Navigation Links
Biodegradable tooth-binding micelles inhibit Streptococcus mutans biofilm growth
Date:3/19/2011

San Diego, Calif., USA Today, during the 89th General Session & Exhibition of the International Association for Dental Research, held in conjunction with the 40th Annual Meeting of the American Association for Dental Research and the 35th Annual Meeting of the Canadian Association for Dental Research, lead researcher F. Cheni will hold an oral presentation on a research study titled "Biodegradable Tooth-binding Micelles Inhibit Streptococcus mutans (S. mutans) Biofilm Growth."

This research was performed under the objective to develop tooth-binding micelles(TBM) using peptide based biodegradable tooth-binding moieties that can effectively bind to the tooth surface to provide prolonged drug retention in the oral cavity, but can also safely detach from the tooth by gradual degradation of the peptide. Di-phosphoserine, tetra-phosphoserine and hexa-phosphoserine peptides were synthesized using a standard solid phase peptide synthesis method. These oligopeptides were conjugated to Pluronic P123 copolymer using a click reaction.

The tooth-binding micelle was prepared by self-assembly of the modified Pluronics with the antimicrobial agent triclosan. The binding kinetics of TBMs on hydroxyapatite (HA) particles was evaluated using a UV spectrophotometer. For in vitro biofilm prevention studies, HA discs were pretreated with different TBM formulations prior to inoculation with S. mutans UA159, and subsequent biofilm formation was assessed. Biofilm growth was measured by calculating the colony forming units (CFU) recovered per disc. Specific differences between the log-CFU/biofilm of each experimental group were analyzed using the Student t-test. A p-value of < 0.05 was considered as statistically significant.

The binding kinetics of TBMs on HA particles were found to be fast (< 1 min). Higher binding capacity was achieved using tetra- and hexa-phosphoserine as binding moieties. In biofilm prevention study, the TBM treated groups all showed significantly lower CFU (2 to 4-log reduction, p<0.05) per HA disc compared to the control groups.


'/>"/>

Contact: Ingrid L. Thomas
ithomas@iadr.org
703-299-8084
International & American Association for Dental Research
Source:Eurekalert

Related medicine news :

1. Green Genius Biodegradable Plastic Trash Bags Become First And Only Trash Bag Validated As Biodegradable By UL Environment
2. H1N1, Biodegradable Plastics and Nuclear Physics Highlight Research Areas Undertaken During Houghton College's Summer Research Institute
3. University of Michigan scientists identify chemical in bananas as potent inhibitor of HIV infection
4. Patients Who Take a Proton-Pump Inhibitor With Medicine to Prevent Blood Clots Are Less Likely to Be Hospitalized for Bleeding Ulcers
5. BRAF inhibitor shows promising preclinical activity against melanoma
6. Inhibiting fatty acids in immune cells decreases atherosclerosis risk
7. Inhibiting prostate cancer without disturbing regular body processes
8. Double-therapy approach effectively inhibited brain cancer recurrence
9. Selective inhibition of BMK1 suppresses tumor growth
10. JAK inhibitor provides rapid, durable relief for myelofibrosis patients
11. Novel biomarker may predict response to new VEGF receptor inhibitor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... Kansas (PRWEB) , ... May 05, 2016 , ... ... that some macroalgae can use ultraviolet light A (UV-A) for photosynthesis, researchers Juntian ... of red, green, and brown seaweeds. The pair observed that when photosynthetically active ...
(Date:5/5/2016)... MS (PRWEB) , ... May 05, 2016 , ... ... medical conditions and Make-A-Wish grants the most heartfelt wishes of these children. ... rounds of medical treatment. President and CEO of Make-A-Wish Mississippi, Brent Wilson ...
(Date:5/5/2016)... ... 2016 , ... Long Island’s fastest growing comprehensive eye care provider, North ... Kathleen Van Valkenburg, MD as part of their ongoing effort to increase ophthalmic coverage ... managing partner of North Shore Eye Care. , “We are extremely proud to ...
(Date:5/5/2016)... ... May 05, 2016 , ... TIME for Kids and The ZAC Foundation ... new partnership to reach nearly 1 million children with important water safety messages before ... the leading cause of accidental death in children one to 6 years of age. ...
(Date:5/5/2016)... ... May 05, 2016 , ... In honor of National Nurses Week 2016, ... the United States to thank a nurse who's made a difference in their life. ... the American Red Cross of San Diego/Imperial Counties (up to $10,000) every time someone ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... , May 5, 2016 Progra m ... trial of Oxitec , s mosquito in ... aegypti by 96 %   ... new plan to fight wild Aedes aegypti, the dangerous mosquito that ... the island of Grand Cayman .  MRCU, a global leader ...
(Date:5/5/2016)... , May 5, 2016 Research ... PET Imaging in Top 5 EU Markets"  report to their ... This report provides information on the current Positron Emission Tomography ... European Markets (T5 EU), which includes France ... , Spain and the ...
(Date:5/5/2016)... DUBLIN , May 5, 2016 /PRNewswire/ ... the addition of the  "Europe Thalassaemia Market ... to their offering.       (Logo: ... research Europe Thalassaemia Market and Competitive Landscape ... Thalassaemia pipeline products, Thalassaemia epidemiology, Thalassaemia market ...
Breaking Medicine Technology: