Navigation Links
Biochemist studies DNA repair with $787,000 in grants
Date:9/20/2010

CLEMSON, S.C. A Clemson biochemist has received grants totaling $787,000 to study how cells repair damaged DNA, which can cause cancer and genetic illnesses. The U.S. Department of Defense (DoD) and the National Institutes of Health (NIH) awarded Weiguo Cao three-year funding to investigate two DNA repair pathways.

"We hope these studies will not only help us understand the basic mechanisms of DNA repair but also help us understand how DNA repair contributes to cancer prevention," said Cao, associate professor in the genetics and biochemistry department.

The integrity of the DNA sequence is important for proper cell function. Mutations to its chemical structure are most commonly corrected by DNA repair, a biochemical tool kit that fixes breaks and mistakes in the genetic code. DNA-repair proteins can search through pieces of DNA to find subtle mistakes in the code and repair them. It is necessary because genes are continually assaulted by "troublemakers" inside cells and from the environment.

Unrepaired DNA can lead to mutations, which may accumulate and lead to cancer and other illnesses. Some of the drugs used in cancer treatments work by intentionally damaging DNA. Their success can be influenced by DNA repair activities. A clearer understanding of DNA repair may offer to improve cancer therapy.

"The link between DNA repair and cancer is well known in some instances," Cao said. "For example, some people are susceptible to skin cancer due to defect in DNA repair.

"My lab studies a repair process for another cause of DNA mistakes: deamination. Deamination damages DNA, causing part of the genetic code to be copied wrong that results in mismatched pairings of biochemicals that contain the instructions for proper cell function," he said. "We want to know how DNA repair enzymes find the damage and remove it. The research can help understand how defects in repair of deaminated DNA cause cancer."

Military personnel and civilians alike are exposed to various cellular stresses: inflammation, infection, genetic code duplication errors, ultraviolet light, air pollution and cancer-causing substances. DNA in a cell may be damaged more than 10,000 times a day. DNA repair functions so well that there is less than a one-in-a-billion chance for a mutation to take hold.

Cao is grateful for funding. "I appreciate the support of the DoD and NIH provided to my lab in this challenging time for research grants," he said.

Papers by Cao's and his collaborators' laboratories that describe the DNA repair research have been published in such international journals as the Journal of Molecular Biology, Nature Structural and Molecular Biology, and the Journal of Biological Chemistry.


'/>"/>

Contact: Weiguo Cao
wgc@clemson.edu
864-656-4176
Clemson University
Source:Eurekalert

Related medicine news :

1. UC studies show marijuana has therapeutic value, reports to legislature
2. Second Dose of Gene Therapy for Inherited Blindness Proves Safe in Animal Studies
3. Studies Detail Possible Benefits of omega-3 Fatty Acids for Dogs With Arthritis
4. COPPERTONE(R) Solar Research Center Unveils Studies on Efficacy of Topical Antioxidants in Sunscreens at 2010 Annual Meeting of The American Academy of Dermatology
5. Promega - TOP srl Agreement Enables Live Animal Imaging for Cancer Studies
6. Most Drug Studies Dont Help Docs Pick Best Treatment
7. Gays, Lesbians Excluded From Some Medical Studies
8. Studies Show Significant Increases of C. Difficile Infections (CDI)
9. Studies examine Third Eye Retroscope during colonoscopy
10. Statement of Ralph B. Everett, President and CEO, Joint Center for Political and Economic Studies, on House Passage of Health Reform Legislation
11. New studies on surgical options in inherited breast cancer show drastic treatment is not always best
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her son ... lash out at his family verbally and physically. , “When something upset him, he couldn’t ... would use it. He would throw rocks at my other children and say he was ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CHAPEL HILL, N.C. , June 24, 2016 ... in healthcare decisions and regulators/payers have placed more ... this new environment, patient support programs in the ... support for patients, medications. Consequently, pharmaceutical companies are ... to ensure they are providing products and services ...
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... 2016 The Academy of Managed Care Pharmacy ... that would allow biopharmaceutical companies to more easily share ... formulary and coverage decisions, a move that addresses the ... The recommendations address restrictions in the sharing ... drug label, a prohibition that hinders decision makers from ...
Breaking Medicine Technology: