Navigation Links
Biodegradable tooth-binding micelles inhibit Streptococcus mutans biofilm growth
Date:3/19/2011

San Diego, Calif., USA Today, during the 89th General Session & Exhibition of the International Association for Dental Research, held in conjunction with the 40th Annual Meeting of the American Association for Dental Research and the 35th Annual Meeting of the Canadian Association for Dental Research, lead researcher F. Cheni will hold an oral presentation on a research study titled "Biodegradable Tooth-binding Micelles Inhibit Streptococcus mutans (S. mutans) Biofilm Growth."

This research was performed under the objective to develop tooth-binding micelles(TBM) using peptide based biodegradable tooth-binding moieties that can effectively bind to the tooth surface to provide prolonged drug retention in the oral cavity, but can also safely detach from the tooth by gradual degradation of the peptide. Di-phosphoserine, tetra-phosphoserine and hexa-phosphoserine peptides were synthesized using a standard solid phase peptide synthesis method. These oligopeptides were conjugated to Pluronic P123 copolymer using a click reaction.

The tooth-binding micelle was prepared by self-assembly of the modified Pluronics with the antimicrobial agent triclosan. The binding kinetics of TBMs on hydroxyapatite (HA) particles was evaluated using a UV spectrophotometer. For in vitro biofilm prevention studies, HA discs were pretreated with different TBM formulations prior to inoculation with S. mutans UA159, and subsequent biofilm formation was assessed. Biofilm growth was measured by calculating the colony forming units (CFU) recovered per disc. Specific differences between the log-CFU/biofilm of each experimental group were analyzed using the Student t-test. A p-value of < 0.05 was considered as statistically significant.

The binding kinetics of TBMs on HA particles were found to be fast (< 1 min). Higher binding capacity was achieved using tetra- and hexa-phosphoserine as binding moieties. In biofilm prevention study, the TBM treated groups all showed significantly lower CFU (2 to 4-log reduction, p<0.05) per HA disc compared to the control groups.


'/>"/>

Contact: Ingrid L. Thomas
ithomas@iadr.org
703-299-8084
International & American Association for Dental Research
Source:Eurekalert

Related medicine news :

1. Green Genius Biodegradable Plastic Trash Bags Become First And Only Trash Bag Validated As Biodegradable By UL Environment
2. H1N1, Biodegradable Plastics and Nuclear Physics Highlight Research Areas Undertaken During Houghton College's Summer Research Institute
3. University of Michigan scientists identify chemical in bananas as potent inhibitor of HIV infection
4. Patients Who Take a Proton-Pump Inhibitor With Medicine to Prevent Blood Clots Are Less Likely to Be Hospitalized for Bleeding Ulcers
5. BRAF inhibitor shows promising preclinical activity against melanoma
6. Inhibiting fatty acids in immune cells decreases atherosclerosis risk
7. Inhibiting prostate cancer without disturbing regular body processes
8. Double-therapy approach effectively inhibited brain cancer recurrence
9. Selective inhibition of BMK1 suppresses tumor growth
10. JAK inhibitor provides rapid, durable relief for myelofibrosis patients
11. Novel biomarker may predict response to new VEGF receptor inhibitor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... Cambridge, MA (PRWEB) , ... February 09, 2016 ... ... Institute (WCRI) compares the workers’ compensation fee schedule rates and Medicare rates for ... medical services covered in the report, Evaluation of the 2015 Fee Schedule ...
(Date:2/9/2016)... Fairfax, VA (PRWEB) , ... February 09, 2016 , ... ... Maryland. The family scheduled an appointment after they noticed their furnace not producing any ... a cracked heat exchanger. The cracked heat exchanger was leaking dangerous levels of carbon ...
(Date:2/9/2016)... ... February 09, 2016 , ... METTLER TOLEDO has published ... have a basic understanding of the techniques they use so they can more ... them reduce waste and rework to create a leaner overall lab experience. ...
(Date:2/9/2016)... Rosa, California (PRWEB) , ... February 09, 2016 , ... ... rated one of the highest preliminary data vendors in the latest KLAS report, Population ... years, i2i has led the developing market for population health management (PHM). The ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... Human Nutrition into the Food & Beverage and Dietary Supplement ... channel partner throughout Canada and USA geographies east of the Rocky Mountains since ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... Alzheimer Diagnostic Tests - Medical Devices ... Devices sector report , "Alzheimer Diagnostic Tests - ... of Alzheimer Diagnostic Tests currently in pipeline stage. ... pipeline products with comparative analysis of the products ... major players involved in the pipeline product development. ...
(Date:2/8/2016)... , Feb. 8, 2016 CBG Technologies, ... PW Series Solvent Recycling Systems, specifically designed for ... integration with new and existing vapor degreasers, parts ... consistently-fresh solvent through continuous recycling and recovers 100% ... --> --> Precision parts manufacturers ...
(Date:2/8/2016)... India , February 8, 2016 ... a new market research report "Ablation Technologies Market by ... (Csardiovascular, Cancer, Pain Management, Cosmetic Surgery, Ophthalmology, Gynecology) - ... studies the global market over the forecast period of ... $4.44 Billion by 2020, at CAGR of 10.5% from ...
Breaking Medicine Technology: