Navigation Links
'Bilingual' neurons may reveal the secrets of brain disease
Date:3/18/2011

This press release is available in French.

A team of researchers from the University of Montreal and McGill University have discovered a type of "cellular bilingualism" a phenomenon that allows a single neuron to use two different methods of communication to exchange information. "Our work could facilitate the identification of mechanisms that disrupt the function of dopaminergic, serotonergic and cholinergic neurons in diseases such as schizophrenia, Parkinson's and depression," wrote Dr. Louis-Eric Trudeau of the University of Montreal's Department of Pharmacology and Dr. Salah El Mestikawy, a researcher at the Douglas Mental Health University Institute and professor at McGill's Department of Psychiatry. An overview of this discovery was published in the Nature Reviews Neuroscience journal.

Their results show that many neurons in the brain are able to control cerebral activity by simultaneously using two chemical messengers or neurotransmitters. This mode of communication is known as "cotransmission." According to Dr. Trudeau, "the neurons in the nervous system both in the brain and in the peripheral nervous system are typically classified by the main transmitter they use." For example, dopaminergic neurons use dopamine as a transmitter to communicate important information for many different phenomena such as motivation and learning. The malfunction of these neurons is involved in serious brain diseases such as schizophrenia and Parkinson's. "Our recent research, carried out in part with Dr. Laurent Descarries at the University of Montreal, shows that dopaminergic neurons use glutamate as a second transmitter. That means they are able to transmit two types of messages in the brain, on two time scales: a fast one for glutamate and a slower one for dopamine."

Other research conducted by Dr. Salah El Mestikawy's team at the Douglas Mental Health University Institute observed the same kind of bilingualism in brain neurons that use serotonin, a group of cells that communicate important information for controlling mood, aggression, impulsivity and food intake, and also those that use acetylcholine, an important messenger for motor skills and memory that is unbalanced by Parkinson's disease, antipsychotic drugs and in drug addiction.

Joint studies carried out with their colleague Dr. sa Wallen-Mackenzie at Uppsala University in Sweden and published recently in the Proceedings of the National Academy of Sciences journal suggest that the secretion of glutamate by dopaminergic neurons could, for example, be involved in the behavioural effects of psychostimulants such as amphetamines and cocaine. "We know very little about the role of cotransmission in disease and the regulation of behaviour, however," Dr. Trudeau warned. "That will have to be the subject of future studies."


'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related medicine news :

1. Elsevier Health Middle East announces publication of first bilingual medical title
2. Bilingualism Seems to Boost Brain Power
3. Bilingual People More Adept at Learning Third Language
4. Bilingual benefits reach beyond communication
5. Bilingualism delays onset of Alzheimers symptoms
6. Researchers get $3.3 million grant to investigate language outcomes of bilingual children
7. Bilingualism Might Begin in the Womb
8. Human stem cells transformed into key neurons lost in Alzheimers
9. Learning causes structural changes in affected neurons
10. Neurons work like a chain of dominos to control action sequences
11. Neurons cast votes to guide decision-making
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson Insurance and Financial ... financial preparation services, is providing an update on a charitable event that began ... Rescue is a locally recognized nonprofit that provides shelter and care for animals ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family Medicine's (ABFM) Board ... Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will ... Dr. Puffer’s retirement at the end of 2018. Upon assuming the role of President ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical ... the primary prevention of cardiovascular diseases during the 15th Annual Women’s Health ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
(Date:10/13/2017)... ... 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out ... free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting ... children of all ages; it is a non-competitive, non-timed event, which is all about ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2, 2017  Eli Lilly and Company (NYSE: ... the third quarter of 2017 on Tuesday, October 24, ... that day with the investment community and media to ... conference call will begin at 9 a.m. Eastern time. ... live webcast of the conference call through a link ...
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, ... 2017 earnings conference call and webcast on Friday, November ... a.m. (EDT) and ending at approximately 8:30 a.m. (CDT) ... discussing the company,s 2017 financial performance and guidance for ... opportunities, initiatives to enhance operational performance, and long-range financial ...
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
Breaking Medicine Technology: