Navigation Links
Binge eating curbed by deep brain stimulation in animal model, Penn study shows
Date:4/24/2013

PHILADELPHIA - Deep brain stimulation (DBS) in a precise region of the brain appears to reduce caloric intake and prompt weight loss in obese animal models, according to a new study led by researchers at the University of Pennsylvania. The study, reported in the Journal of Neuroscience, reinforces the involvement of dopamine deficits in increasing obesity-related behaviors such as binge eating, and demonstrates that DBS can reverse this response via activation of the dopamine type-2 receptor.

"Based on this research, DBS may provide therapeutic relief to binge eating, a behavior commonly seen in obese humans, and frequently unresponsive to other approaches," said senior author Tracy L. Bale, PhD, associate professor of neuroscience in Penn's School of Veterinary Medicine's Department of Animal Biology and in the Perelman School of Medicine's Department of Psychiatry. DBS is currently used to reduce tremors in Parkinson's disease and is under investigation as a therapy for major depression and obsessive-compulsive disorder.

Nearly 50 percent of obese people binge eat, uncontrollably consuming palatable highly calorie food within a short period of time. In this study, researchers targeted the nucleus accumbens, a small structure in the brain reward center known to be involved in addictive behaviors. Mice receiving the stimulation ate significantly less of the high fat food compared to mice not receiving DBS. Following stimulation, mice did not compensate for the loss of calories by eating more. However, on days when the device was turned off, binge eating resumed.

Researchers also tested the long-term effects of DBS on obese mice that had been given unlimited access to high-fat food. During four days of continuous stimulation, the obese mice consumed fewer calories and, importantly, their body weight dropped. These mice also showed improvement in their glucose sensitivity, suggestive of a reversal of type 2 diabetes.

