological question i.e. can we better understand the fundamental biology of inflammation in order to treat disease?

"The results of our work simultaneously aid and challenge drug designers; it will not simply be a matter of using a drug to knock down one key biological player in an inflammatory disease. This research tells us that cells in inflammatory tissues may use very precise timing to communicate between each other in order to determine the overall response to infection and the extent to which inflammation is maintained. Systems biology is enabling us to get a complete picture of the biology underpinning inflammation and thus pinpoint the potential axes of control that might be targeted with drugs."


Contact: Nancy Mendoza
Biotechnology and Biological Sciences Research Council

Related medicine news :

1. Thomson Scientific Announces BONDplus for Biological Researchers
2. Neurobiological Technologies Reports Going Concern Qualification
3. Neurobiological Technologies, Inc. Announces Receipt of Determination Letter from NASDAQ
4. Study questions assumptions about human sensitivity to biological motion
5. Neurobiological Technologies Reports $2.1 Million Quarterly Payment for Sales of Memantine
6. Neurobiological Technologies Announces Compliance With Nasdaq Listing Standards
7. Dr. Warren Wasiewski Appointed Chief Medical Officer of Neurobiological Technologies, Inc.
8. Biological markers of prostate cancer shed light on cancer burden faced by African-American men
9. Sanofi Pasteur Enters Agreement With Crucell for Next-Generation Biologicals Against Rabies
10. Biological Link Between BRCA1 and Breast Cancer Detailed
11. Boston IVF is First in Northeast to Offer Pioneering Test of Womens Biological Clock
Post Your Comments:
(Date:11/26/2015)... ... November 26, 2015 , ... Patients at Serenity ... have come together on Thanksgiving Day to share the things that they are ... the Serenity Point YouTube channel, patients displayed what they wrote on index cards, ...
(Date:11/26/2015)... ... November 26, 2015 , ... CognisantMD and ... diagnostic imaging in the Waterloo region. Using the Ocean Platform, family physicians can ... from their electronic medical record (EMR) without the need for redundant patient entry ...
(Date:11/26/2015)... ... 2015 , ... The Catalent Applied Drug Delivery Institute today ... dose form selection in early phase drug development. The first of these is ... together the UK’s emerging life sciences companies, corporate partners, and investors, at Milton ...
(Date:11/26/2015)... , ... November 26, 2015 , ... PRMA Plastic Surgery ... 19, 2015, our surgeons performed their 6,000th free flap breast reconstruction surgery! , “What ... up every day excited to rebuild lives and it’s an honor to have served ...
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... ... new set of retro-fused, self-animating trailer titles with ProTrailer: Vintage. This newly styled ... These classically-influenced trailer titles work with any font, giving users limitless opportunities to ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... Ein neuer Kombinationsansatz vereint ... --> Ein neuer Kombinationsansatz vereint Immuntherapie ... --> Ein neuer Kombinationsansatz vereint Immuntherapie ... Clinical Cancer Research vom 6. November ... vom 6. November 2015 berichtet. --> ...
(Date:11/27/2015)... Nov. 26, 2015 ... of the "2016 Global Tumor Marker ... Volume and Sales Segment Forecasts, Innovative Technologies, ... report to their offering. --> ... the "2016 Global Tumor Marker Testing ...
(Date:11/26/2015)... Carolina , 26 november 2015 /PRNewswire/ ... (AAIPharma/CML) kondigt de geplande investering aan van ... van de laboratoria en het mondiale hoofdkantoor ... De uitbreiding zal resulteren in extra kantoorruimte ... voldaan aan de groeiende behoeften van de ...
Breaking Medicine Technology: