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BioCryst Pharmaceuticals Announces Presentation of Forodesine Data at the 45th Annual Meeting of the American Society of Clinical Oncology
Date:5/14/2009

ew consent and one discontinued due to an adverse event (diffuse large b-cell lymphoma). The median time on treatment for these six patients was 440 days. Through October 1, 2008, the other three patients remained on therapy for 416, 710 and 863 days, respectively.

"This Phase 2 trial further shows the safety and efficacy of an oral PNP inhibitor, forodesine, for CTCL patients of all stages who have failed standard therapies," said Madeleine Duvic, M.D., Professor of Medicine and Dermatology, Deputy Chairman, Department of Dermatology at the MD Anderson Cancer Center.

"We believe these data further support the clinical utility of forodesine as a treatment for CTCL and are encouraged by its safety and efficacy profile in this study," said Dr. William P. Sheridan, BioCryst's Chief Medical Officer. "We continue to actively enroll patients in our pivotal Phase 2 study of forodesine in patients with CTCL and look forward to results from this study in the first half of next year."

Of the nine patients that received forodesine treatment for 12 or more months, the most frequent adverse events were nausea (44 percent), fatigue (22 percent), peripheral edema (22 percent), dyspnea (22 percent) and urinary casts (22 percent). Grade 3 or higher adverse events were diffuse large B-cell lymphoma and peripheral edema. There were no hematologic or infection adverse events related to forodesine. Grade 3 lymphopenia and a CD4 count of less than 200 were noted in eight of the nine subjects and four of the nine subjects, respectively.

About BioCryst

BioCryst is a biopharmaceutical company that has developed a deep pipeline of novel therapeutics targeting major illnesses by employing crystallography and structure-based drug design. BioCryst is currently advancing investigational new drugs discovered in-house in late-stage clinical trials for influenza and lymphoma. In addition, the Com
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