Navigation Links
Big data tackles tiny molecular machines
Date:3/14/2014

s open to release the peptides and the molecule expands again to restart the cycle."

Key to the success of DCA is the realization that amino acid mutations represent contacts that co-evolve for specific purposes. The contact maps created by DCA can reveal previously unknown details to model transitions between functional states, like the paddling in FtsH, Onuchic said.

"We can look at the evolutionary tree of these proteins and see which pairs of amino acids changed together. We then assume these are contacts," he said. "Through DCA, Faruck uses a lot of physics to understand when two amino acids can act directly or indirectly, and separate the two. Then we predict how coupled they are, and the higher the probability, the more evidence that these are real contacts."

DCA would do little without the flood of data available since the ability to scan entire genomes became possible, and even commonplace, in recent decades. Advances in the century-old art of crystallography are making better structure-based models available as well.

"Even if the mathematical framework was ready and we had crystallographic data for this motor protein in the 1990s, there weren't enough sequences available until the 2000s," Morcos said. "Now we have all the pieces converging."

He said understanding essential motor proteins in bacteria will be important as researchers begin to apply DCA to advance human health. "For us, the most exciting part is that we're now able to tackle really big systems," Morcos said.


'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. New Per Wickstrom Blog Post Tackles Addiction Myths
2. Healthy Snack Food Brand, Extend Nutrition, Tackles the Junk-Food Giants
3. New Book Tackles HIV/AIDS Risks of Migrant Zimbabwean Youth
4. Dr. Avram Weinberg Tackles Chronic Pain Complaints with New Approach
5. New book tackles the Girl With the Dragon Tattoo
6. Molecular aberration signals cancer
7. Study uncovers molecular keys to invasive bladder cancer
8. Short circuit in molecular switch intensifies pain
9. Molecular nano-spies to make light work of disease detection
10. Research shows molecular, protein targeting therapies may be best treatment for certain lung cancer
11. Molecular Diagnostics Role in Cancer Testing Analyzed in In-demand TriMark Report Published at MarketPublishers.com
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Big data tackles tiny molecular machines
(Date:6/30/2015)... FL (PRWEB) , ... June 30, 2015 , ... According ... doubled from 2007 to 2013 while heroin-related deaths more than tripled in the same ... threat (1). Novus Medical Detox Center , a leading Florida-based drug treatment facility, ...
(Date:6/30/2015)... (PRWEB) , ... June 30, 2015 , ... According to ... received a $3.1 million grant to study how sensory stimuli can be used to ... emphasis on improving care for children with autism, will compare patient experience in a ...
(Date:6/30/2015)... ... June 30, 2015 , ... Lakeview Health, a drug and ... size of its medical staff to further enhance its ability to treat addiction ... practitioners and physician assistants -- now totals 17, compared to 7 in 2013, ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... pending in a federal multidistrict litigation now underway in the U.S. District Court, ... monthly Status Conference. According to the Court’s calendar, that conference has now been ...
(Date:6/30/2015)... ... 30, 2015 , ... Dr. Sammy Masri of Masri Sports Medicine &Wellness, NJ ... the diagnosis and treatment of non-surgical sports and other musculoskeletal injuries for both adults ... athletics and use exercise to stay healthy and active. Dr. Masri seeks to provide ...
Breaking Medicine News(10 mins):Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 2Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 3Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 4Health News:New Study Aims to Determine if Sensory Stimuli can Ease Dental Anxiety in Children, Notes Medical Center Dental Care 2Health News:New Study Aims to Determine if Sensory Stimuli can Ease Dental Anxiety in Children, Notes Medical Center Dental Care 3Health News:Lakeview Health, a Nationally Recognized Drug Rehabilitation Center in Florida, Doubles Size of Medical Staff 2Health News:Progress of Federal Xarelto Lawsuits Pending in Multidistrict Litigation to Be Discussed During July 9th Status Conference 2Health News:Progress of Federal Xarelto Lawsuits Pending in Multidistrict Litigation to Be Discussed During July 9th Status Conference 3Health News:NJ Top Docs Presents Dr. Sammy Masri; Dr. Masri is Now Offering a Wide Range of Services to his Valued Patients 2Health News:NJ Top Docs Presents Dr. Sammy Masri; Dr. Masri is Now Offering a Wide Range of Services to his Valued Patients 3Health News:NJ Top Docs Presents Dr. Sammy Masri; Dr. Masri is Now Offering a Wide Range of Services to his Valued Patients 4Health News:NJ Top Docs Presents Dr. Sammy Masri; Dr. Masri is Now Offering a Wide Range of Services to his Valued Patients 5
... Researchers have discovered that some women carry a genetic ... respond to ovarian stimulating hormones during fertility treatment. The ... devising personalised fertility treatments that could bypass the problem ... told the 26th annual meeting of the European Society ...
... ... based laboratory equipment repair and instrument calibration services company, has been formally approved ... lab., , ... (PRWEB) June 29, 2010 -- Beginning in 2009, the AL-TAR Quality Department ...
... Want to lose ... weight off permanently and enjoy top physical fitness levels? See what Brilliance Weight Loss has to ... (PRWEB) June 29, ... and its customer base, as it continues to gain success with showing people how to ...
... Azmacort and ... an equivalent medication. Many have chosen to write into the People,s Medicine Community to express ... Learn more about the FDA,s decision and connect with other individuals through this special report. ... Westlake Village, CA (PRWEB) ...
... By Randy Dotinga HealthDay Reporter , MONDAY, June ... who take the cholesterol-lowering drugs known as statins are a ... But don,t demand that your doctor prescribe a statin ... for you just yet. The findings aren,t firm enough ...
... immune cell known to cause chronic inflammation in autoimmune ... low back pain associated with herniated discs, according to ... finding implicates the cytokine molecule interleukin-17, and supports the ... role in disc disease, says William J. Richardson, MD, ...
Cached Medicine News:Health News:Study finds why some women are sub-fertile with a poor response to ovarian stimulating hormones 2Health News:Study finds why some women are sub-fertile with a poor response to ovarian stimulating hormones 3Health News:AL-TAR Services, Inc. Laboratory Is Now Accredited For ACLASS Standards 2Health News:Brilliance Weight Loss Takes Dieters Beyond Trendy Low Fat Diets 2Health News:Impact of Azmacort Withdrawal Brought to Light in Medicine Community 2Health News:Impact of Azmacort Withdrawal Brought to Light in Medicine Community 3Health News:Impact of Azmacort Withdrawal Brought to Light in Medicine Community 4Health News:Impact of Azmacort Withdrawal Brought to Light in Medicine Community 5Health News:Statins May Lower Rates of Prostate Cancer Recurrence 2Health News:Surprising find may yield new avenue of treatment for painful herniated discs 2
(Date:6/30/2015)... und KOPENHAGEN, Dänemark, 30. Juni 2015 /PRNewswire/ ... Weltmarktführer der klinischen und kommerziellen Produktion von ... heute bekannt, dass das Unternehmen im Rahmen ... der nordamerikanischen Produktionsanlage in Bothell, ... Einweg-Anlage Bioreactor 6Pack™ komplettiert hat. Die Konfiguration ...
(Date:6/30/2015)... 30, 2015  EnteroMedics Inc. (NASDAQ: ETRM ), ... technology to treat obesity, metabolic diseases, and other gastrointestinal ... offering  of 40,229,886 units. Each unit consists of one ... warrant to purchase one share of common stock, and ... share of common stock, at a purchase price of ...
(Date:6/30/2015)... 2015  Egalet Corporation (Nasdaq: EGLT ... company focused on developing, manufacturing and marketing ... from a Category 3 human abuse liability ... oral oxycodone product candidate in late-stage clinical ... enough to require daily, around-the-clock opioid treatment ...
Breaking Medicine Technology:CMC Biologics baut GMP-Produktionskapazität in den USA aus 2CMC Biologics baut GMP-Produktionskapazität in den USA aus 3EnteroMedics Inc. Announces Pricing of $35.0 Million Public Offering of Common Stock and Warrants 2EnteroMedics Inc. Announces Pricing of $35.0 Million Public Offering of Common Stock and Warrants 3Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 2Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 3Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 4Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 5
... A surgically implanted bone growth stimulator ... EBI OsteoGen surgically implanted bone growth stimulator ... of nonunions when surgery is already planned ... concern. Because the OsteoGen is totally surgically ...
... area contact between grant material and fracture ... long bones., ,Grid-Like Format of Mesh Cathode ... Bone , ,The innovative Mesh Cathode of ... area and a scaffolding effect designed to ...
... Flexible Cystoscope System using EndoSheath Technology ... for urologists in both their hospitals ... CST-2000 flexible cystoscope with the sterile, ... cystoscopy procedures, while minimizing the costs ...
... The PK Plasma-CISE™ (wire electrodes) ... single use devices that produce ... minimal thermal spread and Vapor ... superior hemostasis. The devices provide ...
Medicine Products: