Navigation Links
Big data tackles tiny molecular machines
Date:3/14/2014

s open to release the peptides and the molecule expands again to restart the cycle."

Key to the success of DCA is the realization that amino acid mutations represent contacts that co-evolve for specific purposes. The contact maps created by DCA can reveal previously unknown details to model transitions between functional states, like the paddling in FtsH, Onuchic said.

"We can look at the evolutionary tree of these proteins and see which pairs of amino acids changed together. We then assume these are contacts," he said. "Through DCA, Faruck uses a lot of physics to understand when two amino acids can act directly or indirectly, and separate the two. Then we predict how coupled they are, and the higher the probability, the more evidence that these are real contacts."

DCA would do little without the flood of data available since the ability to scan entire genomes became possible, and even commonplace, in recent decades. Advances in the century-old art of crystallography are making better structure-based models available as well.

"Even if the mathematical framework was ready and we had crystallographic data for this motor protein in the 1990s, there weren't enough sequences available until the 2000s," Morcos said. "Now we have all the pieces converging."

He said understanding essential motor proteins in bacteria will be important as researchers begin to apply DCA to advance human health. "For us, the most exciting part is that we're now able to tackle really big systems," Morcos said.


'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. New Per Wickstrom Blog Post Tackles Addiction Myths
2. Healthy Snack Food Brand, Extend Nutrition, Tackles the Junk-Food Giants
3. New Book Tackles HIV/AIDS Risks of Migrant Zimbabwean Youth
4. Dr. Avram Weinberg Tackles Chronic Pain Complaints with New Approach
5. New book tackles the Girl With the Dragon Tattoo
6. Molecular aberration signals cancer
7. Study uncovers molecular keys to invasive bladder cancer
8. Short circuit in molecular switch intensifies pain
9. Molecular nano-spies to make light work of disease detection
10. Research shows molecular, protein targeting therapies may be best treatment for certain lung cancer
11. Molecular Diagnostics Role in Cancer Testing Analyzed in In-demand TriMark Report Published at MarketPublishers.com
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Big data tackles tiny molecular machines
(Date:10/1/2014)... strongly associated with Alzheimer,s disease; however, researchers are still ... causal agent of the onset and development of the ... beta-amyloid is not harmful when found in isolation but ... to form the so-called amyloid fibrils , "We are ... with multiple ones because each aggregate of peptide, which ...
(Date:10/1/2014)... published today in the Journal of the American ... 50 years with moderate or severe chronic knee pain, ... the University of Melbourne randomly assigned 282 patients (50 ... acupuncture or sham or pretend laser treatment. , ... acupuncturists blinded to laser and sham (inactive) laser acupuncture. ...
(Date:10/1/2014)... Physical Sciences Research Council (EPSRC) will focus on ... systems which run, for example, manufacturing plants, power ... , The research will help understand and ... systems behind our critical national infrastructure. , ... (RITICS), based at Imperial College London, is co-ordinating ...
(Date:10/1/2014)... 2014) Despite a policy focus on expanding ... this vulnerable population continues to have significant dental ... Journal of the American Dental Association , researchers ... University School of Dental Medicine report on the ... oral care provided by caregivers to adults with ...
(Date:10/1/2014)... October 01, 2014 Familylifeinsurancequotes.org has ... life insurance for senior citizens. , Senior citizens ... will now sell coverage to seniors who are over ... be purchased without taking a medical examination. , Term ... online and senior clients can qualify. Having life insurance ...
Breaking Medicine News(10 mins):Health News:Laying siege to beta-amyloid, the key protein in Alzheimer's disease 2Health News:Study finds acupuncture does not improve chronic knee pain 2Health News:£2.5 million to recognize and reduce cyber-attack threats to critical infrastructure 2Health News:To improve oral health of adults with developmental disabilities, support caregivers 2Health News:To improve oral health of adults with developmental disabilities, support caregivers 3Health News:Affordable Term Life Insurance - Senior Citizens Can Qualify for Coverage! 2
