Navigation Links
Bioinformatics approach helps researchers find new uses for old drug
Date:5/5/2014

BOSTON -- Developing and testing a new anti-cancer drug can cost billions of dollars and take many years of research. Finding an effective anti-cancer medication from the pool of drugs already approved for the treatment of other medical conditions could cut a considerable amount of time and money from the process.

Now, using a novel bioinformatics approach, a team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) has found that the approved antimicrobial drug pentamidine may help in the treatment of patients with advanced kidney cancer. Described online in the journal Molecular Cancer Therapeutics, the discovery reveals how linking cancer gene expression patterns with drug activity might help advance cancer care.

"The strategy of repurposing drugs that are currently being used for other indications is of significant interest to the medical community as well as the pharmaceutical and biotech industries," says senior author Towia Libermann, PhD, Director of the Genomics, Proteomics, Bioinformatics and Systems Biology Center at BIDMC and Associate Professor of Medicine at Harvard Medical School. "Our results demonstrate that bioinformatics approaches involving the analysis and matching of cancer and drug gene signatures can indeed help us identify new candidate cancer therapeutics."

Renal cell cancer consists of multiple subtypes that are likely caused by different genetic mutations. Over the years, Libermann has been working to identify new disease markers and therapeutic targets through gene expression signatures of renal cell cancer that distinguish these different cancer subtypes from each other, as well as from healthy individuals. In this new paper, he and his colleagues were looking for drugs that might be effective against clear cell renal cancer, the most common and highly malignant subtype of kidney cancer. Although patients with early stage disease can often be successfully treated through surgery,
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Bioinformatics experts at the CNIO explore additional coding potential hidden in the human genome
2. North America Leads the Largest Market Share of the Bioinformatics Market Says New Research Report by MarketsandMarkets
3. Bioinformatics Market (Molecular Medicine, Agriculture, Research & Forensic) worth $7.5 Billion by 2017 - New Report by MarketsandMarkets
4. Global Bioinformatics Market - Industry Size, Market Share, Trends, Analysis And Forecast 2013 - 2019
5. Global Bioinformatics Market 2014-2018 Industry size, Shares, Research Trends, Growth, Study, Analysis, Forecast
6. Bioinformatics profiling identifies a new mammalian clock gene
7. Unique approach needed to accurately assess health of young adult cancer survivors
8. MU receives national award for using mind-body approach to improve health
9. Global, common approach to pharmaceutical supply chain integrity the focus of workshop
10. Editorial calls for comprehensive approach to cancer screening
11. Rutgers team discovers novel approach to stimulate immune cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Technology Association of Georgia in collaboration with ... Social Savvy Awards this week at a special ceremony ... in Downtown Atlanta. The event celebrates Georgia’s best and ... honored with the 2014 TAG Social Savvy People’s Choice ... in 6 other award categories: , , ...
(Date:9/18/2014)... (HealthDay News) -- Teens and young adults who,ve been ... that provides them with greater responsibility and independence early ... "We found that having a mentor provides a ... lead author, Steve McDonald, an associate professor of sociology ... news release. In conducting the study, published ...
(Date:9/18/2014)... Research led by Paulo Rodriguez, PhD, an assistant ... Health New Orleans, Stanley S. Scott Cancer Center, has ... Chop plays in the body,s ability to fight cancer. ... the activity and accumulation of cells that suppress the ... Orleans research team showed that when they removed Chop, ...
(Date:9/18/2014)... The Spartan race is known as ... course lengths of 3+miles (Sprint), 8+miles, (Super) and 12+miles ... signature obstacles designed to help participants discover their inner ... a Spartan Race and the feeling of accomplishment that ... and accept people of all ages, backgrounds, and fitness ...
(Date:9/18/2014)... September 18, 2014 Activz ... to announce the release of Activz Coconut Water ... liquid of young, organic coconuts from Thailand. Activz Coconut ... Activz Whole-Food Nutrition revolutionary line of produce powders available ... options. The new Activz Coconut Water Powder will ...
Breaking Medicine News(10 mins):Health News:Winners Honored at 2014 TAG Social Savvy Awards 2Health News:Winners Honored at 2014 TAG Social Savvy Awards 3Health News: Mentors May Steer Young People Toward More Rewarding Careers 2Health News:LSU Health research discovers means to free immune system to destroy cancer 2Health News:A Marine Corps Combat Veteran Teams Up with Spartan Races to Ease the Pain and Speed Up Recovery of Spartan Race Warriors with Topricin Pain Relief and Healing Creams 2Health News:A Marine Corps Combat Veteran Teams Up with Spartan Races to Ease the Pain and Speed Up Recovery of Spartan Race Warriors with Topricin Pain Relief and Healing Creams 3Health News:A Marine Corps Combat Veteran Teams Up with Spartan Races to Ease the Pain and Speed Up Recovery of Spartan Race Warriors with Topricin Pain Relief and Healing Creams 4Health News:New Activz Organic Coconut Water Powder Announced at Natural Products Expo East 2Health News:New Activz Organic Coconut Water Powder Announced at Natural Products Expo East 3
... BRANFORD, Conn., Sept. 5 CuraGen Corporation,(Nasdaq: CRGN ... that Dr. Frank M. Armstrong, President and Chief,Executive Officer, ... Bear,Stearns 20th Annual Healthcare Conference on Tuesday, September 11, ... held at The Grand Hyatt,New York in New York ...
... Va., Sept. 5 Traditional Latin,American foods have a ... foods that have brought families together for generations are,being ... Oftentimes Latin foods are prepared with high-calorie ingredients ... to the American Diabetes,Association (ADA), eating foods high in ...
... the Canadian Institutes of Health Research (CIHR) unveiled a ... of research it has funded. CIHR will require its ... freely available online within six months of publication. ... is a defining feature of science, and is essential ...
... PHOENIX, Sept. 4 TriWest Healthcare Alliance is,offering an ... have lost a loved one in service to our ... unit commanders, TriWest is partnering,with noted author and nationally ... killed in the line of duty. Through a ...
... MINNEAPOLIS, Sept. 4 HEI, Inc. (Nasdaq: HEII,-- ... closed on the sale of,substantially all of the ... Inc., a wholly-owned subsidiary of Dutch based Smartrac ... substantially all the assets of the,RFID division, including ...
... Brings Over 20 Years Of Experience ... in Sales, Marketing And Operational Excellence, LENEXA, Kan., ... ) announced the appointment of Thomas Kelly,Mann as chief ... than 20 years with 3M,s healthcare information technology,division where ...
Cached Medicine News:Health News:CuraGen to Present at the Bear Stearns 20th Annual Healthcare Conference 2Health News:Top Tips to Enjoy Healthy Latin Food Without Losing the Taste (Recipe) 2Health News:Top Tips to Enjoy Healthy Latin Food Without Losing the Taste (Recipe) 3Health News:Open access to health research publications 2Health News:TriWest Creates First-of-its-Kind Partnership to Offer Military Leaders With Grief Support Program 2Health News:HEI, Inc. Closes on Sale of RFID Division Assets 2Health News:Mediware Names Thomas K. Mann Chief Executive Officer 2
(Date:9/18/2014)... 2014  Halozyme Therapeutics, Inc. (NASDAQ: ... and Drug Administration (FDA) has removed the clinical ... in SWOG,s ongoing Phase 1b/2 clinical trial (S1313). ... drug PEGPH20 (PEGylated Recombinant Human Hyaluronidase) in combination ... metastatic pancreatic adenocarcinoma.  The study will resume under ...
(Date:9/18/2014)... , Sept. 18, 2014 Veterinary biologic ... Dr. Ashraf Hanna , M.D., Ph.D., and Dr. ... of Directors. Dr. Hanna is the Vice President of ... Financial Officer for the Genentech Foundation, while Dr. McCracken ... of Business Development and Licensing for Roche Pharma. ...
(Date:9/18/2014)... , Sept. 18, 2014 Australian biomarker discovery ... US trial of its MiStat™ prostate cancer screening test, ... regulatory approval upon completion. Minomic,s proprietary MiStat™ ... presence of a proprietary biomarker known as the MIL-38 ... prostate cancer cells. Researchers at 11 ...
Breaking Medicine Technology:SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 2SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 3SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 4Nexvet Appoints Ashraf Hanna and Joseph McCracken to Board of Directors 2Nexvet Appoints Ashraf Hanna and Joseph McCracken to Board of Directors 3Minomic Launches US Pilot Study of MiStat(TM) Novel Prostate Cancer Screening Technology 2
... , NEW BRUNSWICK, N.J., Nov. 12 Senesco ... SNT ) announced today that Catherine Taylor, ... presenting pre-clinical stability and biological activity data on ... 2009 American Association for Cancer Research (AACR)-National Cancer ...
... Thoratec Corporation (Nasdaq: THOR ), a world leader ... and restore failing hearts, said today that it will ... HeartMate II Destination Therapy clinical trial that will be ... the American Heart Association(AHA) Scientific Sessions 2009. , The ...
Cached Medicine Technology:Senesco Presents Pre-Clinical Stability and Biological Activity Data on SNS-01 at the 2009 AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics Conference 2Senesco Presents Pre-Clinical Stability and Biological Activity Data on SNS-01 at the 2009 AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics Conference 3
Stainless steel flexible ruler. graduated in 1/32 inches (.8 mm) fractions, as well as mm graduations....
Designed to determine the precise length of limbal incisions and proper alignment of closing sutures. Curved marking blade with 2 mm lines spaced 1 mm apart-measures up to 10 mm. Round knurled handle...
Measures up to 152 mm in 1 mm increments and 6 inches in 1/32 inch increments. Deeply etched graduations and dull finish....
Rigid Endoscopes....
Medicine Products: