Navigation Links
Big data tackles tiny molecular machines
Date:3/14/2014

HOUSTON (March 13, 2014) Open, feed, cut. Such is the humdrum life of a motor molecule, the subject of new research at Rice University, that eats and excretes damaged proteins and turns them into harmless peptides for disposal.

The why is obvious: Without these trash bins, the Escherichia coli bacteria they serve would die. And thanks to Rice, the how is becoming clearer.

Biophysicists at Rice used the miniscule machine a protease called an FtsH-AAA hexameric peptidase as a model to test calculations that combine genetic and structural data. Their goal is to solve one of the most compelling mysteries in biology: how proteins perform the regulatory mechanisms in cells upon which life depends.

The Rice team of biological physicist Jos Onuchic and postdoctoral researchers Biman Jana and Faruck Morcos published a new paper on the work this month for a special issue of the Royal Society of Chemistry journal, Physical Chemistry Chemical Physics.

The special issue edited by Rice biophysicist Peter Wolynes and Ruth Nussinov, a researcher at the National Cancer Institute in Frederick, Md., and a professor at the Sackler School of Medicine at Tel Aviv University, pulls together current thinking on how an explosion of data combined with ever more powerful computers is bringing about a second revolution in molecular biology.

The paper describes the Onuchic group's first successful attempt to feed data through their computational technique to describe the complex activity of a large molecular machine formed by proteins. Ultimately, understanding these machines will help researchers design drugs to treat diseases like cancer, the focus of Rice's Center for Theoretical Biological Physics.

"Structural techniques like X-ray crystallography and nuclear magnetic resonance have worked quite well to help us understand how smaller proteins function," Onuchic said. X-rays only take snapshots of constan
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. New Per Wickstrom Blog Post Tackles Addiction Myths
2. Healthy Snack Food Brand, Extend Nutrition, Tackles the Junk-Food Giants
3. New Book Tackles HIV/AIDS Risks of Migrant Zimbabwean Youth
4. Dr. Avram Weinberg Tackles Chronic Pain Complaints with New Approach
5. New book tackles the Girl With the Dragon Tattoo
6. Molecular aberration signals cancer
7. Study uncovers molecular keys to invasive bladder cancer
8. Short circuit in molecular switch intensifies pain
9. Molecular nano-spies to make light work of disease detection
10. Research shows molecular, protein targeting therapies may be best treatment for certain lung cancer
11. Molecular Diagnostics Role in Cancer Testing Analyzed in In-demand TriMark Report Published at MarketPublishers.com
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Big data tackles tiny molecular machines
(Date:3/5/2015)... York, New York (PRWEB) March 05, 2015 ... of men who allegedly suffered heart attacks, strokes and ... prescription low testosterone therapies continue to move forward in ... Court, Northern District of Illinois. According to a Case ... set forth procedures for the use of master pleadings ...
(Date:3/5/2015)... 2015 The Maricopa Community Colleges ... to the Arizona economy each year, according to a ... Economic Value of Maricopa County Community College District, summarizes ... district in fiscal year 2013-2014. , The analysis ... (EMSI), an organization that specializes in providing economic impact ...
(Date:3/5/2015)... Auburn, CA (PRWEB) March 05, 2015 ... and clinical solutions for the population health management arena, ... recently enhanced case management software, ACUITY Advanced Care™ (ACUITY) ... user interface, improved performance and the advantages of automation. ... 12:30 p.m. ET, will be led by Jeff Frater, ...
(Date:3/5/2015)... 05, 2015 Califia Farms , ... the natural products coffee drinks category[1], today unveils its ... West in Anaheim, Calif. Concentrated Cold Brew (CCB) ... Café, which democratizes the next wave of the coffee-taste ... need to become their own baristas. , Califia ...
(Date:3/5/2015)... March 05, 2015 For PASCHA Chocolate, ... most essential ingredients, the robust flavor of the cacao ... PASCHA Chocolate is free from peanuts, nuts, dairy, ... PASCHA's offering March 6th- 8th at Expo West., ... PASCHA Chocolate has broken new ground with their New ...
Breaking Medicine News(10 mins):Health News:Testosterone Lawsuits Move Forward, as Bernstein Liebhard LLP Comments on Most Recent Order Issued in Federal Litigation 2Health News:Testosterone Lawsuits Move Forward, as Bernstein Liebhard LLP Comments on Most Recent Order Issued in Federal Litigation 3Health News:Testosterone Lawsuits Move Forward, as Bernstein Liebhard LLP Comments on Most Recent Order Issued in Federal Litigation 4Health News:Maricopa Community Colleges Add $7.3 Billion to Local Economy Annually 2Health News:Maricopa Community Colleges Add $7.3 Billion to Local Economy Annually 3Health News:Complimentary Webinar to Explore Enhanced Version of Premier Case Management Software 2Health News:Complimentary Webinar to Explore Enhanced Version of Premier Case Management Software 3Health News:Califia Farms Personalizes At-Home Coffee Experience with the Launch of Concentrated Cold Brew Coffee 2Health News:Califia Farms Personalizes At-Home Coffee Experience with the Launch of Concentrated Cold Brew Coffee 3Health News:Califia Farms Personalizes At-Home Coffee Experience with the Launch of Concentrated Cold Brew Coffee 4Health News:PASCHA Allergen Free Organic Chocolate to Appear at Natural Products Expo West March 6-8, 2015 2
... sign of severe asthma, which means that healthcare professionals ... complaints. Furthermore, more severe asthma appears to be more ... Sahlgrenska Academy,s Krefting Research Centre. Published in the ... study included 30,000 randomly selected participants from the west ...
... Biochemical Engineering Conference is the premier venue for unveiling ... The primary goal of this international conference has always ... engineers from diverse backgrounds to share insights on how ... engineering. As it enters its fourth decade, BME XVII ...
... HealthDay Reporter , MONDAY, Dec. 20 (HealthDay News) -- ... study finds that infants breast-fed for six months or longer, ... compared to bottle-fed tots, according to a new study. ... its positive benefits," said study leader Wendy Oddy, a researcher ...
... Ellin Holohan HealthDay Reporter , FRIDAY, Dec. 17 ... better known as heartburn, is not much of a risk ... research. "It,s a rare cancer," said study author ... of Michigan department of internal medicine. "About 1 in ...
... Dec. 20 (HealthDay News) -- ,Tis the season to be jolly, ... to take care of yourself during the holiday rush. While ... other tasks associated with the season, you need to take steps ... health, said Dr. Gary Kaplan, founder of the Kaplan Center for ...
... , SATURDAY, Dec. 18 (HealthDay News) -- The ... for people with chronic pain or other persistent health conditions ... them at risk for missed doses and even medication errors, ... advance planning can ensure safe and effective medication use over ...
Cached Medicine News:Health News:Nasal congestion can mean severe asthma 2Health News:Biochemical and Molecular Engineering XVII Conference 2Health News:Biochemical and Molecular Engineering XVII Conference 3Health News:Do Breast-Fed Baby Boys Grow Into Better Students? 2Health News:Do Breast-Fed Baby Boys Grow Into Better Students? 3Health News:For Most, Chronic Heartburn Not a Big Risk for Esophageal Cancer 2Health News:For Most, Chronic Heartburn Not a Big Risk for Esophageal Cancer 3Health News:Hectic Holiday Pace Can Upset Medication Schedule 2
(Date:3/5/2015)... According to a new market research report ... by Type (Invasive, Minimally Invasive, Non-Invasive), by End-User (Hospitals, ... Analysis & Global Forecast to 2019" , the global ... Million by 2019 from $887.8 Million in 2014, and ... during the forecast period. Browse 111 ...
(Date:3/5/2015)... Ascendis Pharma A/S, a clinical stage ... to address significant unmet medical needs, today announced ... 2015 conference being held at the San Diego ... Thursday, March 5, 2015 during the Pediatric Endocrinology—Clinical/Translational ... and are titled: TransCon ...
(Date:3/5/2015)... March 5, 2015  MGC Diagnostics Corporation (NASDAQ: ... company, today reported financial results for the first ... 2015 first quarter domestic equipment, supplies and accessories ... $3.7 million in the 2014 first quarter.  During ... or $338,000 in revenue, compared to 14 accounts, ...
Breaking Medicine Technology:Hemodynamic Monitoring Systems Market Worth $1,107.4 Million by 2019 2Hemodynamic Monitoring Systems Market Worth $1,107.4 Million by 2019 3Hemodynamic Monitoring Systems Market Worth $1,107.4 Million by 2019 4Ascendis Pharma to Present at ENDO 2015 2MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 2MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 3MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 4MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 5MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 6MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 7MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 8MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 9MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 10MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 11MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 12
... designed to travel a full 120 degrees, from ... wherever you release the rotating hand grip locking ... the handle with no need to ever go ... of system was designed to mimic the natural ...
Designed for Bariatric usage. Prevents arm or leg dropout during surgical procedures. Dimensions are 16"Lx10"H come in pairs. Optional gel pad available (BD2245)...
Designed to prevent arm or legs from dropouts during surgical procedures. Dimensions are 8"H x16"L. These come as pairs. Optional gel pads(BD2245)....
... Corporation offers a quality line ... to adults. Armboard covers are ... assuring easy cleaning while reducing ... Choose from three options: Disposable ...
Medicine Products: