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Beyond Alzheimer's: Research explores hippocampal sclerosis
Date:2/9/2011

LEXINGTON, Ky. (Feb. 9, 2011) - The population of aged persons worldwide is expanding rapidly, and it is becoming increasingly clear that there are many different diseases that affect the minds of these individuals. Researchers at the University of Kentucky are breaking new ground in the ongoing project of identifying and defining those diseases most likely to affect an aged population. Dr. Peter Nelson of the University of Kentucky Sanders-Brown Center on Aging is the lead author on a paper soon to be published in the journal BRAIN; the paper deals with the little-understood but serious condition hippocampal sclerosis (HS-AGING). He is also the recipient of a newly approved grant from the National Institutes of Health (NIH) to conduct a study of HS-AGING genetics.

Many different diseases may produce symptoms of dementia - defined as cognitive decline and impaired memory - in aged persons. Although Alzheimer's disease is probably the most recognized cause of dementia, HS-AGING also causes serious cognitive impairment in older adults. In those who live to a very advanced age (beyond the age of 95) HS-AGING is roughly as prevalent as Alzheimer's.

It is important for physicians and scientists to understand the unique pathology of HS-AGING, and to be able to differentiate it from other diseases, as it is only by making an accurate diagnosis that clinicians can hope to treat people who present with signs of cognitive decline.

Nelson, a neuropathologist, analyzed autopsy data from 1,100 individuals, each with substantial clinical data available from before death. The long-term clinical information was obtained through the University of Kentucky Alzheimer's Disease Center, the Nun Study and the Georgia Centenarian Study (all autopsies were performed at the University of Kentucky). The large numbers of patients and the high quality of the data enabled the research team to gather new clues about the prevalence and impact of HS-AGING.<
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Contact: Allison Elliott
allison.elliott@uky.edu
University of Kentucky
Source:Eurekalert

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