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Beyond liver transplants: Acutely damaged livers may be repaired via transplanted hepatocytes
Date:2/1/2010

also analyzed hepatic stellate cell (HSC) activation and matrix metalloproteinase expression (MMP2). They found that HCS activation, which is crucial in liver repair after hepatic damage and plays a role in hepatocyte engraftment, was prolonged, but declined after four weeks.

"This suggests that prolonged activation of HSC in acute hepatic injury is beneficial to the proliferation of transplanted cells," commented Dr. Chang.

The researchers also noted that the expression and activity of MMP2 genes were "consistent with the kinetics of HSC activation."

"This is an interesting model where massive liver cell death is imposed over a background where the native liver fails to regenerate," said section editor Dr. Stephen Strom, professor in the Division of Cellular and Molecular Pathology at the University of Pittsburgh. "These are important pre-clinical studies because of the similarities of this model to Acute Liver Failure (ALF) in human patients. The enhanced proliferation of donor cells following transplantation helps to explain why the transplantation of even relatively small numbers of hepatocytes can reverse liver failure."


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Contact: Dr. Mei-Hwei Chang
changmh@ntu.edu.tw
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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