Navigation Links
Bevacizumab (Avastin) fails to improve survival for newly diagnosed glioblastoma patients
Date:2/19/2014

BALTIMORE February 19, 2014. Adding bevacizumab (Avastin) to standard chemotherapy and radiation treatment does not improve survival for patients newly diagnosed with the often deadly brain cancer glioblastoma, researchers report in the Feb. 20 issue of the New England Journal of Medicine.

"We didn't see an improvement in overall survival or a statistically significant increase in progression-free survival, as defined in the context of this trial," says the study's senior author, Minesh P. Mehta, M.B., Ch.B., Professor of Radiation Oncology at the University of Maryland School of Medicine and a radiation oncologist at the University of Maryland Marlene and Stewart Greenebaum Cancer Center.

The U.S. Food and Drug Administration (FDA) has approved the use of bevacizumab to treat recurrent glioblastoma. Researchers sought to learn whether the drug could be beneficial as a first-line treatment.

The Phase III clinical trial, conducted by the Radiation Therapy Oncology Group (RTOG), randomized 637 patients at multiple centers, including the University of Maryland Greenebaum Cancer Center, into two groups.

Patients who received the standard treatment, plus a placebo, had a median survival of 16.1 months compared to 15.7 months for those who received the standard treatment plus bevacizumab. Although it took slightly longer for the cancer to progress in patients receiving bevacizumab (10.7 months vs. 7.3 months), the rate of progression-free survival did not meet pre-specified criteria to be statistically meaningful, according to Dr. Mehta.

Dr. Mehta, who chairs the RTOG's brain tumor committee, says researchers also found an increase in symptoms among patients who took bevacizumab, compared to a placebo. "We observed higher rates of neurocognitive decline, increased symptom burden and a decline in health-related quality of life over time among non-progressing patients treated with bevacizumab," he says. Bevacizumab'
'/>"/>

Contact: Karen Warmkessel
kwarmkessel@umm.edu
410-328-8919
University of Maryland Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Phase II trial of Bevacizumab (Avastin) in locally advanced cervical cancer promising
2. Researchers detail possible resistance mechanisms of colorectal cancer to bevacizumab (Avastin)
3. Brain cancer survival improved following FDA approval of bevacizumab, Mayo study finds
4. Test helps target glioblastoma patients most likely to benefit from bevacizumab
5. Bevacizumab offers no benefit for newly diagnosed glioblastoma, M.D. Anderson-led study finds
6. Study finds glioblastoma patients treated with bevacizumab experience reduced cognitive function and quality of life
7. Time to tumor growth helps predict survival benefit of Bevacizumab for patients with metastatic colorectal cancer
8. In-Depth Health Claim Review Saves Client Up to $15,000 on Surgery that Fails to Meet Standards for Medical Necessity
9. Mayo-led study: Drug fails to reduce diarrhea in patients receiving radiation therapy
10. Study Says Using the da Vinci Surgical Robot for a Hysterectomy Fails to Cut Complications and May Raise Pneumonia Risk, Notes Parker Waichman LLP
11. Cosmetic surgery to look whiter fails to boost womens self-esteem
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... , ... August 29, 2015 , ... ... insufficient scrotal support and protection against dribbled urine and sweat. "In order to ... Hills, N.Y. , The EASY ACCESS DRYNESS ENHANCED MEN'S UNDERGARMENT provides optimal support ...
(Date:8/29/2015)... ... August 29, 2015 , ... ProDrop Particles includes over 40 particle backdrops designed ... of unique footage that users can shrink and stretch in the Final Cut Pro ... can customize color, brightness, scale, speed, range, and flare attributes with intuitive controls found ...
(Date:8/28/2015)... , ... August 29, 2015 , ... Rio Salado ... learning and the student experience as part of the EDUCAUSE - Next Generation Learning ... . , This is the third Breakthrough Models Incubator hosted by EDUCAUSE ...
(Date:8/28/2015)... CA (PRWEB) , ... August 28, 2015 , ... An ... journey that local pizza maker Paul LaRocco has gone through to open a pizzeria ... approval and permitting process tends to take several months, but the current process, having ...
(Date:8/28/2015)... ... August 28, 2015 , ... The 6th Annual Survivor ... Aneurysm Foundation has added yet another accolade to its cadre of widespread support—an official ... , “With the help of the medical community and the University of Illinois at ...
Breaking Medicine News(10 mins):Health News:Modified Men’s Underwear Promote More Comfort and Hygiene - Designed by InventHelp Client (LGI-1968) 2Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 3Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 4Health News:Article on Building Approval Process for LA Business Highlights the Need for a Bridge Between Businesses and City Officials, says Fire Protection Group Inc. 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 3
... the world will gather for Digestive Disease Week 2010 ... May 1 to May 5, 2010, at the Ernest ... the annual meeting of the American Gastroenterological Association (AGA) ... world. AGA researchers will present exciting, cutting-edge data during ...
... symptoms, could help speed diagnosis, findings show , FRIDAY, ... technique can identify changes in speech associated with the ... found. , "This is a noninvasive, reliable and accurate ... a few simple sentences," Shimon Sapir, of the department ...
... ... to child health advocacy , ... Vancouver, BC (Vocus) April 30, 2010 -- Pediatric experts from Children,s National ... 2010 Pediatric Academic Societies Annual Meeting—one of the largest annual meetings of health experts focused ...
... ... 18th during Hearing Aid Roundup , ... Braunfels, TX (Vocus) April 30, 2010 -- Estes Audiology and the Windcrest SERTOMA ... down to the Hearing Aid Roundup at Estes Audiology in New Braunfels on Tuesday, May 18, ...
... fares worse than many other countries, CDC experts say , ... latest year for which figures are available, about seven infants ... 3 percent drop from 2005 and the lowest infant death ... the drop in infant mortality was significant, the United States ...
... washes , FRIDAY, April 30 (HealthDay News) -- Rinsing the ... way to try to reduce allergy symptoms and sinus infections ... simple treatment might also help prevent ear infections in young ... received an average of four nasal irrigations four days a ...
Cached Medicine News:Health News:AGA presents cutting-edge research during DDW 2Health News:AGA presents cutting-edge research during DDW 3Health News:AGA presents cutting-edge research during DDW 4Health News:Voice Analysis May Allow Early Detection of Parkinson's 2Health News:Experts from Children's National Medical Center to present at Pediatric Academic Societies' Annual Meeting 2Health News:Experts from Children's National Medical Center to present at Pediatric Academic Societies' Annual Meeting 3Health News:Estes Audiology and SERTOMA Club Windcrest Celebrate Better Hearing and Speech Month with Hearing Aid Roundup 2Health News:Estes Audiology and SERTOMA Club Windcrest Celebrate Better Hearing and Speech Month with Hearing Aid Roundup 3Health News:U.S. Infant Deaths on the Decline 2Health News:U.S. Infant Deaths on the Decline 3Health News:Nasal Saline Rinses Reduce Ear Infections in Kids 2Health News:Nasal Saline Rinses Reduce Ear Infections in Kids 3
(Date:8/28/2015)... , Aug. 28, 2015 Patterson Medical, ... (Nasdaq: PDCO ), is now an independent ... acquisition of Patterson Medical by Madison Dearborn Partners ... its name for a transition period before rebranding ... and sports medicine products.  With the focused resources ...
(Date:8/28/2015)... , Aug. 28, 2015 ... announced the addition of the "Investigation Report ... their offering. Developed by Pharmacia & ... receptor agonist which effectively reduces intraocular pressure. As ... latanoprost (under the trade name of Xalatan) entered ...
(Date:8/28/2015)... 28, 2015  IP Shakti, LLC, today announced that it ... Logo - http://photos.prnewswire.com/prnh/20150827/261551LOGO ... new corporate identity signifies our transformation into a company focused ... platform for patent claim validity." ... proprietary AIA Shield™ platform, the Company commenced a corporate re-branding ...
Breaking Medicine Technology:Patterson Medical Positioned for Continued Growth as a Newly Independent Company 2Patterson Medical Positioned for Continued Growth as a Newly Independent Company 3China Latanoprost Market Investigation Report 2015-2019 2IP Shakti, LLC Changes Company Name to Prediqtus, LLC 2
... Diversifies Revenue Streams and Boosts Scale in Existing Generics ... Expected to be Immediately Accretive to Adjusted Diluted Earnings per ... Company Reiterates Full-Year 2010 Financial Guidance ... today that it has entered into a definitive agreement to ...
... (Nasdaq: DCTH ) announced today that management will ... Tuesday, October 5, 2010 at 8:45 a.m. ET in New ... an overview of the Company,s business strategy and recent corporate ... only. Delcath will offer a live audio webcast of its ...
Cached Medicine Technology:Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 2Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 3Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 4Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 5Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 6Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 7Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 8Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 9Delcath to Present at the William Blair Emerging Growth Stock Conference 2
... for Western Blot analysis ... Western Blot Analyzer for many applications including ... presence of infectious diseases such as viruses ... accurate screening of allergies and other application ...
... Pens-Using a proprietary and patented technology, ADI ... called Antigen-Antibody pens-TM, that will allow researchers ... in any form or shape or size. ... to see antigen being written on the ...
... Store 200 to 350 Liters of ... Storage and Distribution of Purified Water,Millipores compact ... to store 200 to 350 liters of ... systems, and to maintain consistent purity of ...
... Liters of pure water, Complete, Compact Systems ... Water,Millipores compact S.D.S. Storage and Distribution Systems ... liters of purified water produced by Elix ... purity of stored water, provide effective protection ...
Medicine Products: