Navigation Links
Biochemical markers for non-invasive assessment of primary biliary cirrhosis

Needle liver biopsy has been used as the "gold standard" for the assessment of liver fibrosis and disease stage of PBC . Due to possible complications of this procedure, for both, the physician and the patient, the decision to proceed with liver biopsy is not trivial one. So, scientists tend to introduce non-invasive methods for assessment of liver diseases stages.

A research article to be published on February 7, 2009 in the World Journal of Gastroenterology addresses this question. In the literature, The research team was led by Tamara Alempijevic found a statistical significant correlation between PBC stage and AST, APRI, ALT/platelet, AST/ALT, ALT/AST and ALT/Chol ratio. The best sensitivity and specificity was shown for AST/ALT, with the area under ROC of 0.660.

Based on these results, they concluded that use of biochemical markers and their ratios in clinical evaluation of PBC patients may reduce, but not eliminate the need for liver biopsy.


Contact: Lin Tian
World Journal of Gastroenterology

Page: 1

Related medicine news :

1. Scientists Spot Biochemical Sign of Depression
2. Major missed biochemical pathway emerges as important in virtually all cells
3. Prenatal biochemical screening only detects half of chromosomal abnormalities
4. UCLA researchers identify markers that may predict diabetes in still-healthy people
5. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
6. Study makes progress in zoning in on biomarkers for better colon cancer treatment
7. Study shows blood markers can help choose best dose for antiangiogenic drugs
8. Biomarkers predict risk for invasive breast cancer years before the tumor develops
9. 2 proteins may be survival markers in some breast cancers
10. JDRF and Lilly partner to fund research to identify beta cell biomarkers
11. Biomarkers for Alzheimers disease can be trusted in clinical trials
Post Your Comments:
(Date:11/25/2015)... ... , ... Smiles by Stevens is pleased to announce the addition ... many patients are aware of the benefits of Botox® in the treatment of moderate ... with discomfort, soreness, and pain as a result of Jaw Tension, TMJ (temporo-mandibular joint) ...
(Date:11/25/2015)... ... 2015 , ... Brillianteen, McGaw YMCA’s student-produced musical show, will ... Anniversary Brillianteen Revue, scheduled for March 4-6, 2016. Auditions for this final production ... been a treasured tradition for numerous families in the Evanston community. Over the ...
(Date:11/25/2015)... ... 25, 2015 , ... Today, Mothers Against Drunk Driving (MADD) learned ... 10,000 for the first time since 2011. In 2014, there were 9,967 fatalities involving ... by the National Highway Traffic Safety Administration (NHTSA), 32,675 people were killed in traffic ...
(Date:11/25/2015)... ... November 25, 2015 , ... "When ... that regular bras were incredibly uncomfortable," said an inventor from Bronx, N.Y. "In ... She developed the patent-pending RECOVERY BRA for added comfort and support. The bra ...
(Date:11/25/2015)... ... November 25, 2015 , ... Many people know of the ... gain, cold hands, and dry skin. But many people who find their cholesterol levels ... regimen instead of their thyroid, especially if they don’t have any of the other ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , November 25, 2015 ... the addition of the  "Global Drug ...  report to their offering.  --> ... addition of the  "Global Drug Device ... to their offering.  --> ...
(Date:11/24/2015)...  Array BioPharma Inc. (Nasdaq: ARRY ) ... Ron Squarer , will present at the Piper ... public is welcome to participate in the conference ... Jaffray Annual Healthcare ConferencePresenter:  , Ron Squarer, Chief ... Eastern Time Webcast: , ...
(Date:11/24/2015)... NEWPORT NEWS, Va. , Nov. 24, 2015 /PRNewswire/ ... that they have signed an agreement for DILON to ... select geographies across the globe. The signing of this distribution ... GE,s Discovery NM750b Molecular Breast Imaging system and is ... ways to provide better healthcare solutions for clinicians and ...
Breaking Medicine Technology: