Navigation Links
Biochemical signature predicts progression to Alzheimer's disease
Date:12/14/2011

were diagnosed with AD, MCI, or identified as healthy controls. 52 out of 143 MCI patients progressed to AD during the follow-up period of 27 months on average. A molecular signature comprising three metabolites measured at baseline was derived which was predictive of progression to AD. Furthermore, analysis of data in the context of metabolic pathways revealed that pentose phosphate pathway was associated with progression to AD, also implicating the role of hypoxia and oxidative stress as early disease processes.

The unique study setting allowed the researchers to identify the patients diagnosed with MCI at baseline who later progressed to AD and to derive the molecular signature which can identify such patients at baseline.

Though there is no current therapy to prevent AD, early disease detection is vital both for delaying the onset of the disease through pharmacological treatment and/or lifestyle changes and for assessing the efficacy of potential AD therapeutic agents. The elucidation of early metabolic pathways associated with progression to Alzheimer's disease may also help in identifying new therapeutic avenues.


'/>"/>

Contact: Matej Oresic
matej.oresic@vtt.fi
358-207-224-491
VTT Technical Research Centre of Finland
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Moffitt Cancer Center researchers unravel biochemical factor important in tumor metastasis
2. Researchers discover biochemical weakness of malaria parasite -- vaccine to be developed
3. News tips from the May/June issue of Physiological and Biochemical Zoology
4. Biochemical and Molecular Engineering XVII Conference
5. NutriLuxe Offers Personal, At-Home Body Biochemical Balance Test
6. Toronto researchers obtain detailed molecular signature for Tankyrase
7. Lung cancer signatures in blood samples may aid in early detection
8. Penn researchers find neural signature of mental time travel
9. Researchers home in on genetic signature of esophageal cancer
10. Genomic signature in post-menopausal women may explain why pregnancy reduces breast cancer risk
11. Molecular signatures may aid fight against pediatric liver disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... This week marks a significant milestone ... week of paying commissions to its independent distributor sales ... January 2005 total $1,405,954,677.06. , MonaVie distributors can be ... pays commissions in 18 different currencies, including: AUD, EUR, ... PLN, USD, SGD, KRW, TWD, THB and GBP. ...
(Date:8/1/2014)... A leading dress supplier, Discount-Dress.com, explores a variety of ... any lady’s wardrobe fashionable and exciting. Recently, the company has ... To attract more people, it is now launching a special ... to 65% off. , “Summer is the season of short ... to our collection of ‘ 2014 summer short styles .’ ...
(Date:8/1/2014)... August 01, 2014 Transparency Market ... the addition of a comprehensive report on the ... System Market (Large Volume, Disposable, Syringe, Ambulatory and ... Trends And Forecast, 2013 – 2019’ is now ... http://www.transparencymarketresearch.com . , To begin with, the report ...
(Date:8/1/2014)... CentraComm, a leading managed IT security ... the Pure Storage® Authorized Reseller program. , ... experience designed to meet the rigorous resiliency, scalability, ... diverse markets, and for a variety of high ... years. , The Pure Storage FlashArray was ...
(Date:8/1/2014)... HealthDay Reporter THURSDAY, July 31, 2014 ... Africa has a well-earned reputation as one of the world,s ... intense medical care can greatly improve a person,s chances of ... wreaks life-threatening havoc within the body by attacking multiple organ ... back on the basics of "good meticulous intensive care," supporting ...
Breaking Medicine News(10 mins):Health News:MonaVie Records 500th Commission Week, Having Paid Out More Than $1.4B in Distributor Commissions 2Health News:Discount-Dress.com’s Top Trend Report: 2014 Summer Short Bridesmaid Dresses Now for Sale 2Health News:Transparency Market Research Adds Report on Global Infusion System Market to its Repository 2Health News:Transparency Market Research Adds Report on Global Infusion System Market to its Repository 3Health News:CentraComm Accepts Pure Storage Authorized Reseller Partner Invitation 2Health News:CentraComm Accepts Pure Storage Authorized Reseller Partner Invitation 3Health News:There's No Ebola Cure, But Early Intensive Treatment Boosts Survival 2Health News:There's No Ebola Cure, But Early Intensive Treatment Boosts Survival 3
... Lifeclinic International is this year,s Gold Sponsor of the Harvard Business ... Joseph B. Martin Conference Center, Harvard Medical School, November 6 - ... ... 2008 -- Lifeclinic International, Inc. , the world,s leading manufacturer ...
... Jazz,Pharmaceuticals, Inc. (Nasdaq: JAZZ ) announced today ... On Tuesday, November 11, 2008 at 2:50 p.m. ... a corporate presentation at the,Rodman & Renshaw 10th Annual ... November 12, 2008 at 3:30 p.m. MST (5:30 p.m. ...
... Product Will Be Sold by A Uniquely-Trained Sales ... ... Group plc,(LSE: PSK) today announced that SANCUSO(R) (Granisetron Transdermal System),is now available ... States. Sancuso was approved by,the U.S. Food and Drug Administration (F.D.A.) in ...
... have vaccination rates far below goals, study finds , , ... adolescents with asthma and other high-risk illnesses are getting ... vaccination rates from 1992 to 2002 for 18,703 adolescents ... conditions. , During the study period, vaccination rates improved, ...
... Fifteen Abstracts Will Be Featured at ASN, ... a leading,provider of kidney care services for those ... DaVita Clinical Research(R) (DCR),recently contributed fifteen abstracts to ... American Society of Nephrology. These,abstracts were developed both ...
... Nov. 4 The Quantum Group,Inc. (Amex: ... today that Noel J. Guillama, President & Chief ... Annual Westergaard,Conference on November 12, 2008. Mr. Guillama ... and Chief Technology & Innovations Officer,and Ron Smith, ...
Cached Medicine News:Health News:Lifeclinic International Lead Sponsor at Harvard Business School Health Conference 2Health News:SANCUSO(R), the First and Only Patch for Preventing Nausea and Vomiting in Chemotherapy Patients, Now Available 2Health News:SANCUSO(R), the First and Only Patch for Preventing Nausea and Vomiting in Chemotherapy Patients, Now Available 3Health News:Too Many High-Risk Teens Not Getting Flu Shots 2Health News:DaVita Abstracts Accepted into American Society of Nephrology Meeting 2Health News:DaVita Abstracts Accepted into American Society of Nephrology Meeting 3Health News:DaVita Abstracts Accepted into American Society of Nephrology Meeting 4Health News:The Quantum Group Inc. To Present at Paulson Investment's 31st Annual Westergaard Conference 2Health News:The Quantum Group Inc. To Present at Paulson Investment's 31st Annual Westergaard Conference 3
(Date:8/1/2014)... 1, 2014 Research and Markets ... "Global Medical Biosensors Market 2014-2018" report to ... Medical biosensors are used to ... detectors. These biosensors monitor health status, disease betterment, ... methods. They are cost-effective and user-friendly devices. Also, ...
(Date:8/1/2014)... PALO ALTO, Calif. , Aug. 1, ... (CFRI) today announced a partnership to expand awareness of ... through the CFChef Shares program. CFChef Shares will run ... of AbbVie,s CFChef program – an online resource for ... maintain a healthy diet by submitting recipes to the ...
(Date:8/1/2014)... DALLAS , August 1, 2014 ... Care Market by Type (Traditional Wound Closure, Anti infective), ... Active (Artificial Skin & Skin Substitutes), Pressure Relief ... by MarketsandMarkets, the global Wound Care Market is expected ... Billion in 2014, growing at a CAGR of ...
Breaking Medicine Technology:Global Medical Biosensors Market 2014-2018: Key Vendors are Abbott, Bayer, LifeScan and F. Hoffmann-La Roche 2AbbVie and Cystic Fibrosis Research, Inc. (CFRI) Team Up to Raise Awareness of the Nutritional Needs of CF Patients through the CFChef Shares Program 2AbbVie and Cystic Fibrosis Research, Inc. (CFRI) Team Up to Raise Awareness of the Nutritional Needs of CF Patients through the CFChef Shares Program 3Wound Care Market Worth $18.3 Billion by 2019 2Wound Care Market Worth $18.3 Billion by 2019 3
Ballard trach care HMES and filters, tv 1500, HME with built-in flex tube...
Indications For Usage: ,Single patient use on anesthetized patients and respiratory care patients who require a breathing circuit. The product is intended to be replaced at least once every 24 hours...
... The Portex® Thermovent® T helps provide protection to ... is small and extremely lightweight making it ideal ... With a high rate of heat and moisture ... retention., ,All HMEs and filters have ISO ...
... helps provide protection to the exposed airway of ... lightweight making it ideal for active young children ... of heat and moisture recovery, it ensures patient ... and filters have ISO standard tapered ends to ...
Medicine Products: