Navigation Links
Big data tackles tiny molecular machines
Date:3/14/2014

tly moving proteins, he said, "but functional proteins, big protein complexes and molecular machines have multiple conformations.

"Computational models are also useful, but to understand the full dynamics of these large proteins, where a lot of the interesting biology takes place, we have to supplement them with more information," he said.

That information comes from direct coupling analysis (DCA), a statistical tool developed by Morcos and Onuchic with colleagues at the University of California, San Diego, and the Pierre and Marie Curie University. DCA looks at the genetic roots of proteins to see how amino acids the "beads" in the unfolded protein strands -- co-evolved to influence the way a protein folds. Each bead carries an intrinsic energy that contributes to the strand's distinct energy landscape, which dictates how it folds into its functional state.

Even after they fold, proteins are in perpetual motion, acting as catalysts for countless bodily functions. They can combine into larger molecular machines that grab other molecules, "walk" cargoes within a cell or cause muscles to contract.

One such biomachine is FtsH, a membrane-bound molecule in E. coli made of six protein copies that form two connected hexagonal rings. The molecule attracts and degrades misfolded proteins and other cellular detritus, pulling them in through one ring, which closes like the shutter of a camera and traps the proteins. They are cut apart as they exit through the other ring.

Through molecular simulations using structure-based models and the discovery via DCA of likely couplings in the genetic source of the proteins, the Rice team found evidence to support the hypothesis of a "paddling" mechanism in the molecule that Morcos described as a collapse of the two rings once trash found its way inside.

"First the ring pore closes to grab the protein; then the molecule flattens," he said. "Then when the motor is flat, the ring
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. New Per Wickstrom Blog Post Tackles Addiction Myths
2. Healthy Snack Food Brand, Extend Nutrition, Tackles the Junk-Food Giants
3. New Book Tackles HIV/AIDS Risks of Migrant Zimbabwean Youth
4. Dr. Avram Weinberg Tackles Chronic Pain Complaints with New Approach
5. New book tackles the Girl With the Dragon Tattoo
6. Molecular aberration signals cancer
7. Study uncovers molecular keys to invasive bladder cancer
8. Short circuit in molecular switch intensifies pain
9. Molecular nano-spies to make light work of disease detection
10. Research shows molecular, protein targeting therapies may be best treatment for certain lung cancer
11. Molecular Diagnostics Role in Cancer Testing Analyzed in In-demand TriMark Report Published at MarketPublishers.com
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Big data tackles tiny molecular machines
(Date:3/27/2015)... Dallas, TX (PRWEB) March 27, 2015 ... Landscape – Germany” is an essential source of ... and reimbursement landscape in Germany. Germany’s increasingly elderly ... drivers of its pharmaceutical market. In 2013, the ... expected to increase at Compound Annual Growth Rate ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 DrugDev announced ... (Liss) Easy was named to the 2015 Philadelphia Business ... 40 list spotlights 40 dynamic, up-and-coming leaders less than ... community involvement. Winners are honored at an awards program ... the Philadelphia Business Journal. , Lyn Kremer, Publisher of ...
(Date:3/27/2015)... USA (PRWEB) March 27, 2015 According ... rates of newborns born with Neonatal Abstinence Syndrome (NAS) ... NAS will undergo the painful withdrawal process for a ... body tremors, excessive crying, diarrhea, and vomiting. The condition ... undergoing drug and alcohol addiction treatment (and employing medically ...
(Date:3/27/2015)... California’s ongoing worst ever drought, and ... the United States Northeast, are both manifestations of the ... is creating changes in the atmosphere’s “energy balance,” according ... NASA researcher, speaking on the Sharon Kleyne Hour™ Power ... a warmer and dryer global climate but also greater ...
(Date:3/27/2015)... To address their number one lawn care question ... filming this video to explain the complicated dynamics between the ... often expected to thrive in, be it in dense building ... survive. Anytime a sun-loving plant is put in the shade ... homeowners try to amend this issue by applying large quantities ...
Breaking Medicine News(10 mins):Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 2Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 3Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 4Health News:DrugDev Founder Melissa Easy is 2015 Philadelphia Business Journal 40 Under 40 Honoree 2Health News:In Florida Only 10% of Pregnant Mothers Are Referred to Drug Rehab Despite Testing Positive for Narcotics 2Health News:California Drought, Boston Blizzards Both Attributed to Global Climate Change Reports Climatologist to Fresh Water Advocate 2Health News:California Drought, Boston Blizzards Both Attributed to Global Climate Change Reports Climatologist to Fresh Water Advocate 3Health News:For Spring Turf Planting Season, Super-Sod Created a New How-To Video Entitled "Two Views on Shade and Turf" 2
... Va. The National Institute of Dental and Craniofacial ... (AADR) a multi-year Bloc Travel Grant in the amount ... Each year, this award will assist approximately 50 students ... Dental Research (IADR) General Session & Exhibition for the ...
... With the nation,s economic crisis contributing to greater workplace ... be more important than ever. , Unfortunately, the approach ... is flawed and unlikely to produce the best outcomes ... according to a Florida State University College of Medicine ...
... "Despite our concerns about the ill-advised proposal to ... by the VA for service-connected health conditions, Vietnam ... President Obama for its generosity in assisting all ... President John Rowan. "VVA joins fellow veterans, service ...
... IRVINE, Calif., March 17 Frost & Sullivan ... in the Global Diabetes Diagnostics Market to Epinex for ... . Frost & Sullivan is an internationally renowned market ... years of history in the global marketplace. The ...
... March 17 Shands HealthCare has selected the ... key component of its ongoing effort to improve ... healthcare system affiliated with the University of ... in Gainesville and Jacksonville. It includes eight Shands ...
... largest water efficiency conference Oct. 7-9 in Las Vegas , ... Denver ... water resources, the American Water Works Association (AWWA), the authoritative ... WaterSmart Innovations Conference and Exposition , Oct. 7-9, 2009, in Las Vegas., ...
Cached Medicine News:Health News:Researcher wins $2.6 million grant for depression care study 2Health News:Researcher wins $2.6 million grant for depression care study 3Health News:VVA Praises President's Budget Submission for Veterans Affairs; Condemns Ill-advised Revenue Proposal 2Health News:Frost and Sullivan Picks Epinex for Diabetes Research Award 2Health News:Shands HealthCare Selects Micromedex CareNotes System from Thomson Reuters to Improve Patient Education 2Health News:Shands HealthCare Selects Micromedex CareNotes System from Thomson Reuters to Improve Patient Education 3Health News:AWWA partners with WaterSmart Innovations conference 2
(Date:3/27/2015)... Report Details  New study shows ... What does the future hold for top companies ... new report shows you potential revenues to 2025, assessing ... 242-page report provides 185 tables, charts, and graphs. Discover ... future market prospects. Our new study lets you assess ...
(Date:3/27/2015)... 27, 2015 The International Myeloma Foundation (IMF) ... while working toward prevention and a cure – today ... a federal resolution (H. Res. 174) that supports the ... Multiple Myeloma Awareness Month." Currently there are ... more than 110,000 new cases are diagnosed yearly, according ...
(Date:3/27/2015)... DALLAS , March 27, 2015 ... Review, H1 2015" therapeutic market research report of ... to its online business intelligence library. ... comprehensive information on the therapeutic development for Visceral ... therapeutics assessment by drug target, mechanism of action ...
Breaking Medicine Technology:Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 2Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 3Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 4Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 5Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 6Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 7The International Myeloma Foundation (IMF) Secures the Introduction of a Federal Resolution Recognizing March 2015 as "National Multiple Myeloma Awareness Month" 2Visceral Pain Pipeline Review H1 2015 Market Research Report 2Visceral Pain Pipeline Review H1 2015 Market Research Report 3Visceral Pain Pipeline Review H1 2015 Market Research Report 4
... 2012  Michael Volkov has joined the law firm of ... will be resident in the firm,s Alexandria, Va. and ... and veteran white collar defense attorney will provide compliance, ... broad range of issues, including the Foreign Corrupt Practices ...
... today that their applications for Transvaginal Mesh cases and ... company began funding plaintiffs for Mesh cash advances beginning ... industry do not fund Vaginal Mesh or Hernia Mesh ... is one of the few companies now offering plaintiffs ...
Cached Medicine Technology:Veteran FCPA and White Collar Attorney Michael Volkov Joins LeClairRyan 2Vaginal Mesh and Kugel Hernia Mesh Case Applications for Lawsuit Funding on the Rise at Legal-Bay Settlement Funding 2
Stryker's 40-liter insufflator provides superior performance with unprecedented safety and reliability....
Bipolar forceps...
... INFORM HPV allows the pathologist to visualize the ... allows testing on a choice of sample types: ... HPV cocktails utilize proprietary probe formulations. The Family ... genotypes 16, 18, 31, 33, 35, 39, 51, ...
... Common primary human fungal pathogens ... spp., opportunistic fungal pathogens, including ... cerevisiae, Acremonium, Coccidioides immitis, Histoplasma ... and Pneumocystis carinii. The (1-3)--D-glucan ...
Medicine Products: