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Biologic Joint Reconstruction Using Stem Cells Proven Successful In Patients With Arthritis
Date:3/23/2010

alidated subjective outcomes assessments before surgery and then at 2, 3, 5, 7, 10, and 12 years after surgery. Significant improvements in pain, activity, and function were found over the course of follow-up; indicating that patients improve significantly within the first 2 years after surgery and that these improvements are maintained over time.

Kaplan-Meier survival analysis calculated average procedure survival time at 9.93 years. This study is unique because severe articular cartilage damage is often considered a contraindication for meniscus allograft transplantation. However in the study procedures, arthritic cartilage was repaired often with a stem cell repair technique called paste grafting. In the repair technique, stem cells, bone and cartilage from the patients knee are removed and combined into a paste and then grafted onto the damaged area at the same time as replacement of the meniscus cartilage with a donor tissue from a cadaver.

Procedure failure was defined as progression to artificial joint replacement, or removal of the meniscus allograft without revision. Revision meniscus allograft transplantation was carried out in 8 cases (6.7%); only one of these cases ultimately failed. Twenty-five of the 119 meniscus allograft transplantations failed (20.1%) with a mean failure time of 4.65 years (range, 2.1 months - 10.37 years). The Cox proportional hazards model was used to evaluate the relationship between procedure failure and many factors. Medial versus lateral allograft, degree of joint space narrowing, malalignment, and gender had no significant effect on risk of failure.

Malalignment – being excessively knock-kneed or bowlegged – is a common contraindication for meniscus allograft transplantation. Alignment did not affect outcome in this study. “It may be that it tak
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