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Biologic Joint Reconstruction Using Stem Cells Proven Successful In Patients With Arthritis
Date:3/23/2010

es more than the duration of this study for malalignment to produce negative effects on cartilage, but it also suggests that an osteotomy or angle correction of the leg may not be necessary to have good pain relief if the meniscus is replaced,” said Dr. Stone.

Increased age and increased number of previous surgeries increased the risk of failure but only slightly. Sixty six patients were younger than 50 years old at time of surgery, with an average age of 39 years. Fifty three patients were older than 50 years old at time of surgery with an average age of 56 years. Average procedure survival time for a 39 year old patient was calculated at 10.7 years; for a 56 year old patient it was calculated at 8.8 years. “Even with the effect of age, telling a 56 year old that meniscus allograft transplantation is predicted to last an average of 8.8 years is clinically significant. Most of my older patients are interested in buying time, continuing to play sports and delaying artificial joint replacement,” said Dr. Stone.

The 18 cases in the study that did progress to artificial joint replacement did so at average time of 4.8 years after meniscus allograft transplantation. Average age at time of subsequent knee arthroplasty was 60.9 years (range: 52.1 – 72.2 yrs). “With the increasing costs of primary and revision artificial joint replacement, the economic impact of delaying primary knee arthroplasty using an outpatient arthroscopic procedure for even 5 years is of interest,” said Dr. Stone.

Articular cartilage paste grafting, which combines an extensive marrow stimulating technique with stem cells, cartilage and bone grafting for articular cartilage repair was used in 56.3% of cases for treatment of severe articular cartilage damage at the time of meniscus allograft trans
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