Navigation Links
Binge drinking increases risk of Type 2 diabetes by causing insulin resistance
Date:1/30/2013

Binge drinking causes insulin resistance, which increases the risk of Type 2 diabetes, according to the results of an animal study led by researchers at the Diabetes Obesity and Metabolism Institute at the Icahn School of Medicine at Mount Sinai. The authors further discovered that alcohol disrupts insulin-receptor signaling by causing inflammation in the hypothalamus area of the brain.

The results are published in the January 30 issue of the journal Science Translational Medicine.

"Insulin resistance has emerged as a key metabolic defect leading to Type 2 diabetes and coronary artery disease (CAD)," said Christoph Buettner, MD, PhD, senior author of the study and Associate Professor of Medicine (Endocrinology, Diabetes and Bone Disease). "Someone who regularly binge drinks even once a week, over many years, may remain in an insulin resistant state for an extended period of time, potentially years," said Dr. Buettner.

In this study, researchers treated rats with alcohol for three consecutive days to simulate human binge drinking. A control group received the same amount of calories. Once alcohol was no longer detectable in blood, glucose metabolism was studied through either glucose-tolerance tests or through controlled-insulin infusions. The rats treated with alcohol were found to have higher concentrations of plasma insulin than the control group, suggesting that insulin resistance may have been the cause of the impaired glucose tolerance.

High plasma insulin levels are a major component of the metabolic syndrome, a group of risk factors that occur together and increase the risk for Type 2 diabetes, coronary artery disease, and stroke.

"Previously it was unclear whether binge drinking was associated with an increased risk for diabetes, since a person who binge drinks may also tend to binge eat, or at least eat too much. Our data show for the first time that binge drinking induces insulin resistance directly and can occur independent of differences in caloric intake," said Claudia Lindtner, MD, first author of the study and an Associate Researcher of Medicine, Endocrinology, Diabetes and Bone Disease at the Icahn School of Medicine.


'/>"/>

Contact: Jeanne Bernard
Jeanne.Bernard@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Binge Drinking Common Among U.S. Women, Girls: CDC
2. Strange Food Pairings May Signal Binge Eating: Study
3. Young Binge Eaters Prone to Illicit Drug Use: Study
4. College Students Who Binge Drink Say Theyre Happier
5. Binge drinking college students are happier than their non-binge drinking peers
6. Binge drinking increases the risk of cognitive decline in older adults
7. Rats, like humans, return to drinking once punishment is removed
8. Doctors Often Miss Signs of Problem Drinking in Patients, Study Finds
9. Protective communities may reduce risk of drinking in teens
10. Heavy Drinking, Pot Use Tied to Teen Brain Changes
11. AddictionFreeCanada.com, At a Recent Press Briefing, Offered Solutions to Dangers Caused by Smoking, Drinking and Gambling.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... May 04, 2016 , ... A new collaboration will ... The Duke Clinical Research Institute (DCRI) and analytics leader SAS will provide researchers worldwide ... collected by the Duke University Health System. , The DCRI and SAS share ...
(Date:5/4/2016)... ... 04, 2016 , ... May kicked off with Melanoma Monday , a ... Dr. Ellen Turner is encouraging her patients, as well as residents all around Dallas, ... and health now and in the future. , The dermatology-specific awareness month ends with ...
(Date:5/4/2016)... ... May 04, 2016 , ... ... nutrients that supports cellular and metabolic health. This synergistic combination of omega-3 fatty ... curcumin, along with 150 mg of reduced glutathione and 200 mg of N-Acetylcysteine ...
(Date:5/4/2016)... Plainsboro, NJ (PRWEB) , ... May 04, 2016 ... ... for pharmacists and the pharmacy industry, today announced that it was chosen as ... Purchasing Alliance (APPA) Industry Awards . The awards acknowledge the hard work and ...
(Date:5/4/2016)... ... 04, 2016 , ... AudioEducator is the country's top training ... AudioEducator has lined up some informative training session for the medical coding and ... know-how and practical, easy-to-apply advice. , On Thursday, May 19, AudioEducator will host ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... Pharmaceutical giant Johnson & Johnson has been ... says its talc-based powder products caused ovarian cancer. The ... million in compensatory damages and $50 million in punitive ... , This is the second in a ... same court awarded $72 million to the family of ...
(Date:5/3/2016)... 3, 2016  Specialty Silicone Fabricators is offering ... how a cleanroom works. The free visual aid ... and technology. Chris Mazelin ... company, SSF enthusiastically supports the Science, Technology, Engineering ... the next generation of innovators. We want to ...
(Date:5/3/2016)... 3, 2016  Forté Elements, LLC (Forté) is excited to announce the launch of ... the nutritional needs of recovery for a variety of clinical conditions. Founded in 2013, ... - http://photos.prnewswire.com/prnh/20160502/362548 Logo -  http://photos.prnewswire.com/prnh/20160502/362547LOGO ... ... ...
Breaking Medicine Technology: