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BioSphere Medical's HepaSphere Microspheres Safely Deliver Doxorubicin in Liver Cancer Chemoembolization Therapy -- Study Presented at SIR
Date:3/16/2010

cancer in the United States.    

HepaSphere™ Microspheres, however, have been CE marked in the European Union since 2007 for embolization of liver cancer and hepatic metastases, with or without delivery of doxorubicin. In the United States, QuadraSphere® is cleared by the FDA for embolization of hypervascularized tumors and peripheral arteriovenous malformations.

Surgical removal is not possible for more than two-thirds of primary liver cancer patients and 90 percent of patients with secondary liver cancer. According to the U.S. National Cancer Institute (NCI), no standard treatment currently exists for liver cancer when tumors cannot be surgically removed and liver transplantation is not a viable option.

In a related presentation, Diane K. Reyes, Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, presented results of a Phase II two-year, single-arm clinical study that treated patients with unresectable liver cancer with bevacizumab (Avastin®) and conventional TACE (cTACE) using Embosphere® Microspheres. This pilot study evaluated tumor response and safety of liver chemoembolization combined with an antiangiogenic drug that works by preventing new blood vessel growth. The data showed treatment was well tolerated, with progression-free survival of 16 months.

BioSphere Medical, Inc. (NASDAQ:BSMD) is a medical device company that develops and manufactures bioengineered microspheres for use in embolotherapy, which is the minimally invasive treatment of tumors and vascular malformations by inhibiting blood flow. The Company's core technologies, patented bioengineered polymers and manufacturing methods, are used to produce microscopic spherical materials with properties that may be beneficial in a variety of medical applications. Most notably, the company was a pioneer in uterine fibroid embolization (UFE) when it launched the first ap
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