... ... product development. , ... Toronto, ON (Vocus) March 29, 2010 -- Therapure Biopharma Inc. today announced a fill/finish ... Under the terms of the agreement, Therapure will provide custom fill/finish services for a ...
... ... nonprofit organization that engages hundreds of thousands of students into humanitarian ... collaborative management of tasks and workflow. Absolute’s Chief Operating Officer reports ... operations transparency, thanks to Wrike’s unique project collaboration features. , ...
... enrolled in therapeutic clinical research trials shows that they don,t ... participation, nor do they feel they are genuinely involved in ... Yoram Unguru, M.D., an associate faculty member at the Johns ... 29 in the journal Pediatrics . While an ...
... combination destroys precancerous colon polyps with no effect on normal ... cancer, a team of scientists at The University of Texas ... edition of the journal Nature . The regimen, ... cancer tissue in the lab, appears to address a problem ...
... rats, the more fattening foods they ate, the more they wanted ... they,d like to eat less but feel almost powerless to stop ... too true. , The theory stems from a study in rats. ... of bacon, pound cake, candy bars and other junk food, the ...
... Unethical job ... wage jobs in Canada. Sometimes these carers do not even have a job when they ... one Vancouver-based business owner says problems could persist. , ... (PRWEB) March 28, 2010 -- New federal legislation coming into force ...
Cached Medicine News:Health News:Therapure Biopharma Inc. signs fill/finish contract with Kane Biotech Inc. 2Health News:COO Becomes 75% More Effective in Tracking Delegated Tasks 2Health News:COO Becomes 75% More Effective in Tracking Delegated Tasks 3Health News:Childhood cancer patients enrolled in clinical trials need clearer communication about their role 2Health News:Childhood cancer patients enrolled in clinical trials need clearer communication about their role 3Health News:Paired drugs kill precancerous colon polyps, spare normal tissue 2Health News:Paired drugs kill precancerous colon polyps, spare normal tissue 3Health News:Junk Food 'Addiction' May Be Real 2Health News:Junk Food 'Addiction' May Be Real 3Health News:Exploitation of Overseas Nannies and Caregivers Could Continue Despite New Canadian Immigration Laws 2Health News:Exploitation of Overseas Nannies and Caregivers Could Continue Despite New Canadian Immigration Laws 3
(Date:10/2/2014)... 1, 2014 The global high content screening ... the ,Threat of Obsolescence, wherein technologies as well as ... and biotechnology companies as well as academic and government ... as a powerful research tool in drug discovery. The ... in the high content screening market. In high content ...
(Date:10/1/2014)... , Oct. 1, 2014  Dyadic International, Inc. ... patented and proprietary technology used to develop and ... bio-based chemicals, biopharmaceuticals, and industrial enzymes industries, today ... from Abengoa Bioenergy for commercial scale production of ... into ethanol, developed under Abengoa,s license agreement with ...
(Date:10/1/2014)... SAN DIEGO , Oct. 1, 2014 /PRNewswire/ ... cell-free molecular diagnostics, announced today that Eli ... Sloan Kettering Cancer Center (MSK), presented clinical data ... Trovagene,s precision cancer monitoring platform for the determination ... from a liquid biopsy.  The results were presented ...
Breaking Medicine Technology:High Content Screening Market by Instruments (Cell Imaging and Analysis System), by Applications (Primary and Secondary Screening, Target Identification and Validation, Toxicity Studies, Compound Profiling), Software & Services - Global Forecasts to 2High Content Screening Market by Instruments (Cell Imaging and Analysis System), by Applications (Primary and Secondary Screening, Target Identification and Validation, Toxicity Studies, Compound Profiling), Software & Services - Global Forecasts to 3Dyadic International Reports Licensing Payment For Commercial-Scale Production Of C1-Based Cellulase Enzymes 2Dyadic International Reports Licensing Payment For Commercial-Scale Production Of C1-Based Cellulase Enzymes 3Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 2Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 3Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: