Navigation Links
Bevacizumab offers no benefit for newly diagnosed glioblastoma, MD Anderson-led study finds
Date:2/19/2014

HOUSTON The angiogenesis inhibitor bevacizumab (Avastin) failed to increase overall survival (OS) or statistically significant progression-free survival (PFS) for glioblastoma patients in the frontline setting, according to a study led by researchers at The University of Texas MD Anderson Cancer Center.

The study appears in the New England Journal of Medicine, and was first presented on the plenary session of the American Society of Clinical Oncology 2013 Annual Meeting by Mark Gilbert, M.D., professor in MD Anderson's Department of Neuro-Oncology.

Glioblastoma is both the most common and lethal form of brain cancer. More than 12,000 people will be diagnosed with the disease in 2013, with an average survival rate of less than 18 months, said Gilbert.

Bevacizumab works as a monoclonal antibody against VEGF-A, which is produced by glioblastoma to stimulate blood vessel growth. The angiogenesis inhibitor first showed promise in glioblastoma as clinicians reported positive results treating the disease under approved compassionate use.

Numerous institutional studies then found similar results: a 35-40 percent objective response rate, or tumor shrinkage, of more than 50 percent, and a six-month PFS rate in the mid-30 percent, said Gilbert, the study's senior author. With those findings, in May 2009, the FDA granted an accelerated registration of bevacizumab in the second-line setting.

However, before this trial, no randomized, double-blind studies with the drug in glioblastoma had been conducted.

"Obviously, glioblastoma is a cancer with too few effective therapies," said Gilbert, who also holds the Blanche Bender Professorship in Cancer Research. "When we launched this study, those in the field of brain cancer both the scientific and patient communities -- were excited. Bevacizumab recently received approval in the second-line (recurrent disease) setting, and we knew some physicians were already giving
'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Bevacizumab (Avastin) fails to improve survival for newly diagnosed glioblastoma patients
2. Phase II trial of Bevacizumab (Avastin) in locally advanced cervical cancer promising
3. Researchers detail possible resistance mechanisms of colorectal cancer to bevacizumab (Avastin)
4. Brain cancer survival improved following FDA approval of bevacizumab, Mayo study finds
5. Test helps target glioblastoma patients most likely to benefit from bevacizumab
6. Bevacizumab offers no benefit for newly diagnosed glioblastoma, M.D. Anderson-led study finds
7. Study finds glioblastoma patients treated with bevacizumab experience reduced cognitive function and quality of life
8. Time to tumor growth helps predict survival benefit of Bevacizumab for patients with metastatic colorectal cancer
9. Innovating for the Global South: New book offers practical insights
10. Fruit fly microRNA research at Rutgers-Camden offers clues to aging process
11. NIH study offers insight into why cancer incidence increases with age
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... CO (PRWEB) August 21, 2014 Aspen Advisors, ... been selected as one of Modern Healthcare’s Best Places ... program recognizes employers in the healthcare industry for creating workplaces ... Results are solely based on employee responses to an employee ... year that Aspen has been named a “Best ...
(Date:8/21/2014)... by T-type calcium channels in the thalamic reticular ... calcium. These channels enable thalamic reticular nucleus neurons ... enter a hyper-excited state. , In order to ... seizures, the researchers conducted an experiment to induce ... to delete the T-type calcium channel CaV3.3. The ...
(Date:8/21/2014)... to researchers at the University of Montreal, the regions ... role as we train our bodies, movements and, critically, ... While researchers knew that sleep helped us the learn ... why. "The subcortical regions are important in information consolidation, ... consolidation level is measured after a period of sleep, ...
(Date:8/21/2014)... Bedros Keuilian’s Annual Fitness Business Summit is considered the ... people already earning seven-figure incomes. But his annual Fit ... to the owners of Keuilian’s own international fitness boot camp ... Boot Camp World Conference will also be attended by 50 ... or are struggling with their own boot camp businesses. ...
(Date:8/21/2014)... Hunhu Healthcare, Inc. , a Minneapolis-based ... it has entered into a licensing agreement with Mayo ... predictive analytics for recruiting, leveraging and managing its solution ... Michael Emerson , co-founder and CEO of Hunhu Healthcare, ... technology used in what he calls a social wellness ...
Breaking Medicine News(10 mins):Health News:Modern Healthcare Names Aspen Advisors Among the Top 100 Employers in the Healthcare Industry for a Fourth Consecutive Year 2Health News:Learning to play the piano? Sleep on it! 2Health News:Fitness Boot Camp Founder Offers Fifty Scholarships to Fit Body Boot Camp World Conference 2Health News:Fitness Boot Camp Founder Offers Fifty Scholarships to Fit Body Boot Camp World Conference 3Health News:Hunhu Healthcare Enters into Licensing Agreement with Mayo Clinic 2
... have discovered a second gene that causes Alagille syndrome, ... many organs.// , This finding may have broader ... Hospital team had earlier discovered the first gene associated ... mutations in the NOTCH 2 gene were linked to ...
... 9,000 Danish residents revealed that a specific mutation in the ... breast cancer in her lifetime. The study, which was the ... the cancer risk associated with it, in the general population, ... Journal of Clinical Oncology. ,"Our study shows ...
... University of Georgia have suggested that cross-immunity created in ... protect against infection //,by related serotypes thus leading to ... This finding would help understand the pattern of this ... about the mid 1980s, there's been a sequential replacement ...
... nicotine dependence can develop in some smokers right after ... Smoking cessation programs for teenagers have had little ... the cessation programs aimed at youngsters for the programs ... use has traditionally been thought to progress through 5 ...
... listed on food labels to help cut heart disease, according ... experts putting forward their arguments in this week's British Medical ... combat the UK's number one killer, estimated to be responsible ... ,In addition cardiovascular disease is reported to cost the ...
... medically shocking incident, a 35-year-old woman in Madhya Pradesh survived ... was however operated upon Friday at the government hospital at ... a kilo-and-half was finally removed from her womb. ... menstrual cycle started in the seventh month of her pregnancy, ...
Cached Medicine News:Health News:Second Alagille Syndrome Gene discovered: More information on kidney disease 2Health News:CHEK 2 Gene Mutation Triples Breast Cancer Risk 2Health News:Waxing And Waning Of Dengue Epidemics Attributed To Cross-Immunity 2Health News:Waxing And Waning Of Dengue Epidemics Attributed To Cross-Immunity 3Health News:Scientists Push for Labeling of all Fats to Avoid Heart Disease 2
(Date:8/21/2014)... Inc. (NASDAQ: CYBX ) today announced results for ... highlights 1   Operating results for the first ... fiscal 2014, and other achievements, include: , Worldwide net ... , Strong international net sales of $13.2 million, an increase ... net product sales reached a new high of $58.8 million, ...
(Date:8/21/2014)... 2014 Asterias Biotherapeutics, Inc. (OTCBB: ASTY), a ... medicine, announced today the appointments of Andrew ("Andy") Arno ... Board of Directors. With these additions, the Asterias Board ... are independent. Andy Arno , 55, ... companies. He is currently Managing Director of Emerging Growth ...
(Date:8/20/2014)... HOLBROOK, N.Y. , Aug. 20, 2014 /PRNewswire/ ... MDIN) today announced that after months of hard ... finally finished the new Snorenz formulation and package ... vitamins E and B-6 back into the product ... well as longer lasting effects.  Snorenz Nighttime will ...
Breaking Medicine Technology:Cyberonics Reports Fiscal 2015 First Quarter Results 2Cyberonics Reports Fiscal 2015 First Quarter Results 3Cyberonics Reports Fiscal 2015 First Quarter Results 4Cyberonics Reports Fiscal 2015 First Quarter Results 5Cyberonics Reports Fiscal 2015 First Quarter Results 6Cyberonics Reports Fiscal 2015 First Quarter Results 7Cyberonics Reports Fiscal 2015 First Quarter Results 8Cyberonics Reports Fiscal 2015 First Quarter Results 9Cyberonics Reports Fiscal 2015 First Quarter Results 10Cyberonics Reports Fiscal 2015 First Quarter Results 11Cyberonics Reports Fiscal 2015 First Quarter Results 12Cyberonics Reports Fiscal 2015 First Quarter Results 13Cyberonics Reports Fiscal 2015 First Quarter Results 14Cyberonics Reports Fiscal 2015 First Quarter Results 15Cyberonics Reports Fiscal 2015 First Quarter Results 16Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 2Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 3Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 4Northstar completes the first phase of its new retail strategy and prepares to ship reformulated Snorenz with all new packaging 2
... W.Va., June 19 Keeping your teeth brushed and flossed can ... and stroke, dentists have warned for years. Now researchers at ... help preserve memory. , , The National Institutes of Health ... further build on studies linking gum disease and mild to moderate ...
... Florida,s First Three-Year Neuroscience Research Doctorate Program , ... Roskamp Institute (Roskamp) today announced the first enrollment ... through which students will conduct full-time laboratory research ... is an Affiliated Research Centre (ARC) of the ...
Cached Medicine Technology:School of Dentistry Studies Link Between Oral Health and Memory 2Roskamp Institute Announces Enrollment of First Students to Participate in its Innovative Research Doctorate Program 2Roskamp Institute Announces Enrollment of First Students to Participate in its Innovative Research Doctorate Program 3
... Speed Pre and Post High Vacuum Autoclaves. ... designed to cover a large of applications ... well as private clinics and dental offices. ... of medical and surgical materials such as ...
... manual autoclaves set the standard for steam ... to compliment any healthcare and laboratory facility. ... of your sterilization needs. Time tested reliability ... product. The Tuttnauer M Series is also ...
... is a confocal laser scanning microscope ... images of the posterior segment. It ... retinal topography and precise follow-up of ... routine application of Heidelberg Retina Tomograph ...
Subjective refraction unit, computer controlled and programmable. Two versions: with and without prisms....
Medicine Products: