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BioMarin and La Jolla Pharmaceutical Sign Worldwide (Excluding Asia Pacific) Development and Commercialization Agreement for Riquent
Date:1/6/2009

d uncertainties, and a number of factors, both foreseen and unforeseen, that could cause actual results to differ materially from BioMarin and La Jolla's current expectations. Forward-looking statements include those that express a plan, belief, expectation, estimation, anticipation, intent, contingency, future development or similar expression. There can be no assurance that actual results will be consistent the expectations reflected in BioMarin and La Jolla's forward looking statements. For example, there can be no assurance that: the ASPEN trial will be successful or that Riquent will be approved for marketing; the ASPEN trial will proceed on schedule as currently planned; La Jolla will receive any contingent payments under the license agreement with BioMarin or even if Riquent is approved, that it will be successfully marketed. These or other risks are discussed under the caption "Risk Factors" in BioMarin and La Jolla's most recent Annual Reports on Form 10-K and subsequent Quarterly Reports on Form 10-Q, as filed with the SEC. Accordingly, you should not rely upon forward-looking statements as predictions of future events. We expressly disclaim any intent to update forward-looking statements.

    BioMarin Pharmaceutical Inc.             La Jolla Pharmaceutical Company

    Investors                                Investors
    Eugenia Shen                             Andrew Wiseman, Ph.D.
    (415) 506-6570                           (858) 646-6615
    eshen@bmrn.com                           andrew.wiseman@ljpc.com

    Media                                    Media
    Susan Berg                               Edward Agne
    (415) 506-6594                           The Communications Strategy Group
    sberg@bmrn.com                           (781) 631-3117
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SOURCE BioMarin Pharmaceutical Inc.; La Jolla Pharmaceutical Company
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