'/>"/>
Contact: Kim Menard
kim.menard@uphs.upenn.edu
215-662-6183
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Even in Young Adults, Binge Drinking May Harm Circulation
2. Lack of Sleep May Lead to Junk-Food Bingeing
3. Lower Drinking Age May Raise Chances of Bingeing Later
4. Lower drinking ages lead to more binge drinking
5. Sovereign Health of California Is Concerned About Recent CDC Findings Highlighting The Health Risk of Alcohol Abuse And Binge Drinking Among Women
6. Binge drinking increases risk of Type 2 diabetes by causing insulin resistance
7. Binge Drinking Common Among U.S. Women, Girls: CDC
8. Strange Food Pairings May Signal Binge Eating: Study
9. Young Binge Eaters Prone to Illicit Drug Use: Study
10. College Students Who Binge Drink Say Theyre Happier
11. Binge drinking college students are happier than their non-binge drinking peers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... Global Partnership for TeleHealth ... platform to bring quality healthcare to populations in ... created Global Partnership for TeleHealth Missions (GPTM), a ... network. GPTM focuses specifically on medical missions ... relief organizations. , Michael D’Ambrosio, Director ...
(Date:11/18/2014)... Fe, NM (PRWEB) November 18, 2014 ... Elizabeth Showers , showcasing a special selection of her beautiful, ... is encouraged to stroll in to the gallery, Friday, December ... Art Walk in Santa Fe. , Showers artistic creations began ... and those memories continue to inspire her designs. She studied ...
(Date:11/18/2014)... HealthDay Reporter , MONDAY, ... therapy may not have significant heart-health benefits for older ... involved more than 14,000 Japanese people aged 60 to ... non-fatal heart attacks and strokes between people who took ... that primary prevention with daily low-dose aspirin does not ...
(Date:11/18/2014)... By Randy Dotinga ... -- Millions of Americans use smartphone apps that help them ... new study finds that people who used a popular one ... The study doesn,t conclusively debunk the idea of using ... in the first place, and their level of motivation varied, ...
(Date:11/17/2014)... November 17, 2014 QuickChek customers and ... September “Dog Tag” Promotion. In total, the ... For The Warriors® in support of military families both ... a national nonprofit dedicated to restoring a sense of ... our service members and our military families. , ...
Breaking Medicine News(10 mins):Health News:Global Partnership for TeleHealth (GPT) is Focused on Using the telehealth Platform to Bring Quality Healthcare to Populations in Need Worldwide 2Health News:Elizabeth Showers Trunk Show & Personal Appearance Hosted by Sorrel Sky Gallery 2Health News:Daily Aspirin Fails to Help Older Hearts in Japanese Study 2Health News:Daily Aspirin Fails to Help Older Hearts in Japanese Study 3Health News:Calorie-Tracking Apps May Not Help You Lose Weight 2Health News:Calorie-Tracking Apps May Not Help You Lose Weight 3Health News:QuickChek Gives Big Support to Hope For The Warriors One Dollar at a Time 2
... invaluable advice to women of childbearing age, who would indeed ... risks of delivering a child with birth defects. // , ... regular with intake of vitamins and minerals, the risk of ... can be offset include neural-tube defects such as spina bifida, ...
... zoomed in on a region in the brain, previously understood ... capacity.// The latest finding has revealed that this region is ... The neurons also double up their response to objects- automobiles, ... theories suggest neurons in a portion of the brain called ...
... Medical Center Dallas say that rather than immature tissue ... by cancer. The research was done on fruit files ... clues in search for other cancer genes.,"Never before has ... be generated from differentiated skeletal muscle," said Dr. Rene ...
... the possible link between these changes and the disease will ... School of Medicine// . ,Comparison of post-mortem brain ... the tissue from normal people will be done by the ... National Institute of Mental Health. ,The principal investigator, ...
... that the media is insensitive to the disease and hence ... ,"I have come across journalists refusing to shake hands, ... look at my eyes during interview sessions. I always thought ... president of the Positive Network of Mizoram (PNM). Vanlalmuana is ...
... each other and fight social stigma, HIV carriers in Jharkhand ... for People Living with HIV has 200 members. More are ... HIV carriers in a humane manner. It will also seek ... proper accommodation for the infected. ,'Driving out ...
Cached Medicine News:Health News:Region in the brain in-charge of face recognition includes object recognition as well. 2Health News:Cancer Affects Mature Muscle Fibers 2Health News:Brain changes in schizophrenia to be analyzed 2Health News:Brain changes in schizophrenia to be analyzed 3
(Date:11/18/2014)... , Nov. 18, 2014 BioLink ... International Technology Transfer Summit, co-organized by CCCMHPIE ( ... Export of Medicines & Health Products), UBM Live ... January 22nd and 23rd, 2015 at Beijing Yizhuang Biomedical ...   This event will gather ...
(Date:11/18/2014)... Nov. 18, 2014 Pressure BioSciences, Inc. ... the installation of its first two Barozyme HT-48 ... potential sale. One system was placed in the ... Georgetown University while the other was placed in ... both settings, the Company believes the new systems ...
(Date:11/18/2014)... 17, 2014  Concord Medical Services Holdings Limited ... CCM ), an operator of specialty cancer hospitals ... imaging centers in China, today announced its unaudited ... September 30, 2014 [1] . Third ... which consists of net revenues generated from the ...
Breaking Medicine Technology:BioLink 2015 Will be Held on Jan 22, 2015, with a Focus on Biopharma Industrial Innovation & International Technology Transfer 2BioLink 2015 Will be Held on Jan 22, 2015, with a Focus on Biopharma Industrial Innovation & International Technology Transfer 3Pressure BioSciences Ships First Two Barozyme HT48 Systems 2Pressure BioSciences Ships First Two Barozyme HT48 Systems 3Pressure BioSciences Ships First Two Barozyme HT48 Systems 4Pressure BioSciences Ships First Two Barozyme HT48 Systems 5Concord Medical Reports Third Quarter 2014 Financial Results 2Concord Medical Reports Third Quarter 2014 Financial Results 3Concord Medical Reports Third Quarter 2014 Financial Results 4Concord Medical Reports Third Quarter 2014 Financial Results 5Concord Medical Reports Third Quarter 2014 Financial Results 6Concord Medical Reports Third Quarter 2014 Financial Results 7Concord Medical Reports Third Quarter 2014 Financial Results 8Concord Medical Reports Third Quarter 2014 Financial Results 9Concord Medical Reports Third Quarter 2014 Financial Results 10Concord Medical Reports Third Quarter 2014 Financial Results 11Concord Medical Reports Third Quarter 2014 Financial Results 12Concord Medical Reports Third Quarter 2014 Financial Results 13Concord Medical Reports Third Quarter 2014 Financial Results 14Concord Medical Reports Third Quarter 2014 Financial Results 15Concord Medical Reports Third Quarter 2014 Financial Results 16Concord Medical Reports Third Quarter 2014 Financial Results 17Concord Medical Reports Third Quarter 2014 Financial Results 18
... 8, 2011 Reportlinker.com announces that a new ... South and Central America Drug ... http://www.reportlinker.com/p0548442/South-and-Central-America-Drug-Delivery-Devices-Market-Outlook-to-2017.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=NoCategory South and ... 2017 Summary ...
... announces that a new market research report is ... America Drug Delivery Devices Market Outlook to 2017 ... North America Drug Delivery Devices Market Outlook to ... GlobalData,s new report, "North America Drug Delivery Devices ...
Cached Medicine Technology:Reportlinker Adds South and Central America Drug Delivery Devices Market Outlook to 2017 2Reportlinker Adds North America Drug Delivery Devices Market Outlook to 2017 2
Shandon Plastic Slide Boxes...
Shandon Cardboard Slide Folders...
... The new Propaq LT is the ... environment--combining the basic parameters of continuous vital ... new design, making it perfect for just ... place. , Light enough to clip on ...
Exxcel Soft ePTFE vascular graft, designed for exceptional kink resistance and crush resistance, maintains a Soft touch for easier handling during peripheral vascular bypass procedures and vascular a...
Medicine Products: