Navigation Links
Bioartificial Kidney Cuts Death Risk, Improves Outcomes
Date:4/30/2008

In small study, device helped a little more than half of patients recover renal function

WEDNESDAY, April 30 (HealthDay News) -- Another successful clinical trial suggests that a bioartificial kidney to save the lives of people with acute renal failure will be available within a few years.

This latest study found that short-term replacement of renal cell function using the renal tubule assist device (RAD) -- the living cartridge that's critical to the function of the bioartificial kidney -- significantly reduced death risk and sped recovery of kidney function in patients with acute renal failure resulting from acute kidney injury.

The study of 58 critically ill patients, aged 18 to 80, found that the death rate after 28 days was 33 percent for patients who received continuous venovenous hemofiltration combined with RAD, compared to 66 percent for patients who received the more traditional continuous renal replacement therapy. At day 28, 53 percent of the patients in the RAD group had recovered renal function.

In the 180 days following treatment, patients in the RAD group had a 50 percent reduction in death risk. The study was published online in the Journal of the American Society of Nephrology.

"Our study results are encouraging, and they raise expectations that our new approach may yield a better treatment for life-threatening acute renal failure, for which a high mortality rate has remained unchanged [50 percent to 70 percent] despite years of advances in conventional therapies," study author Dr. H. David Humes, a professor of internal medicine at the University of Michigan School of Medicine, said in a prepared statement.

"Even more promising, the nature of our new approach -- using living cells as therapeutic agents -- argues for the feasibility of developing whole classes of new cell-based and tissue-engineered therapies," Humes said.

While this was a small study, he said it offers encouragement that a related device -- a wearable kidney that performs natural functions -- can be developed in the near future to treat people with chronic renal failure.

"The ability to harness vital processes of cells, to target their living molecular machinery on restoring critical substances which have become disordered by disease, has vast implications for the future of medicine," Humes said. "The apparently successful use of living cells in this way validates our approach and should encourage others to investigate cell therapies for a range of disorders."

He and his colleagues started developing the bioartificial kidney more than a decade ago. The device includes a cartridge that filters the blood as in traditional kidney dialysis. The cartridge is connected to the RAD, which is made of hollow fibers lined with a type of kidney cell called renal proximal tubule cells, which reclaim vital electrolytes, salt, glucose and water, and control production of immune system molecules called cytokines, which fight infection.

More information

The American Academy of Family Physicians has more about kidney failure.



-- Robert Preidt



SOURCE: University of Michigan Health System, news release, April 24, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Kidney Care Community Applauds National Taxpayers Unions Endorsement of Medicare Reforms to Extend Patient Private Health Insurance Coverage; Calls Proposal Common Sense Coverage Reform
2. Cutting Phosphate May Protect Kidney Patients From Heart Trouble
3. Muscle Mass May Not Explain High Creatinine in Black Kidney Patients
4. Readily available treatment could help prevent heart disease in kidney patients
5. Study Points to New Treatments for Polycystic Kidney Disease
6. Raloxifene Safe for Women With Decreased Kidney Function
7. Kidney cancer deaths show overall decrease in Europe
8. Diplomat Specialty Pharmacy Hires National Accounts Director To Expand Kidney Disease Services
9. Northwestern Memorial Successfully Completes Rare Four-Way Domino Paired Kidney Exchange Transplant Surgery
10. Kidney Community Gathers on Capitol Hill to Ask Congress to Support Legislation for Increased Kidney Care Education, Updates for Kidney Dialysis Benefit
11. Hospital Clínic conducts the first kidney extraction through the vagina in Europe
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & ... and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to ... with elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... 13, 2017 , ... “America On The Brink”: the Christian history of the ... is the creation of published author, William Nowers. Captain Nowers and his wife, ... he spent thirty years in the Navy. Following his career as a naval ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one ... an innovative new design of the shoulder pad. The shoulder pad provides optimal ... controlling your pain while using cold therapy. By utilizing ice and water that is ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader ... a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were ... 11, 2017. , The annual award competition recognizes editorial and design excellence across a ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... 4, 2017  According to the Centers for Disease Control and Prevention ... . PhysicianOne Urgent Care is helping communities across Massachusetts ... , by offering no-cost* flu shots through the end of the month. ... health insurance regulations. ... to get a flu shot is by the end of October, according ...
(Date:10/2/2017)... -- Eli Lilly and Company (NYSE: LLY ) ... of 2017 on Tuesday, October 24, 2017. Lilly will ... the investment community and media to further detail the ... begin at 9 a.m. Eastern time. Investors, media and ... the conference call through a link that will be ...
(Date:10/2/2017)... Oct. 2, 2017 The Rebound mobile app is ... to reverse the tide of prescription drug addiction. The app ... medicine intake and stepping down their dosage in a safe, ... in December 2017; the first 100,000 people to sign up ... http://www.rebound-solution.com/ ...
Breaking Medicine Technology: