Navigation Links
Biogen Idec's baminercept alfa shows promise in patients with rheumatoid arthritis
Date:6/12/2008

ata Results

The Phase IIa blinded, multicenter, placebo-controlled trial was designed to assess the safety, pharmacokinetics, pharmacodynamics and efficacy of baminercept with methotrexate, a standard RA therapy, at different dose ranges. Patients (n=47) were randomized in a dose-escalating fashion to receive placebo or one of six doses of baminercept, ranging from 0.01 mg/kg to 3.0 mg/kg once weekly for four weeks, followed by eight weeks of observation. Patients had to have received methotrexate for at least three months prior to enrollment and continued to receive a stable dose of methotrexate throughout the study period.

Study results suggested improvement in the majority of ACR core set measurements (a series of standard measurement criteria for RA symptom and disease improvement) in patients given baminercept compared with placebo. At day 35, patients given baminercept showed an average 60 percent improvement from baseline in swollen joint count and 47 percent improvement in tender joint count, compared with 4.6 percent and 6.7 percent with placebo, respectively. Improvements in these ACR measures persisted for eight weeks after the final baminercept dose. Similar levels of improvements were observed at day 35 in several other standard markers of inflammation and disease progression. ACR scores and other measures improved in a dose dependent manner, with the greatest improvements reported in the groups receiving 1.0 mg/kg and 3.0 mg/kg.

The most common adverse event in patients receiving baminercept was headache. Transient mild-to-moderate flu-like symptoms were observed in 9 patients (25 percent) within 24 hours after the first dose of baminercept. However, these symptoms responded well to paracetamol (acetaminophen) and tended not to recur with subsequent doses. No serious, drug-related adverse events were reported in this study.

Based on the results of the Phase IIa study, Biogen Idec has initiated two Phase II
'/>"/>

Contact: Rachi Govil
rachi.govil@offspringpr.com
212-798-9827
Offspring PR
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Broad Stakeholder Coalition Concludes that the Pathway for Biosimilars Act Fails to Ensure Timely Access to Safe, Affordable Biogeneric Medicines for Patients
2. New MedPAC Report: Abbreviated Biogenerics Pathway Urgently Needed
3. PCMA 2008 Agenda: Support E-Prescribing, Biogenerics; Oppose Bills that Increase Costs
4. Cell Therapeutics, Inc. (CTI) Completes Acquisition of Lymphoma Drug Zevalin(R) From Biogen Idec for Sales and Marketing in the United States
5. New Bird Flu Vaccine Shows Promise
6. New research shows room for improvement in health news
7. Opting out revolution a myth: Study shows steep employment gains for women, mothers
8. New KLRI Reports Shows Longevity Science Moving Beyond Studying the Obvious to the Downward Spiral Paradigm in the Aging Process
9. New Treatment Shows Promise for Excessive Drinking
10. New Heart Ultrasound Research Shows Hope for Diagnosing and Treating Fatal Heart Conditions
11. Blood Cancer Drug Shows Promise Against Lupus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... NAPW honors Michelle ... the Year. Ms. Foley is recognized with this prestigious ... networking organization of professional women in the country, spanning ... Professional Women is a powerfully vibrant networking community with ... “As a nurse, I felt like I made a ...
(Date:12/22/2014)... Parker & Sons, Inc. a reliable and ... contracting services reports a record number of favorable reviews ... 2014. As a company that has served the greater ... Sons is a business that is focused on excellent ... other top quality companies in Arizona that are focused ...
(Date:12/21/2014)... Hills, Ca (PRWEB) December 21, 2014 ... Khanna was a guest at the Aspen Helicopters holiday ... kids and a Santa with sleigh, flown by an ... helicopter appeared invisible; only Santa with sleigh was visible.(please ... during day and night. Dr.Khanna has helped many pilots ...
(Date:12/21/2014)... Recently, one of the best prom dresses online shops ... introduced its new collection of 2015 prom dresses, and ... its prom dresses & other fashionable designs, up to ... quality dress products and great customer services to its ... the best prom dresses online shops around the world ...
(Date:12/21/2014)... CA (PRWEB) December 21, 2014 Over ... resolved performance issues in hundreds of emergency departments across ... satisfaction. Its findings have been translated into an innovative ... leaders to correct deficiencies and enhance the patient experience. ... outsourced emergency physician staffing and management services for hospitals, ...
Breaking Medicine News(10 mins):Health News:National Association of Professional Women Announces Michelle M. Foley, Vice President of Operations of OTTR Chronic Care Solutions, a 2014 Professional Woman of the Year 2Health News:Parker & Sons Reports A Record Number Of Favorable References With Regard To Its Quality Services In 2014 2Health News:Parker & Sons Reports A Record Number Of Favorable References With Regard To Its Quality Services In 2014 3Health News:New Prom Dresses From One Of The Best Prom Dresses Online Shops, LunaDress Prom Shop 2Health News:NES Health Launches Stipend Program for Emergency Physicians in Training to Financially Assist Emergency Department Doctors While They Learn 2
... A new multicenter study involving UCLA and the RAND ... is not an uncommon experience among fifth-grade students and ... mental health. , Study results show ... they perceived as discrimination and that the vast majority ...
... a Working Lunch into a Walking Lunch April 29 PITTSBURGH, ... 100 calories; and, to burn the calories in an average ... of a football field 33 times. Experts agree on the ... walking being one of the easiest and most inexpensive ways ...
... "Live Your Life Well(SM)" Offers 10 Proven Tools to ... From financial worries to family responsibilities, Americans are dealing ... these challenges, Mental Health America today launched an innovative ... deal with stressful times. Called Live Your Life ...
... worrisome rise in childhood obesity, Florida school districts have ... there is little research available to determine if the ... $2.2 million grant from the National Institutes of Health ... Florida State University College of Medicine researcher will explore ...
... April 27 The grassroots forum AmericaSpeakOn.org ... emerges as a pandemic level event," said former Health and Human ... a safe vaccine is ready." He goes on to say ... world to react aggressively." The full statement ...
... PRINCETON, N.J., April 27 NJHA,s Valerie Sellers was ... workshop on emergency preparedness in New York. The regional ... are part of an Institute of Medicine initiative to ... a public health emergency. The lessons are applicable to ...
Cached Medicine News:Health News:Mental health problems more common in kids who feel racial discrimination 2Health News:Highmark Puts Employee Health First on National Walk@Lunch Day 2Health News:Highmark Puts Employee Health First on National Walk@Lunch Day 3Health News:New Campaign Helps Americans Deal With Stressful Times 2Health News:New Campaign Helps Americans Deal With Stressful Times 3Health News:FSU researcher wins $2.2 million grant to study childhood obesity 2Health News:FSU researcher wins $2.2 million grant to study childhood obesity 3Health News:AmericaSpeakOn.org Exclusive: Leavitt Asks 'How Prepared Is the US for the Swine Flu Pandemic?' 2Health News:NJHA's Sellers Serves on Institute of Medicine Preparedness Panel 2
(Date:12/19/2014)... DIEGO and CARDIFF-BY-THE-SEA, Calif. ... Inc. (NASDAQ: SRNE ;  Sorrento), an ... associated pain, and Conkwest, Inc., a privately-held immuno-oncology ... Natural Killer (NK) cell-line based therapy, announced today ... agreement to jointly develop next generation CAR-TNK™ (pronounced ...
(Date:12/19/2014)... Dec. 18, 2014 Somewhere between dropping five ... was forgotten. But Audicus , a next-generation hearing ... this new year. Hearing loss is the ... population, though it is often unaddressed. Forty-eight million Americans ... a hearing aid, mainly due to price. Hearing aids ...
(Date:12/19/2014)... , Dec. 18, 2014  Sage Analytics ( ... of equipment for the testing of marijuana potency ... the new Luminary™ Profiler, the industry,s first product ... in a cost-effective, portable unit. Designed ... needs of the cannabis industry, the Luminary™ Profiler ...
Breaking Medicine Technology:Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5Audicus Will Help People Resolve to Hear Better in 2015 2Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2
... NEC Corporation (NEC) and privately held SomaLogic, Inc. announced ... aptamer (*1) related businesses in the life sciences and ... made an equity investment in SomaLogic in support of ... The agreement establishes a framework for the two ...
... Hologic, Inc. (Nasdaq: HOLX ) today announced ... present at the 2010 Morgan Stanley Global Healthcare Conference ... Interested parties are invited to listen to ... the investor section of the company,s website at ...
Cached Medicine Technology:NEC and SomaLogic Enter Agreement to Prepare for Delivery of Novel Forms of Health Information via Cloud Services 2NEC and SomaLogic Enter Agreement to Prepare for Delivery of Novel Forms of Health Information via Cloud Services 3
Blunt tipped forceps with tungsten carbide treated jaws for enhanced gripping and removal of large sized foreign bodies....
Blunt tipped forceps with a thin tip angled at approximately 135 and hollowed out "notch" on the interior of the distal end. Tip is shaped like a pic when in the closed position. For membrane peeling...
Blunt tlpped forceps wlth smooth jaws that have been diamond dusted for enhanced grasping. Excellent for grasping of immature membranes....
Microforceps : Asymmetrical Endgripping Forceps...
Medicine Products: