Navigation Links
Better protein capture a boon for drug manufacturers
Date:1/22/2014

Rice University scientists have created a way to fine tune a process critical to the pharmaceutical industry that could save a lot of time and money.

A combination of the Rice technique that provides pinpoint locations for single proteins and a theory that describes those proteins' interactions with other molecules could widen a bottleneck in the manufacture of drugs by making the process of isolating proteins five times more efficient.

The work by Rice chemist Christy Landes and her team will be reported online this week in the Proceedings of the National Academy of Sciences.

A critical step in drug manufacture is the separation of "proteins of interest" the active elements in drugs from other materials. The primary method used is ion-exchange chromatography, which is like using a colander to separate cooked pasta from water. In this case, a separation column removes proteins from water and other cellular material. Landes said raw material containing the proteins is injected into the top of a separation column, or tube. The mixture is the "mobile phase" of the process, and it can either be pulled through the tube via gravity or pushed through.

Along the way, the liquid encounters a "stationary phase," a structure that incorporates ligands binding ions or molecules. In theory, they capture only the proteins of interest, while the unwanted material passes through. The proteins are later washed off in a purifying step called elution. It's this stationary phase that Landes said should be tuned. That can only happen by knowing what occurs at the molecular level.

"Our fundamental understanding of this process at the level where proteins bind to ligands, which basically drives several different industries, is ridiculously small," she said. "We should take care to understand everything about separation, because up to half the cost of bringing a drug to market is for separation and purification and the global
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Three Reasons Why Eye Contact Creates Better Sex
2. “Ways To Become A Better Husband,” A New Article On Vkool.Com, Share Tips With Men On How To Be A Good Husband Easily - V-kool
3. New Per Wickstrom Blog Post Focuses On Five Ways to Become a Better Boss
4. “MMA For Beginners,” A New Article On Vkool.Com, Shares Tips With Readers On How To Be A Better MMA Fighter - V-kool
5. New Year’s Resolutions For A Better Sex Life
6. Sound Relief Hearing Center Announces the Winner of Their Second Annual "Gift of Better Hearing" Contest
7. How Eyelid Surgery Can Help You Look Better for the New Year at Gallery of Cosmetic Surgery
8. Celebrate a New Year With Better Health; Take 10% Off All Water and Air Purification Systems to Benefit the Health of Your Loved Ones
9. Sleep Tracker Review
10. How This Program Helps People Sleep Better Naturally – HealthReviewCenter
11. “20 Longer Living Tips,” A New Article On The Site Vkool.Com, Teaches People How To Live Longer And Better - V-kool
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... New York, New York (PRWEB) September 17, 2014 ... ) filings involving the Conserve line of metal-on-metal ... litigation now underway in U.S. District Court, Northern ... to an updated Case List issued by the ... 15, 2014, at least 397 product liability claims ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 The Food ... today, September 17, 2014, to consider: , ... Therapy (TRT), and, 2. The potential ... , With the TRT litigation ongoing, an informally-organized litigation ... the dangers of testosterone replacement therapy. Among others, ZKB ...
(Date:9/17/2014)... StartX , a nonprofit technology accelerator ... of funding at its Summer Demo Day yesterday. The ... was the first such gathering held at StartX’s new, ... The presentations were delivered on an expansive stage built ... 2,000 square foot life science facility that opened last ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 Cadiz ... treatments and cosmetic procedures to clients throughout Central ... of services is Collagen Induction Therapy. Using the ... are able to help clients correct a wide ... introduced this month, and Cadiz Laser Spa is ...
(Date:9/17/2014)... -- Present-day Europeans are the descendants of at ... a new study. Previous research suggested ... European farmers. But, a new genetic analysis involving ... descendants of Ancient North Eurasians. Nearly all present-day ... group, researchers from Harvard Medical School said. , ...
Breaking Medicine News(10 mins):Health News:Wright Hip Lawsuit News: Nearly 400 Filings Reported in Federal Wright Conserve Hip Replacement Litigation, Bernstein Liebhard LLP Reports 2Health News:Wright Hip Lawsuit News: Nearly 400 Filings Reported in Federal Wright Conserve Hip Replacement Litigation, Bernstein Liebhard LLP Reports 3Health News:FDA Advisory Committee Holds Hearing on Testosterone Safety 2Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 2Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 3Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 4Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 5Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 6Health News:Revolutionary Collagen Induction Therapy is Now Available at Cadiz Laser Spa 2Health News:Europeans Are Descendants of at Least 3 Ancient Human Groups: Study 2Health News:Europeans Are Descendants of at Least 3 Ancient Human Groups: Study 3
... no health insurance don,t see a doctor all year ... children share at least one frightening fact: If they are ... health care... period. , New research from the University ... children in families earning between $38,000 and $77,000 annually who ...
... Universitys Slone Epidemiology Center have found that approximately one ... and cold medications during a given week. These ... Academic Societies & Asian Society for Pediatric Research Joint ... medications are widely marketed in the U.S. but surprisingly ...
... Two new studies conducted by researchers at Cincinnati Childrens ... parental job loss on childrens healthcare and the importance ... healthcare needs and reduce healthcare disparities. , The studies ... meeting of the Pediatric Academic Societies in Honolulu. , ...
... Calif., May 2 The following is,being issued ... protect,Kaiser facilities will launch an unfair labor practice ... Tuesday, May 6. This is the,first-ever group of ... and spied on workers who were trying to ...
... JUROR MISCONDUCT, LITTLE ROCK, Ark., May 2 ... suing Arkansas Children,s Hospital,over a wrong sided brain surgery ... "We have concerns about the accuracy of statements made ... has been a possibility of,juror misconduct," said attorney Phillip ...
... immunotherapy technique to help prevent the progression from ... simple, cost-effective technique are published May 2nd in ... an overwhelming need for effective immunotherapies for HIV, ... highly toxic. The authors, led by Professor ...
Cached Medicine News:Health News:Middle Class Uninsured Kids' Health Risk Almost as High as Poor Children's 2Health News:1 in 10 children using cough, cold medications 2Health News:US unemployment having impact on kids' health-care coverage -- and that puts their health at risk 2Health News:First-Ever Group of Hospital Security Officers to Strike over Unfair Labor Practices, Walk out of Facilities Across California on May 6 2Health News:Wrong-Sided Brain Surgery Trial Halted 2
(Date:9/17/2014)... Sept. 17, 2014 /PRNewswire-iReach/ -- ChemImage announced ... discussing improvements in the development of imaging ... both normal and diseased tissue that minimizes ... surgical procedures, lowers surgical costs and potentially ... The clinical and scientific ...
(Date:9/17/2014)... Minn. , Sept. 17, 2014 ACIST ... global market leader of advanced imaging modalities for cardiology, ... System in two live cases at the Transcatheter Cardiovascular ... The cases were presented from Medstar Washington Hospital Center ... Hospital/Columbia University Medical Center ( New York, NY ...
(Date:9/17/2014)... 17, 2014  Millions of people suffer from neck and ... Recently the FDA approved the launch of a ... implant device developed by Spinal Kinetics, which may offer relief ... or arm pain. Hospital for Special Surgery (HSS), the number ... in New York City and in ...
Breaking Medicine Technology:Patient Outcomes Improve When Molecular Chemical Imaging Technology Is Used to Aid Robotic Surgical Procedures, According to New White Paper 2ACIST Launches HDi High-Definition IVUS 2ACIST Launches HDi High-Definition IVUS 3Cervical Disc Clinical Trial for People with Neck and Arm Pain Set to Begin at Hospital for Special Surgery 2
... Fenwal, Inc., a global medical technology company focused on ... names of 16 inspiring individuals inducted into the company,s 2010 ... than a decade, Fenwal has partnered with blood centers to ... in assuring medicine,s most vital natural resource -- blood -- ...
... Systems (NYSE: VAR ) today announced the execution ... to supply medical imaging subcomponents to Toshiba Medical Systems for ... will be booked over the period of the agreement. ... it marks the latest chapter in our 30+ year relationship ...
Cached Medicine Technology:2010 Inductees to the Fenwal Blood Donation Hall of Fame 22010 Inductees to the Fenwal Blood Donation Hall of Fame 3Varian Medical Systems Announces X-Ray Products Contract With Toshiba Medical Systems 2
ENDOlap™ laparoscopes provide excellent image linearity and flatness of field....
Inquire...
The Fujinon's R410 laparoscope is the first to bring a 410,000 pixel CCD to the end of the scope. Superior imaging and color replication, along with a unique lens washing capability make the R410 the...
ACMI™ Distortion-Free Laparoscopes utilize technical advances in optical lens design to provide images without the fish-eye effect typically found on the peripheral viewing edges of conventional...
Medicine Products: