Navigation Links
Beyond liver transplants: Acutely damaged livers may be repaired via transplanted hepatocytes

Tampa, Fla. (Feb. 01, 2010) A research team from the National Taiwan University Hospital has evaluated the efficiency of transplanted hepatocyte (liver) cells in animal models severely damaged by two kinds of chemical toxicity to see whether and how transplanted hepatocytes were able to efficiently repopulate the toxin-induced, severely damaged livers. The results of this study are published in the current double issue of Cell Transplantation (18:10/11) and are freely available on-line at .

The study was carried out in the on-going effort to evaluate hepatocyte transplantation as an alternative to liver transplantation, not only because of the current shortage of liver donors for transplantation, but also because successful cell transplantation is simpler, less invasive and less expensive than organ (i.e., liver) transplantation.

The researchers found that animal model of livers with damage induced from combined retrosine-plus-D-galactosamine (as opposed to animals infused with single toxins) were subject to "massive repopulation of the liver by transplanted hepatocyte cells and hepatocyte growth factor genes."

"We observed rapid infiltration of transplanted hepatocytes into the necrotic and inflammatory hepatic parenchyma within 24 hours of the R+D-gal treated liver, but not the D-gal alone or R-alone treated livers," reported corresponding author Dr. Mei-Hwei Chang. "This result suggests that the higher proliferative activity of transplanted hepatocytes (as compared to host hepatocytes) take over regeneration signals and proliferate. This finding is clinically important because hepatocyte growth factor (HGF) and levels of transforming growth factor-a (TGF-a) which are known to stimulate cell proliferation - are strongly elevated in patients with acute liver failure." Post-hepatocyte transplantation, the researchers also analyzed hepatic stellate cell (HSC) activation and matrix metalloproteinase expression (MMP2). They found that HCS activation, which is crucial in liver repair after hepatic damage and plays a role in hepatocyte engraftment, was prolonged, but declined after four weeks.

"This suggests that prolonged activation of HSC in acute hepatic injury is beneficial to the proliferation of transplanted cells," commented Dr. Chang.

The researchers also noted that the expression and activity of MMP2 genes were "consistent with the kinetics of HSC activation."

"This is an interesting model where massive liver cell death is imposed over a background where the native liver fails to regenerate," said section editor Dr. Stephen Strom, professor in the Division of Cellular and Molecular Pathology at the University of Pittsburgh. "These are important pre-clinical studies because of the similarities of this model to Acute Liver Failure (ALF) in human patients. The enhanced proliferation of donor cells following transplantation helps to explain why the transplantation of even relatively small numbers of hepatocytes can reverse liver failure."


Contact: Dr. Mei-Hwei Chang
Cell Transplantation Center of Excellence for Aging and Brain Repair

Related medicine news :

1. Radiologists encouraged to look beyond cancer for clinically unseen diseases
2. New Pharmacys Owners Go Beyond Your Prescription
3. Pure & Natural: Introducing an Effective, Healthy Approach to Personal Care and Beyond
4. Video: Beyond the Red Door: Gildas Club Worldwide and DKNY Host Successful Benefit Event
5. Banfield, The Pet Hospital(R) and Meals On Wheels Association of America(R) Feed Hungry Pets During the Holidays and Beyond
6. GLOBESCAN Survey for the BEYOND GDP Conference, European Parliament, Nov. 19th and 20th
7. 10 Cities to Participate in Live Well! Life Beyond Cancer Program Sponsored by The Wellness Community and the Lance Armstrong Foundation
8. Ashley Forms Partnership With Roger Burgess and ProCare Rx to Carry Gotham Banner into 2008 and Beyond
9. Fourth Annual James E. Marshall OCD Foundation Beyond Beauty Dinner to Honor E. Scott Beattie, Chairman and CEO, Elizabeth Arden, Inc. and Charles H. Townsend, President and CEO, Conde Nast Publications
10. Michigan Kidney Patient Goes Above and Beyond to Help His Community - Awarded National DPC Hero Award
11. Legislative and Regulatory Outlook - 2009 and Beyond for Pharma, Biotech Players
Post Your Comments:
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder ... of ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership ... rules. It also provides a forum to network with elder law attorneys nationwide,” said ...
(Date:10/13/2017)... LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for care ... is the 90-day elimination period, when the family pays for care, is often waived, ...
(Date:10/13/2017)... ... , ... Ellevate Network, the leading network for professional women, brought together some ... at their inaugural Summit in New York City in June. The event was livestreamed ... over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has ... least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a ... centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that ...
(Date:10/13/2017)... ... 2017 , ... Coveros, a leader in agile coaching services ... by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile Transformation ... Agile methodologies in a consistent and high value manner across CMS programs. Coveros ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... 4, 2017  According to the Centers for Disease Control and Prevention ... . PhysicianOne Urgent Care is helping communities across Massachusetts ... , by offering no-cost* flu shots through the end of the month. ... health insurance regulations. ... to get a flu shot is by the end of October, according ...
(Date:10/2/2017)... Mich. , Oct. 2, 2017 Diplomat ... 8th Day Software and Consulting, LLC , and ... 8th Day Software, based in Tennessee ... LLC. 8th Day expands EnvoyHealth,s service offerings for health ... development. "In an ...
(Date:10/2/2017)... Fla. , Oct. 2, 2017  AllianceRx Walgreens ... company formed by Walgreens and pharmacy benefit manager Prime ... its new brand, which included the unveiling of new ... , as well as at a few other ... the new brand to patients, some of whom will ...
Breaking Medicine Technology: